DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdhb and PDHB

DIOPT Version :9

Sequence 1:	NP_651668.1	Gene:	Pdhb / 43437	FlyBaseID:	FBgn0039635	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_000916.2	Gene:	PDHB / 5162	HGNCID:	8808	Length:	359	Species:	Homo sapiens

Alignment Length:	353	Identity:	237/353 - (67%)
Similarity:	285/353 - (80%)	Gaps:	2/353 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRTRLIQAASSAQRAFSTSQKALAAKQMTVRDALNSALDDELARDDRVFILGEEVAQYDGAYKV 65
            ::|..|.:.:...:|.|..:  |.||.|:|||||:|..:|:||.||::||:||||||||||||||
Human     7 LVRRPLREVSGLLKRRFHWT--APAALQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKV 69

  Fly    66 SRGLWKKYGDKRVIDTPITEMGFAGIAVGAAMAGLRPVCEFMTWNFSMQAIDHIINSAAKTFYMS 130
            ||||||||||||:|||||:||||||||||||||||||:|||||:||||||||.:|||||||:|||
Human    70 SRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMS 134

  Fly   131 AGAVNVPIVFRGPNGAASGVAAQHSQCFAAWYAHCPGLKVLSPYDAEDARGLLKSAIRDPDPVVF 195
            .|...|||||||||||::||||||||||||||.|||||||:||:::|||:||:||||||.:|||.
Human   135 GGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVV 199

  Fly   196 LENELVYGTAFPVADNVADKDFLVPIGKAKVMRPGKDITLVAHSKAVETSLLAAAELAKKGIEAE 260
            |||||:||..|........||||:||||||:.|.|..||:|:||:.|...|.|||.|:|:|:|.|
Human   200 LENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECE 264

  Fly   261 VINLRSIRPLDTATIFASVRKTHHLVTVENGWPQHGVGAEICARIMEDQTFFELDAPVWRCAGVD 325
            |||:|:|||:|..||.|||.||:||||||.||||.||||||||||||...|..||||..|..|.|
Human   265 VINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGAD 329

  Fly   326 VPMPYAKTLEAHALPRVQDLVEATLKVL 353
            |||||||.||.:::|:|:|::.|..|.|
Human   330 VPMPYAKILEDNSIPQVKDIIFAIKKTL 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdhb	NP_651668.1	PLN02683	2..352	CDD:215368	235/349 (67%)
		TPP_PYR_E1-PDHc-beta_like	33..199	CDD:132919	133/165 (81%)
		Transketolase_C	222..340	CDD:280875	75/117 (64%)
PDHB	NP_000916.2	PRK11892	<32..355	CDD:237011	228/322 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148154
Domainoid	1	1.000	300	1.000	Domainoid score	I1419
eggNOG	1	0.900	-	-		E1_COG0022
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H712
Inparanoid	1	1.050	476	1.000	Inparanoid score	I1495
Isobase	1	0.950	-	0	Normalized mean entropy	S229
OMA	1	1.010	-	-		QHG53958
OrthoDB	1	1.010	-	-		D314250at33208
OrthoFinder	1	1.000	-	-		FOG0002922
OrthoInspector	1	1.000	-	-		oto88852
orthoMCL	1	0.900	-	-		OOG6_101309
Panther	1	1.100	-	-	LDO	PTHR11624
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R864
SonicParanoid	1	1.000	-	-		X2740
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750