DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ib and MNS1

DIOPT Version :9

Sequence 1:	NP_651667.1	Gene:	alpha-Man-Ib / 43436	FlyBaseID:	FBgn0039634	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_175570.1	Gene:	MNS1 / 841584	AraportID:	AT1G51590	Length:	560	Species:	Arabidopsis thaliana

Alignment Length:	509	Identity:	219/509 - (43%)
Similarity:	309/509 - (60%)	Gaps:	49/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 EPLSEGEQLEQAIKNPLTLGGVSFKEHLKKIK-----PILAKGQHFHGATNERQSAVVAAFKHSW 247
            |.:|..||:.:.:.     |||..|. ||.:|     |:          ..:|:..|..|..|:|
plant    61 EEVSRLEQMLEELN-----GGVGNKP-LKTLKDAPEDPV----------DKQRRQKVKEAMIHAW 109

  Fly   248 AGYKKYAWGHDNLKPISQYSHEWF-GLGLTIVDSLDTMYIMGLDDEFKEGRDWVEQSLRFDTKRD 311
            :.|:|||||.|.|:|.::...:.| |||.|:||||||:||||||::|::.|:||..||.||...|
plant   110 SSYEKYAWGKDELQPRTKDGTDSFGGLGATMVDSLDTLYIMGLDEQFQKAREWVASSLDFDKDYD 174

  Fly   312 VNLFEVTIRVLGGLLSAYHLSGDTMFLAKAAELGNRLLPAFQSPSNIPYSDVNLGDLSAHSPKWS 376
            .::||.||||:|||||||.||||.|||.||.::.:|||||:.:|:.|||:.:||.:.:||:|.|:
plant   175 ASMFETTIRVVGGLLSAYDLSGDKMFLEKAKDIADRLLPAWNTPTGIPYNIINLRNGNAHNPSWA 239

  Fly   377 P--DSSTSEVTTIQLEFRDLSRSTNISIYEQVAHKVNEKVHDLEKN---HGLVPIFINANTGTFR 436
            .  ||..::..|.||||..||:.|....|:|   ||.:.:.:|.||   .||:||:||.:... .
plant   240 AGGDSILADSGTEQLEFIALSQRTGDPKYQQ---KVEKVITELNKNFPADGLLPIYINPDNAN-P 300

  Fly   437 NYATISLGARGDSYYEYLLKQWIQTGRKDNDNLILD-YMQAVDGVLTQLMRRTPREHWVYIGELI 500
            :|:|.:.||.|||:||||||.|:|..:........| :.:::.|:|:.:.:.|| ..:.||.|.
plant   301 SYSTTTFGAMGDSFYEYLLKVWVQGNKTSAVKPYRDMWEKSMKGLLSLVKKSTP-SSFTYICEK- 363

  Fly   501 NGKDFKPKMDHLTCYLPGTLILGHQNGMPDSH---LILARDLLDTCYQTYMMNPTHLAAEISYFA 562
            ||.:...|||.|.|:.||.|.||.....||..   |.||.:|..|||..|...||.||.|..:|.
plant   364 NGNNLIDKMDELACFAPGMLALGASGYGPDEEKKFLSLAGELAWTCYNFYQSTPTKLAGENYFFT 428

  Fly   563 LTEKDDQDIYVKPNDAHNLLRPEFVESLYYFYSITGNRTYQDMGWKIFQAFETHAKVNAGYTSMG 627
            .    .||:.|  ..:.|:||||.||||:|.:.:|||:|||:.||.||||||.:::|.:||..:.
plant   429 A----GQDMSV--GTSWNILRPETVESLFYLWRLTGNKTYQEWGWNIFQAFEKNSRVESGYVGLK 487

  Fly   628 NVKNTQSTRLRD-LMESFWMSETLKYFYLLFSDDRKEIDLEQWVFNSEGHPLPV 680
            :|    :|..:| .|:||:::|||||.|||||.. ..|.|::||||:|.|||.:
plant   488 DV----NTGAKDNKMQSFFLAETLKYLYLLFSPS-SVISLDEWVFNTEAHPLKI 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ib	NP_651667.1	Glyco_hydro_47	242..680	CDD:279825	205/448 (46%)
MNS1	NP_175570.1	Glyco_hydro_47	104..536	CDD:396217	205/448 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D693882at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830