Protein Alignment alpha-Man-Ib and MAN1C1

DIOPT Version :10

• Sequence 1: NP_651667.1
• Gene: alpha-Man-Ib / 43436
• FlyBaseID: FBgn0039634
• Length: 685
• Species: Drosophila melanogaster
• Sequence 2: NP_001372111.1
• Gene: MAN1C1 / 57134
• HGNCID: 19080
• Length: 664
• Species: Homo sapiens
• Alignment Length: 732
• Identity: 203/732 - (27%)
• Similarity: 330/732 - (45%)
• Gaps: 177/732 - (24%)

  Fly    31 WN-QLPRCQRNLIILGITGFCVTVLLCLSGDQLLAASLK-------------DVDTKAEVAAY-- 79
            |. :||  |:.|.:|.::|.   |.||.....||..|.:             .::..||:|.:
Human    15 WGLRLP--QKFLFLLFLSGL---VTLCFGALFLLPHSSRLKRLFLAPRTQQPGLEVVAEIAGHAP 74

  Fly    80 ---QMPLPNP-HHHPGVDKDVPKDTAAVPVPADKR---------APRVEAVSDKFNELVAYGEAN 131
               |.|.||| ...|...:|.|...|:   |..::         .||.||.:.:.|.:.|....:
Human    75 AREQEPPPNPAPAAPAPGEDDPSSWAS---PRRRKGGLRRTRPTGPREEATAARGNSIPASRPGD 136

  Fly   132 SAENVARLPETVAAEGLPQASAMAVALPPPDSNKEQDIGGIDILNNVEEPV----AQDPAEPLSE 192
                          ||:|...         |.|.        ..:.:..||    |.:..||.|:
Human   137 --------------EGVPFRF---------DFNA--------FRSRLRHPVLGTRADESQEPQSQ 170

  Fly   193 GEQLEQAIKNPLTLGGVSFKEHLKKIKPILAKGQHFHGATNERQSAVVAAFKHSWAGYKKYAWGH 257
                              .:...:|||.::                     :.:|..||:||.|.
Human   171 ------------------VRAQREKIKEMM---------------------QFAWQSYKRYAMGK 196

  Fly   258 DNLKPISQ--YSHEWFGL------------------------------------GLTIVDSLDTM 284
            :.|:|:::  |....||.                                    |.|::|||||:
Human   197 NELRPLTKDGYEGNMFGANPSGEDRVAGKADPCVMPLVMKAGENQRRQGDRGLSGATVIDSLDTL 261

  Fly   285 YIMGLDDEFKEGRDWVEQSLRFDTKRDVNLFEVTIRVLGGLLSAYHLSGDTMFLAKAAELGNRLL 349
            |:|.|.:||:|.:.||.:|...:...:.:||||.||.:||||||::|:|:.:|..||..||.:||
Human   262 YLMELKEEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLL 326

  Fly   350 PAFQSPSNIPYSDVNLGDLSAHSPKW-----SPDSSTSEVTTIQLEFRDLSRSTNISIYEQVAHK 409
            |||.:|:.||     .|.:|..|..|     ...|..:|..::.|||..|:..:...::.:....
Human   327 PAFNTPTGIP-----KGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRN 386

  Fly   410 VNEKVHDLEKNHGLVPIFINANTGTFRNYATISLGARGDSYYEYLLKQWIQTGRKDND--NLILD 472
            :.:.:..:||..||.|.|::..:|.:..: .:|:|..|||:||||:|.|:.:|:.|.:  |:
Human   387 IRKVLRKIEKPFGLYPNFLSPVSGNWVQH-HVSVGGLGDSFYEYLIKSWLMSGKTDMEAKNM--- 447

  Fly   473 YMQAVDGVLTQLMRRTPREHWVYIGELINGKDFKPKMDHLTCYLPGTLILGHQNGMPDS---HLI 534
            |.:|::.:.|.|:..:| ....||.|. .|.....||.||.|:..|.:.||.::...:.   :..
Human   448 YYEALEAIETYLLNVSP-GGLTYIAEW-RGGILDHKMGHLACFSGGMIALGAEDAKEEKRAHYRE 510

  Fly   535 LARDLLDTCYQTYMMNPTHLAAEISYFALTEKDDQDIYVKPNDAHNLLRPEFVESLYYFYSITGN 599
            ||..:..||:::|..:.|.|..|..:|   ....:.:..:.::::.:||||.|||..|.:..|.|
Human   511 LAAQITKTCHESYARSDTKLGPEAFWF---NSGREAVATQLSESYYILRPEVVESYMYLWRQTHN 572

  Fly   600 RTYQDMGWKIFQAFETHAKVNAGYTSMGNVKNTQSTRLRD-LMESFWMSETLKYFYLLFSDDRKE 663
            ..|::.||::..|.|.:.:..||::.:.:|.:  ||...| ..:||:::|||||.|||||:| ..
Human   573 PIYREWGWEVVLALEKYCRTEAGFSGIQDVYS--STPNHDNKQQSFFLAETLKYLYLLFSED-DL 634

  Fly   664 IDLEQWVFNSEGHPLPV 680
            :.||.||||:|.|||||
Human   635 LSLEDWVFNTEAHPLPV 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ib	NP_651667.1	Glyco_hydro_47	242..680	CDD:460241	155/486 (32%)
MAN1C1	NP_001372111.1	Glyco_hydro_47	181..651	CDD:460241	155/507 (31%)