Protein Alignment alpha-Man-Ib and MAN1A1

DIOPT Version :10

• Sequence 1: NP_651667.1
• Gene: alpha-Man-Ib / 43436
• FlyBaseID: FBgn0039634
• Length: 685
• Species: Drosophila melanogaster
• Sequence 2: XP_005267043.1
• Gene: MAN1A1 / 4121
• HGNCID: 6821
• Length: 736
• Species: Homo sapiens
• Alignment Length: 675
• Identity: 224/675 - (33%)
• Similarity: 342/675 - (50%)
• Gaps: 74/675 - (10%)

  Fly    23 GRKSLRRAWNQLPRCQRNLIILGITGFCVTVLLCLSGDQLLAASLKDVDTKAEVAAYQMPL--PN 85
            |||....|  .|...::.:::|..:.|   :.||......|..|.|   ..:.|..:..|.  |.
Human   110 GRKGSGPA--ALRLTEKFVLLLVFSAF---ITLCFGAIFFLPDSSK---LLSGVLFHSSPALQPA 166

  Fly    86 PHHHPGVDKDVPKDTAAVPVPADKRAPRVE--AVSDKFNELVAYGEANSAENVARLPETVAAEGL 148
            ..|.||       ..|.....|:.||.|.|  |..|.        ||...:|:||:.|. ....|
Human   167 ADHKPG-------PGARAEDAAEGRARRREEGAPGDP--------EAALEDNLARIREN-HERAL 215

  Fly   149 PQASAMAVALPPPDSNKEQDIGGIDILNNVEEPVAQDPAEPLSEGEQLEQAIKNPLT-LGGVSFK 212
            .:|......||   ...::||    :|.  ::.||||         ||..  |.|.. |..|.|
Human   216 REAKETLQKLP---EEIQRDI----LLE--KKKVAQD---------QLRD--KAPFRGLPPVDF- 259

  Fly   213 EHLKKIKPI-LAKGQHFHGATNERQSAVVAAFKHSWAGYKKYAWGHDNLKPISQ--YSHEWFG-- 272
                 :.|| :...:....|..|:::.:....||:|..||.||||.:.|||||:  :|...||
Human   260 -----VPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNI 319

  Fly   273 LGLTIVDSLDTMYIMGLDDEFKEGRDWVEQSLRFDTKRDVNLFEVTIRVLGGLLSAYHLSGDTMF 337
            .|.||||:|||::||.:..||:|.:.|||::|.|:...::::|||.||.:|||||||:|||:.:|
Human   320 KGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEIF 384

  Fly   338 LAKAAELGNRLLPAFQSPSNIPYSDVNLGDLSAHSPKWSPDSST--SEVTTIQLEFRDLSRSTNI 400
            ..||.|||.:|||||.:||.||::.:|:......:..|:...|:  :|..|:.|||..||..:..
Human   385 RKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGN 449

  Fly   401 SIYEQVAHKVNEKVHDLEKNHGLVPIFINANTGTFRNYATISLGARGDSYYEYLLKQWIQTGRKD 465
            .|:.:....:...::.|||..||.|.::|.::|.:..: .:|:|..|||:||||||.|:.:.:.|
Human   450 PIFAEKVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQH-HVSVGGLGDSFYEYLLKAWLMSDKTD 513

  Fly   466 NDNLILDYMQAVDGVLTQLMRRTPREHWVYIGELINGKDFKPKMDHLTCYLPGTLILGHQ---NG 527
            .:...: |..||..:.|.|:|:: .....||.|...|. .:.||.||||:..|...||..   .|
Human   514 LEAKKM-YFDAVQAIETHLIRKS-SSGLTYIAEWKGGL-LEHKMGHLTCFAGGMFALGADAAPEG 575

  Fly   528 MPDSHLILARDLLDTCYQTYMMNPTHLAAEISYFALTEKDDQDIYVKPNDAHNLLRPEFVESLYY 592
            |...:|.|..::..||:::|......|..|...|   :...:.|..:.|:.:.:||||.:|:..|
Human   576 MAQHYLELGAEIARTCHESYNRTFMKLGPEAFRF---DGGVEAIATRQNEKYYILRPEVMETYMY 637

  Fly   593 FYSITGNRTYQDMGWKIFQAFETHAKVNAGYTSMGNVKNTQSTRLRDLMESFWMSETLKYFYLLF 657
            .:.:|.:..|:...|:..:|.|.|.:||.||:.:.:|.....: ..|:.:||:::|||||.||:|
Human   638 MWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHES-YDDVQQSFFLAETLKYLYLIF 701

  Fly   658 SDDRKEIDLEQWVFNSEGHPLPVYP 682
            ||| ..:.||.|:||||.|.||:.|
Human   702 SDD-DLLPLEHWIFNSEAHLLPILP 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ib	NP_651667.1	Glyco_hydro_47	242..680	CDD:460241	168/446 (38%)
MAN1A1	XP_005267043.1	Glyco_hydro_47	285..723	CDD:460241	168/446 (38%)