DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ib and Edem1

DIOPT Version :9

Sequence 1:	NP_651667.1	Gene:	alpha-Man-Ib / 43436	FlyBaseID:	FBgn0039634	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_001259152.1	Gene:	Edem1 / 31154	FlyBaseID:	FBgn0023511	Length:	1004	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	151/532 - (28%)
Similarity:	233/532 - (43%)	Gaps:	122/532 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 GVSFKEHLKKIKPILAKGQHFHGATNERQSAVVAAFKHSWAGYKKYAWGHDNLKPISQYSHE-WF 271
            |||.::...|.:.:            |.:..|...|:|::.||.::|..:|.|:|::...|: |.
  Fly    26 GVSGQKQYSKARKL------------ELREDVRRMFQHAYDGYLRHASNYDELRPLTCDGHDTWG 78

  Fly   272 GLGLTIVDSLDTMYIMGLDDEFKEGRDWVEQSLRFDTKRDVNLFEVTIRVLGGLLSAYHLS---- 332
            ...||::|:|||:..||...||:.....:|:.:.||...:|::||..||::||||||:.||
  Fly    79 SYSLTLIDALDTLATMGNFTEFRRAARLLEEKMDFDRDINVSVFETNIRIVGGLLSAHLLSKRAG 143

  Fly   333 ----------GDTMFLAKAAELGNRLLPAFQSPSNIPYSDVNL------GDLSAHSPKWSPDSST 381
                      |..:.||:  ::..||||||.:.:.:||..|||      |:.|.        :.|
  Fly   144 VELEPGWPCKGPLLRLAE--DVARRLLPAFVTNTGMPYGTVNLRYGVPKGETSI--------TCT 198

  Fly   382 SEVTTIQLEFRDLSRSTNISIYEQVAHKVNEKVHDLEKNHGLVPIF---INANTGTFRNYATISL 443
            :.|.|..:||..|||.|..:|||.||.|.   ||.|......:.:|   |:..:|.:....: .:
  Fly   199 AGVGTFLIEFGTLSRLTGKTIYEDVAMKA---VHALWAYRSPIGLFGNHIDVQSGRWTALDS-GI 259

  Fly   444 GARGDSYYEYLLKQWIQTGRKDNDNLILDYMQAVDGVLTQLMRRTPREHW-VYIGELINGKDFKP 507
            ||..||.:|||:|..:...|.:    :|:........:.:.||   :|.| |::| :..|:...|
  Fly   260 GAGVDSLFEYLVKASVLLNRPE----LLELFHEARAAIDKYMR---KEDWYVWVG-MNKGRVTLP 316

  Fly   508 KMDHLTCYLPGTL-ILGHQNGMPDSHLILARDLLDT------------CYQTYMMNPTHLAAEIS 559
            ....|..:.||.| |:|                 ||            .::.|...|     |..
  Fly   317 VFQSLEAFWPGILSIIG-----------------DTEPALRTISRYIGVWKKYGFLP-----EFY 359

  Fly   560 YFALTEKDDQDIYVKPNDAHNLLRPEFVESLYYFYSITGNRTYQDMGWKIFQAFETHAKVNAGYT 624
            ..|..|       ..||.....||||.:||..|.|..|||....:.|..:.:..|..||...||.
  Fly   360 NIAAGE-------ASPNREVYPLRPELIESAMYLYRATGNEYLLEFGEHMLETLEFSAKTKCGYA 417

  Fly   625 SMGNVKNTQSTRLRDLMESFWMSETLKYFYLLF------------------SDDRKEIDLEQWVF 671
            ::.||...:.   .:.||||:::||.||.||||                  .||...:....::|
  Fly   418 TIRNVVTHEK---ENRMESFFLAETSKYLYLLFDEENFLHNDGSGGELLSTEDDVCVVQAGAYIF 479

  Fly   672 NSEGHPLPVYPL 683
            |:|.||:.:..|
  Fly   480 NTEAHPMDMSAL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ib	NP_651667.1	Glyco_hydro_47	242..680	CDD:279825	144/493 (29%)
Edem1	NP_001259152.1	Glyco_hydro_47	48..486	CDD:279825	143/491 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840