Protein Alignment alpha-Man-Ib and Man1a2

DIOPT Version :10

• Sequence 1: NP_651667.1
• Gene: alpha-Man-Ib / 43436
• FlyBaseID: FBgn0039634
• Length: 685
• Species: Drosophila melanogaster
• Sequence 2: NP_034893.1
• Gene: Man1a2 / 17156
• MGIID: 104676
• Length: 641
• Species: Mus musculus
• Alignment Length: 590
• Identity: 190/590 - (32%)
• Similarity: 306/590 - (51%)
• Gaps: 80/590 - (13%)

  Fly   139 LPETVAAEGLPQASAMAVALPPPDSNKEQDIGGIDILNNV----EEPVAQDPAEPL--------- 190
            :|...|.:|........:..|....::|::    :.|.|.    .|...::..|.|
Mouse    75 IPHVDAGKGAKNPGVFLIHGPDEHRHREEE----ERLRNKIRADHEKALEEAKEKLRKSREEIRA 135

  Fly   191 ---SEGEQLEQAIKNPLT--------------LGG----VSFKEHLKKIKPILAKGQHFHGATNE 234
               :|..::.||:|...|              .||    :..|:...|||.::
Mouse   136 EIQTEKNKVAQAMKTKETRVLPPVPVPQRVGVSGGDPEDMEIKKKRDKIKEMM------------ 188

  Fly   235 RQSAVVAAFKHSWAGYKKYAWGHDNLKPISQYSHEW--FG---LGLTIVDSLDTMYIMGLDDEFK 294
                     ||:|..|:.|.|||:.|:||::..|..  ||   :|.||||:|||:|||||.|||.
Mouse   189 ---------KHAWDNYRTYGWGHNELRPIARKGHSTNIFGSSQMGATIVDALDTLYIMGLHDEFM 244

  Fly   295 EGRDWVEQSLRFDTKRDVNLFEVTIRVLGGLLSAYHLSGDTMFLAKAAELGNRLLPAFQSPSNIP 359
            :|:.|:|::|.|....:|::|||.||.:||||:||:|||:.:|..||.:|..:|||||.:|:.||
Mouse   245 DGQRWIEENLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKTKAVQLAEKLLPAFNTPTGIP 309

  Fly   360 YSDVNLGDLSAHSPKWSPDSST--SEVTTIQLEFRDLSRST-NISIYEQVAHKVNEKVHDLEKNH 421
            ::.|||......:..|:...|:  :|..|:.:||..||..| :::.|.:|.| :.:.:..:|:.:
Mouse   310 WAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFVHLSYLTGDLTYYNKVMH-IRKLLQKMERPN 373

  Fly   422 GLVPIFINANTGTFRNYATISLGARGDSYYEYLLKQWIQTGRKDNDNLILDYMQAVDGVLTQLMR 486
            ||.|.::|..||.:..|.| |:|..|||:||||||.|:.:.:.|::...: |..||:.:...|::
Mouse   374 GLYPNYLNPRTGRWGQYHT-SVGGLGDSFYEYLLKAWLMSDKTDHEARRM-YDDAVEAIEKHLIK 436

  Fly   487 RTPREHWVYIGELINGKDFKPKMDHLTCYLPGTLILGHQNGMPDS---HLILARDLLDTCYQTYM 548
            :: |...|:|||..|| ..:.||.||.|:..|...||......|.   :|.|..::..||:::|.
Mouse   437 KS-RGGLVFIGEWKNG-HLERKMGHLACFAGGMFALGADGSRKDKAGHYLELGAEIARTCHESYD 499

  Fly   549 MNPTHLAAEISYFALTEKDDQDIYVKPNDAHNLLRPEFVESLYYFYSITGNRTYQDMGWKIFQAF 613
            .....|..|...|   :...:.:.|:..:.:.:||||.:|:.:|.:..|.:..|:..||:...|.
Mouse   500 RTALKLGPESFKF---DGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAI 561

  Fly   614 ETHAKVNAGYTSMGNVKNTQSTRLRDLMESFWMSETLKYFYLLFSDDRKEIDLEQWVFNSEGHPL 678
            |...:|:.|::.:.:|....... .|:.:||:::|||||.|||||.| ..:.|:.||||:|.|||
Mouse   562 EKSCRVSGGFSGVKDVYAPTPVH-DDVQQSFFLAETLKYLYLLFSGD-DLLPLDHWVFNTEAHPL 624

  Fly   679 PVYPL 683
            ||..|
Mouse   625 PVLRL 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ib	NP_651667.1	Glyco_hydro_47	242..680	CDD:460241	166/448 (37%)
Man1a2	NP_034893.1	PTZ00121	<109..208	CDD:173412	24/119 (20%)
		Glyco_hydro_47	187..626	CDD:460241	166/469 (35%)