Protein Alignment alpha-Man-Ib and MAN1B1

DIOPT Version :9

• Sequence 1: NP_651667.1
• Gene: alpha-Man-Ib / 43436
• FlyBaseID: FBgn0039634
• Length: 685
• Species: Drosophila melanogaster
• Sequence 2: XP_024303171.1
• Gene: MAN1B1 / 11253
• HGNCID: 6823
• Length: 754
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 228/576 - (39%)
• Similarity: 322/576 - (55%)
• Gaps: 80/576 - (13%)

  Fly    24 RKSLRRAWNQLPRCQRNLI--ILGITGFCVTVLLCLSGDQLLAASLK---DVDTKAEVAAYQMPL 83
            |:|..|.|.||.|.|||:|  :|....||..:......|...|.:.:   :...:.|:|..:
Human    68 RRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQKMRPEIAGLK--- 129

  Fly    84 PNPHHHPGVDKDVPKDTAAVPVP--ADKRAPRVEAVSDKFNELVAYGEANSAENVARLPETVAAE 146
                         |.:...:|.|  ||.....:..:|.:          .:..::.|
Human   130 -------------PANPPVLPAPQKADTDPENLPEISSQ----------KTQRHIQR-------- 163

  Fly   147 GLPQASAMAVALPPPDSNKEQDIGGIDILNNVEEPVA---QDPAEPLSEGE-------------Q 195
            |.|.     :.:.||..         |:.:..:|...   :.|.:|..||:             :
Human   164 GPPH-----LQIRPPSQ---------DLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIE 214

  Fly   196 LEQAIKNPLTLGGVSFKEHLKKIKPILAKGQHFHGATNERQSAVVAAFKHSWAGYKKYAWGHDNL 260
            .||..:.|.....|..|..|   .|...:|...|  .|.||..|:..|.|:|.||:|:|||||.|
Human   215 PEQGTELPSRRAEVPTKPPL---PPARTQGTPVH--LNYRQKGVIDVFLHAWKGYRKFAWGHDEL 274

  Fly   261 KPISQYSHEWFGLGLTIVDSLDTMYIMGLDDEFKEGRDWVEQSLRFDTKRDVNLFEVTIRVLGGL 325
            ||:|:...||||||||::|:||||:|:||..||:|.|.||.:.|.|:...||||||.|||:||||
Human   275 KPVSRSFSEWFGLGLTLIDALDTMWILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGL 339

  Fly   326 LSAYHLSGDTMFLAKAAELGNRLLPAFQSPSNIPYSDVNLGDLSAHSPKWSPDSSTSEVTTIQLE 390
            |||||||||::||.||.:.||||:|||::||.|||||||:|...||.|:|:.||:.:|||:||||
Human   340 LSAYHLSGDSLFLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLE 404

  Fly   391 FRDLSRSTNISIYEQVAHKVNEKVHDLE-KNHGLVPIFINANTGTFRNYATISLGARGDSYYEYL 454
            ||:|||.|....:::...||.:.:|.|. |..||||:|||.::|.|.:....:||||.|||||||
Human   405 FRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYL 469

  Fly   455 LKQWIQTGRKDNDNLILDYMQAVDGVLTQLMRRTPREHWVYIGELINGKDFKPKMDHLTCYLPGT 519
            ||||||.|:::. .|:.||::|::||.|.|:|.:......::|||.:|: |..|||||.|:||||
Human   470 LKQWIQGGKQET-QLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGR-FSAKMDHLVCFLPGT 532

  Fly   520 LILGHQNGMPDSHLILARDLLDTCYQTYMMNPTHLAAEISYFAL-TEKDDQDIYVK 574
            |.||..:|:|.||:.||::|::||||......|.|:.||.:|.| .:...:|:.||
Human   533 LALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVK 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ib	NP_651667.1	Glyco_hydro_47	242..680	CDD:279825	180/335 (54%)
MAN1B1	XP_024303171.1	Glyco_hydro_47	256..>588	CDD:307602	178/333 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148113
Domainoid	1	1.000	495	1.000	Domainoid score	I361
eggNOG	1	0.900	-	-		E1_KOG2431
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5230
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1336
Isobase	1	0.950	-	0	Normalized mean entropy	S1238
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0002927
OrthoInspector	1	1.000	-	-		oto89249
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	LDO	PTHR11742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2293
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.720