Protein Alignment alpha-Man-Ib and MAN1A2

DIOPT Version :9

• Sequence 1: NP_651667.1
• Gene: alpha-Man-Ib / 43436
• FlyBaseID: FBgn0039634
• Length: 685
• Species: Drosophila melanogaster
• Sequence 2: NP_006690.1
• Gene: MAN1A2 / 10905
• HGNCID: 6822
• Length: 641
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 187/574 - (32%)
• Similarity: 310/574 - (54%)
• Gaps: 48/574 - (8%)

  Fly   139 LPETVAAEGLPQASAMAVALPPPDSNKEQDIGGIDILNNVEEPVAQDPAEPLSEG-EQLE----- 197
            :|...|.:|........:..|....::|::       ..:...:..|..:.|.|. |:|.
Human    75 IPHVDAGKGAKNPGVFLIHGPDEHRHREEE-------ERLRNKIRADHEKALEEAKEKLRKSREE 132

  Fly   198 -----QAIKNPLTLGGVSFKEHLKKIKPI-------LAKGQHFHGATNERQSAVVAAFKHSWAGY 250
                 |..||.: :..:..||: |.:.|:       :..|........|::..:....||:|..|
Human   133 IRAEIQTEKNKV-VQEMKIKEN-KPLPPVPIPNLVGIRGGDPEDNDIREKREKIKEMMKHAWDNY 195

  Fly   251 KKYAWGHDNLKPISQYSH--EWFG---LGLTIVDSLDTMYIMGLDDEFKEGRDWVEQSLRFDTKR 310
            :.|.|||:.|:||::..|  ..||   :|.||||:|||:|||||.|||.:|:.|:|.:|.|....
Human   196 RTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNS 260

  Fly   311 DVNLFEVTIRVLGGLLSAYHLSGDTMFLAKAAELGNRLLPAFQSPSNIPYSDVNLGDLSAHSPKW 375
            :|::|||.||.:||||:||:|||:.:|..||.:|..:|||||.:|:.||::.|||......:..|
Human   261 EVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGW 325

  Fly   376 SPDSST--SEVTTIQLEFRDLSRST-NISIYEQVAHKVNEKVHDLEKNHGLVPIFINANTGTFRN 437
            :...|:  :|..|:.:||..||..| :::.|::|.| :.:.:..:::.:||.|.::|..||.:..
Human   326 ASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKVMH-IRKLLQKMDRPNGLYPNYLNPRTGRWGQ 389

  Fly   438 YATISLGARGDSYYEYLLKQWIQTGRKDNDNLILDYMQAVDGVLTQLMRRTPREHWVYIGELING 502
            |.| |:|..|||:||||||.|:.:.:.|::...: |..|::.:...|:::: |....:|||..||
Human   390 YHT-SVGGLGDSFYEYLLKAWLMSDKTDHEARKM-YDDAIEAIEKHLIKKS-RGGLTFIGEWKNG 451

  Fly   503 KDFKPKMDHLTCYLPGTLILGHQNGMPDS---HLILARDLLDTCYQTYMMNPTHLAAEISYFALT 564
             ..:.||.||.|:..|...||......|.   :|.|..::..||:::|......|..|...|
Human   452 -HLEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPESFKF--- 512

  Fly   565 EKDDQDIYVKPNDAHNLLRPEFVESLYYFYSITGNRTYQDMGWKIFQAFETHAKVNAGYTSMGNV 629
            :...:.:.|:..:.:.:||||.:|:.:|.:..|.:..|:..||:...|.|.:.:||.|::.:.:|
Human   513 DGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDV 577

  Fly   630 KNTQSTRLRDLMESFWMSETLKYFYLLFSDDRKEIDLEQWVFNSEGHPLPVYPL 683
            .::..|. .|:.:||:::|||||.|||||.| ..:.|:.||||:|.|||||..|
Human   578 YSSTPTH-DDVQQSFFLAETLKYLYLLFSGD-DLLPLDHWVFNTEAHPLPVLHL 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ib	NP_651667.1	Glyco_hydro_47	242..680	CDD:279825	165/448 (37%)
MAN1A2	NP_006690.1	ATP-synt_B	116..194	CDD:304375	16/79 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..175		3/22 (14%)
		Glyco_hydro_47	187..626	CDD:279825	165/448 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R728
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860