DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG11873 and BICRA

DIOPT Version :9

Sequence 1:NP_001263051.1 Gene:CG11873 / 43435 FlyBaseID:FBgn0039633 Length:3003 Species:Drosophila melanogaster
Sequence 2:NP_001381301.1 Gene:BICRA / 29998 HGNCID:4332 Length:1560 Species:Homo sapiens


Alignment Length:1982 Identity:398/1982 - (20%)
Similarity:637/1982 - (32%) Gaps:630/1982 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   812 DDDD--------------EDYGMGLETGLASE---SEPAQAH-APATGSAAATTGSSGDIMISIP 858
            ||:|              .|:..|.|. |.|:   ..|.:|. |...|.......:||:.:...|
Human     2 DDEDGRCLLDVICDPQALNDFLHGSEK-LDSDDLLDNPGEAQSAFYEGPGLHVQEASGNHLNPEP 65

  Fly   859 NQNGSDGLPFTLTIPAPQ-----------PQSSTGSQAAGNESATEIPNILIKIDPSAEAAVPPF 912
            ||            |||.           ...:||....|:..|.:..:||              
Human    66 NQ------------PAPSVDLDFLEDDILGSPATGGGGGGSGGADQPCDIL-------------- 104

  Fly   913 GLSTPRLPTAEEIQKQAQQHLAQQAAAAAAAAKATTATPTINISLPSMTLQPQVAPAPVVTPTPA 977
                             ||.| |:|                ||:..::..:.::...|...||..
Human   105 -----------------QQSL-QEA----------------NITEQTLEAEAELDLGPFQLPTLQ 135

  Fly   978 PSSNQVSTTVVVKPRRKPAVRRNAKKPDVTSSASNMISSSSGTTTTISSSTSTILNNSQPTTVNT 1042
            |:......|                      .|....:.::|.......||..:.....||.:..
Human   136 PADGGAGPT----------------------GAGGAAAVAAGPQALFPGSTDLLGLQGPPTVLTH 178

  Fly  1043 ITLTTPTPVTSSSNSTLMLTHGTPTAVPSQIGNIQISQVHNHHPSALPVSSAVENKIQIMPILPP 1107
            ..|..|..|.:.:.|.      .|...|..:||:.:..:..               :|.:|...|
Human   179 QALVPPQDVVNKALSV------QPFLQPVGLGNVTLQPIPG---------------LQGLPNGSP 222

  Fly  1108 GATVMGGTPGTGGHAPTTQSTQLVFQPAAPSVAPTITSDSTGFKLSSDGRQMQLVAIPQATPPSP 1172
            |    |.|..|.|.||    .|:|.||......||                .||:|  :..|.|.
Human   223 G----GATAATLGLAP----IQVVGQPVMALNTPT----------------SQLLA--KQVPVSG 261

  Fly  1173 AASSAQPPVPTPTPALTAGGATILPPQLTGMPANVSVSVGSPASAAALVPQLTGSLTLTVSEQCE 1237
            ..:||..| ..|....:||    :.||..|:....::|       ||:...|.|:.....:....
Human   262 YLASAAGP-SEPVTLASAG----VSPQGAGLVIQKNLS-------AAVATTLNGNSVFGGAGAAS 314

  Fly  1238 RLILRHDPNNPQDHQSQLILQALLKGAL---PNVTIINEPTRVDPNKQTTPMLQPQQQVIQI-PQ 1298
            .      |......|...:...|....|   |||.:...||.:.|  :...:|.|  ::.|: |:
Human   315 A------PTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQP--KPAGVLPP--KLYQLTPK 369

  Fly  1299 PLT----------QPQQILQQQPKVSTAPK-----IEVKVANNRKLSGQVTHPASSMLGMT---- 1344
            |..          :| ..|.||||   ||:     ...|...|..|||   .||.::....    
Human   370 PFAPAGATLTIQGEP-GALPQQPK---APQNLTFMAAGKAGQNVVLSG---FPAPALQANVFKQP 427

  Fly  1345 -STTTTMSTMKPPANLPAKQNEVVSFPQLPLNSQVLIQQQPMISAQLQPQLQPVTVPVSLPTQPV 1408
             :|||..:..:||..|    ::.:|...|...|.::|..|.|:..|.| .|.|....|.||.|..
Human   428 PATTTGAAPPQPPGAL----SKPMSVHLLNQGSSIVIPAQHMLPGQNQ-FLLPGAPAVQLPQQLS 487

  Fly  1409 PIPSPAPAPQLANNGQQRYIALPPIDPTTQQLFCLNSVTNQITAMSAGQTAASIGPTERLLIAP- 1472
            .:|        ||.|.|...|..|  .|..||.....:|||..|     ...|:||    ::|| 
Human   488 ALP--------ANVGGQILAAAAP--HTGGQLIANPILTNQNLA-----GPLSLGP----VLAPH 533

  Fly  1473 AGINAQQL--AQCLQLGQLHFNDVNPLPAQQQQQQVATTSSSMTLSMPLRPQPPQQQIVHPIQPI 1535
            :|.::..:  |..:|:||         ||..|........|..|.|.|....|....::      
Human   534 SGAHSAHILSAAPIQVGQ---------PALFQMPVSLAAGSLPTQSQPAPAGPAATTVL------ 583

  Fly  1536 TNGLAITTTASSTLTTTTSTTSLTTVTKQVANVAPIIDQSKAKLEPAKAATSGAGGGAVVKKKPV 1600
             .|:.:..:|.:.|.|........|........||::....|...|...:|....|   :::...
Human   584 -QGVTLPPSAVAMLNTPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLG---LQQPQA 644

  Fly  1601 RKPKATPTNASELANLKNASVVKPMPKLDPLSQKPNNNPVQIVQPNVASGKQMIVVGSSSCTTTT 1665
            ::|...||               |.....|.:..|..:      |.:||..:.||:|.....|.|
Human   645 QQPPQAPT---------------PQAAAPPQATTPQPS------PGLASSPEKIVLGQPPSATPT 688

  Fly  1666 TTTMSASIQPFQTTSGTKLVGVTVPMQQQQPTGTAAILQQQQQQRTSFSLTATTVAT---PA--P 1725
            ......|:|.|            :|.::.|        |....:....|:.|:.:.:   ||  |
Human   689 AILTQDSLQMF------------LPQERSQ--------QPLSAEGPHLSVPASVIVSAPPPAQDP 733

  Fly  1726 MPSPTVASGVSQLQMQQLPSQQAQQQLQPQ-------------------------QQQQLHAPKQ 1765
            .|:..||.|..  ...|.|..||.....||                         ....|.:|..
Human   734 APATPVAKGAG--LGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHP 796

  Fly  1766 QQPQPNTVSRVQTIQLTPQMQQIFKQVQMQIQFLTIKLQNKSTFLPVSPEIDSATIAAYNKPMTD 1830
            .:|.....||.|::...|                     ::....|..|.         ..|.| 
Human   797 TRPPSRPPSRPQSVSRPP---------------------SEPPLHPCPPP---------QAPPT- 830

  Fly  1831 AEINLALQRLFAEQHRILASGKEVPTP-EGMLPTANGTGGFSLMPQPVQQQQQQQQQQLQSTVPE 1894
                  |..:|..|:::     .||.| ....|||.|.      |||..:.|.|.        ||
Human   831 ------LPGIFVIQNQL-----GVPPPASNPAPTAPGP------PQPPLRPQSQP--------PE 870

  Fly  1895 -PLKTIVPANVVQPNNHSSTPAGAATSGATTAANIQQNITQRIHIYPMQHQQQQQQQQQQQQQQP 1958
             ||.   ||..:.|::.||..|.::.:.:...|....:.                 |.|....|.
Human   871 GPLP---PAPHLPPSSTSSAVASSSETSSRLPAPTPSDF-----------------QLQFPPSQG 915

  Fly  1959 QHQQQQPQHQLQQTGAKPKQAQPKPPPQQEQQSQLQIKPKEPANRSKVTSQQLQQNPQPPNGTIN 2023
            .|:...|...|...   |:.|.|.|||.:..|......|..|..::     .|::..|.|:|.| 
Human   916 PHKSPTPPPTLHLV---PEPAAPPPPPPRTFQMVTTPFPALPQPKA-----LLERFHQVPSGII- 971

  Fly  2024 MLPQKVSMMPVVQQQQQQQPQQHQQQPMLNKSGPPPLIFASSTNMLSNSNSNNLHNSNSAMQVNN 2088
                                       :.||:|..|....:||::      ..|.:..:::.|:.
Human   972 ---------------------------LQNKAGGAPAAPQTSTSL------GPLTSPAASVLVSG 1003

  Fly  2089 MLPL-PPLQPQQQPQPQLQQPPTPILPPVAPTMAMGVAPGPMGNLVP--------SLPTI----- 2139
            ..|. .|..|...|.|             ||..|.|:.|     |:|        :|||:     
Human  1004 QAPSGTPTAPSHAPAP-------------APMAATGLPP-----LLPAENKAFASNLPTLNVAKA 1050

  Fly  2140 ----PSLP--LYMPSKMDEM---PTQKPKIARLSLFVRQLEVDQESCLKPDYVKPFRTKDEAVKR 2195
                |..|  |...||:..:   ||.:|  ::.:.|:..|...|.|.|.|||...|.:.::|:.|
Human  1051 ASSGPGKPSGLQYESKLSGLKKPPTLQP--SKEACFLEHLHKHQGSVLHPDYKTAFPSFEDALHR 1113

  Fly  2196 LIRYHCMHENDVELPSD---EDEEFESTALEFQDKFRQLNGKFQEILMQESTLPHRTSELLQMQQ 2257
            |:.|| :::..:..|||   .|||||:.:.:...:.:.:..|::.:|::||.....::|::.:.:
Human  1114 LLPYH-VYQGALPSPSDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDR 1177

  Fly  2258 LMIDDLKGEINEIRTAEKELEQQLKEEQTSEKSTAESDVLSEAKVKEEIKQEPIDKSAQPDGVVD 2322
            :.|.:.|..:    ..:|:|.::..:|..|...:....:.:.::........|:..||.      
Human  1178 MFIQEEKTTL----ALDKQLAKEKPDEYVSSSRSLGLPIAASSEGHRLPGHGPLSSSAP------ 1232

  Fly  2323 KFDLLKNSADVNKAFSKSQPQQTTTVKQEESNESGEPSV-----NGSVKSEGHDKESSKYIKKDY 2382
                        .|.::..|...|.:........|.|||     :.|:.|......::..:..|.
Human  1233 ------------GASTQPPPHLPTKLVIRHGGAGGSPSVTWARASSSLSSSSSSSSAASSLDADE 1285

  Fly  2383 D------------NFDIESELTTSFIMKKVENKAALAKSAENRYQERNMMDQQQQQQHIKAN--- 2432
            |            .::..|.:.   :..|::.:|.|:|...|     ..:|...|.....|.   
Human  1286 DGPMPSRNRPPIKTYEARSRIG---LKLKIKQEAGLSKVVHN-----TALDPVHQPPPPPATLKV 1342

  Fly  2433 -----GGDPVDQDDGWYCLQKELNLMNNDHMQQSQQQLNGNQQHLP---INRQP---------AP 2480
                 ...|.....|                     |:||...|.|   ..|:|         .|
Human  1343 AEPPPRPPPPPPPTG---------------------QMNGTVDHPPPAAPERKPLGTAPHCPRLP 1386

  Fly  2481 QQSHFLDN---------SNSNNMMGNSNHMSDLFPNGCIDKSNQSTT------SSSNSSCVSESL 2530
            .:..:.:|         :.:....|.|       |.....|.:::|:      ::.........|
Human  1387 LRKTYRENVGGPGAPEGTPAGRARGGS-------PAPLPAKVDEATSGLIRELAAVEDELYQRML 1444

  Fly  2531 PGSNPVKTVSSCSG----QREQPVVMDAD-QQNEHPAISE-FFSSDSDVQKSVETRLEAMFGESP 2589
            .|..|....|:..|    ..|.|.:..|. :::|.|.:.: .|||||....::...|::      
Human  1445 KGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQDDTLTEHLQS------ 1503

  Fly  2590 VHLDVKSSNDANDIESNLDEIFGDSKSPAANH 2621
                      |.|...||.:..|.:.:|:..|
Human  1504 ----------AIDSILNLQQAPGRTPAPSYPH 1525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11873NP_001263051.1 GLTSCR1 2170..2271 CDD:291902 28/103 (27%)
BICRANP_001381301.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 53..99 12/57 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 624..688 17/87 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 723..949 63/306 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 974..1028 17/72 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1049..1075 5/25 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1215..1300 14/102 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1324..1424 19/132 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1440..1560 23/102 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11833
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - oto89835
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15572
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5333
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
44.130

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