Protein Alignment Bicra and Bicra

DIOPT Version :10

• Sequence 1: NP_001263051.1
• Gene: Bicra / 43435
• FlyBaseID: FBgn0039633
• Length: 3003
• Species: Drosophila melanogaster
• Sequence 2: NP_001099696.2
• Gene: Bicra / 292622
• RGDID: 1306385
• Length: 1576
• Species: Rattus norvegicus
• Alignment Length: 1831
• Identity: 388/1831 - (21%)
• Similarity: 620/1831 - (33%)
• Gaps: 535/1831 - (29%)

  Fly   954 NISLPSMTLQPQVAPAPVVTPTPAPSSNQVSTTVVVKPRRKPAVRRNAKKPDVTSSASNMISSSS 1018
            ||:..::..:.::...|...||..|:......|                      .|:...:.::
  Rat   112 NITEQTLEAEAELDLGPFQLPTLQPADGGAGAT----------------------GAAGAAAVTA 154

  Fly  1019 GTTTTISSSTSTILNNSQPTTVNTITLTTPTPVTSSSNSTLMLTHGTPTAVPSQIGNIQISQVHN 1083
            |.......|...:...:.||.:....|..|..|.:.:.|.      .|...|..:||:.:..:..
  Rat   155 GPQALFPGSADLLGLQAPPTVLTHQALVPPQDVVNKALSV------QPFLQPVGLGNVTLQPIQG 213

  Fly  1084 HHPSALPVSSAVENKIQIMPILPPGATVMGGTPGTGGHAPTTQSTQLVFQPAAPSVAPTITSDST 1148
                           :|.:|...||    |.|..|.|.||    .|:|.||......||
  Rat   214 ---------------LQGLPNGSPG----GATAATLGLAP----IQVVGQPVMALNPPT------ 249

  Fly  1149 GFKLSSDGRQMQLVAIPQATPPSPAASSAQPPVPTPTPALTAGGATILPPQLTG------MPANV 1207
                      .||:|  :..|.|...:||..| ..|....:||    :.||..|      :||.|
  Rat   250 ----------SQLLA--KQVPVSGYLASAAGP-SEPVTLASAG----VSPQGAGLVIQKNLPAAV 297

  Fly  1208 SVSVGSPASAAALVPQLTGSLTLTVSEQCERLILRHDPNNPQDHQSQLILQALLKGALPNVTIIN 1272
            :.::...:..|.     |||.|...|                             || |:    .
  Rat   298 TTTLNGNSVFAG-----TGSATAAAS-----------------------------GA-PS----G 323

  Fly  1273 EPTRVDPNKQTTPMLQPQQQVI-QIPQPLTQPQQILQQQPKVSTAPKIEVKVANNRKLSGQVTHP 1336
            :|..|.|...|:|::|....:: :.|.|       :|.:|.....||:.           |:|..
  Rat   324 QPLAVAPGLGTSPLVQAPNVILHRTPTP-------IQPKPAGVLPPKLY-----------QLTPK 370

  Fly  1337 ASSMLGMTSTT-----TTMSTMKPPANL------PAKQNEVV-SFPQLPLNSQVLIQQQPMISAQ 1389
            ..:..|.|.|.     |.....|.|.||      .|.||.|: |||...|.:.|.  :||
  Rat   371 PFTPTGATLTIQGEPGTLPQQPKAPQNLTFMAAGKAGQNVVLSSFPAPALQANVF--KQP----- 428

  Fly  1390 LQPQLQPVTVPVSLPTQPVPIPSPAPAPQLANNGQQRYIALPPIDPTTQQLFCLNSVT-----NQ 1449
                  |||...:.|.||....|...:..|.|.|....|....:.|...| |.|...:     ..
  Rat   429 ------PVTTTGTAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQ-FLLPGTSAVQLPQS 486

  Fly  1450 ITAMSA---GQ--TAASIGPTERLLIAPAGINAQQLAQCLQLGQLHFNDVNPLPAQQQQQQVATT 1509
            ::|:.|   ||  |||:.....:|:..|...| |.||..|.||        |:.|....   |.:
  Rat   487 LSALPANVGGQILTAAAPHAGGQLIANPILTN-QNLAGPLSLG--------PVLAPHSG---AHS 539

  Fly  1510 SSSMTLSMPLR-PQPPQQQIVHPIQPITNGLAITTTASSTLTTTTSTTSLTTVTKQVANVAPIID 1573
            ::.:..:.|:: .||...|:  |:...|..|  .|.:....|..|:||.|..||...:.|| :::
  Rat   540 AAHILSAAPIQVGQPALFQM--PVSLATGSL--PTQSQPAPTGPTATTVLQGVTLPPSAVA-MLN 599

  Fly  1574 QSKAKLEPA-KAATSGAGGGAVVKKKPVRKPKATPTNASELANLKNASVVKPMPKLDPLSQKPNN 1637
            .....::|: .|||:|               :|||..|.:.|.....:|..|:|.  .|.|.|..
  Rat   600 TPDGLVQPSTPAATTG---------------EATPVLAVQPATQVPPAVTTPLPM--GLQQSPAQ 647

  Fly  1638 NPVQI---------------VQPNVASGKQMIVVGSSSCTTTTTTTMSASIQPF---------QT 1678
            .|.|.               ..|.:||..:.||:|.:....||......|:|.|         .:
  Rat   648 QPPQAPTPQAATQPQATPPQASPGLASSPEKIVLGQAPPAATTAILTQDSLQMFLPQERSQQPLS 712

  Fly  1679 TSGTKL-----VGVTVPMQQQQP------TGTAAILQQQQQQRTSFSLTATTVATPAPMPSPTVA 1732
            |.|..|     |.|:.|...|.|      |..|.:..|....|.| ...|..:...||:.:|..|
  Rat   713 TEGPHLSVPASVIVSAPPPAQDPALATPVTKGAGLGAQTPDNRAS-PAPAPQIPAAAPLKAPGPA 776

  Fly  1733 SGVS---QLQMQQLPSQQAQQQLQPQQQQQLHAPKQQQPQPNTVSRVQTIQLTPQMQQIFKQVQM 1794
            |..|   |..:...|...:....:|..:      ...:|.....|:.|::...|
  Rat   777 SSPSLPHQAPLGDSPHMPSPHPARPPSR------PPSRPHSRPPSQPQSLTCPP----------- 824

  Fly  1795 QIQFLTIKLQNKSTFLPVSPEIDSATIAAYNKPMTDAEINLALQRLFAEQHRILASGKEVPTPEG 1859
                      ::.|..|..|.....|                |..:|..|:::.|     |.|..
  Rat   825 ----------SEPTLHPCPPPQGPPT----------------LPGIFVIQNQLGA-----PPPAS 858

  Fly  1860 M-LPTANGTGGFSLMPQPVQQQQQQQQQQLQSTVPE-PLKTIVPANVVQPNNHSSTPAGAATSGA 1922
            . .|||.|.      |||..:...|.        || ||.   ||:.:.|   :|||:..|:|..
  Rat   859 TPAPTAPGP------PQPPLRPPSQP--------PEGPLP---PASHLPP---ASTPSAVASSSE 903

  Fly  1923 TTAANIQQNITQRIHIYPMQHQQQQQQQQQQQQQQPQHQQQQPQHQLQQTGAKPKQAQPKPPPQQ 1987
            .:.         |:.:                 ..|...|..|       |..|.:: |.|||
  Rat   904 PST---------RLPV-----------------PTPPDFQFPP-------GQGPHKS-PTPPP-- 932

  Fly  1988 EQQSQLQIKPKEPANRSKVTSQQLQQNPQPPNGTINMLPQKVSMMPVVQQQQQQQPQQHQQQP-- 2050
                .|.:.|:..|            .|.||..|..|:......:|    |.:...::..|.|
  Rat   933 ----ALHLVPEPTA------------PPPPPPRTFQMVTAPFPALP----QPKALLERFHQVPSG 977

  Fly  2051 --MLNKSGPPPLIFASSTNMLSNSNSNNLHNSNSAMQVNNMLPLPPLQPQQQPQPQLQQP-PTPI 2112
              :.||:|..|....:||.:      ..|.:..:::.|:..  .||..|..........| .|..
  Rat   978 IILQNKAGGTPTTPQTSTTL------GTLTSPTASVLVSGQ--APPGTPAASSHAPASTPMATTG 1034

  Fly  2113 LPPV-----------APTMAMGVA----PG--PMGNLVPSLPTIPSLPLYMPSKMDEMPTQKPKI 2160
            |||:           .||:::..|    ||  |.......|.::...||..|||.
  Rat  1035 LPPLLPAENKAFASNLPTLSVAKATVSGPGKSPAMQYDSKLGSLKKQPLLQPSKE---------- 1089

  Fly  2161 ARLSLFVRQLEVDQESCLKPDYVKPFRTKDEAVKRLIRYHCMHENDVELPSD---EDEEFESTAL 2222
               :.|:..|...|.|.|.|||...|.:.::|:.||:.|| :::..:..|:|   .|||||:.:.
  Rat  1090 ---ACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYH-VYQGALPSPNDYHKVDEEFETVST 1150

  Fly  2223 EFQDKFRQLNGKFQEILMQESTLPHRTSELLQMQQLMIDDLKGEINEIRTAEKELEQQLKEEQTS 2287
            :...:.:.:..|::.:|::||.....::|::.:.::.|.:.|..:        .|::||.:|:..
  Rat  1151 QLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEEKTTL--------ALDKQLAKEKPD 1207

  Fly  2288 EKSTAESDVLSEAKVKEEIKQEPIDKSAQPDGVVDKFDLLKNSADVNKAFSKSQPQQTTTVKQEE 2352
            |..::...:.....|..|..:.|   |..|          .:|:..:...::..|...|.:....
  Rat  1208 EYVSSSRSLGFPVPVSSEGHRLP---SHGP----------SSSSSTSGTSAQPPPHPPTKLVIRH 1259

  Fly  2353 SNESGEPSV-----NGSVKSEGHDKESSKY---IKKDYD------------NFDIESELTTSFIM 2397
            ....|.|||     :.|:.|......||..   :..|.|            .::..|.:.   :.
  Rat  1260 GGAGGSPSVTWARASSSLSSTSSSSSSSSVASSLDADEDGPMPSRSRPPIKTYEARSRIG---LK 1321

  Fly  2398 KKVENKAALAKSAENRYQERNMMD--QQQQQQHIKANGGDPVDQDDGWYCLQKELNLMNNDH--- 2457
            .|::.:|.|:|...|     ..:|  .|.......|.|.:|                  ..|
  Rat  1322 LKIKQEAGLSKVVHN-----TALDPVHQPLPAPTPAKGAEP------------------PPHPAP 1363

  Fly  2458 ---MQQSQQQLNGNQQH-LPINRQPA--------PQQSHFLDN----SNSNNMMGNSNHMSDLFP 2506
               ...:|.|:||...| .||.|:|.        |.:..:.:|    |.:....|.......  |
  Rat  1364 PPLPPATQAQMNGTLDHPPPIVRKPTVPASCPRLPLRKTYRENMGDPSATEGAQGRPRGAGS--P 1426

  Fly  2507 NGCIDKSNQSTTSSSNS-SCVSESL------PGSNPVKTVSSCSGQR------EQPVVMDAD-QQ 2557
            .....|.:::|:..... :.|.:.|      .|..|.:|.:|.:.|.      |.|::.... ::
  Rat  1427 TPLPTKVDEATSGLIRELAAVEDELYQRVLKGGPPPPETPASATSQGPTESGWEAPMLPPTKRRK 1491

  Fly  2558 NEHPAISE-FFSSDSDVQKSVETRLEAMFGESPVHLDVKSSNDANDIESNLDEIFGDSKSPAANH 2621
            :|.|.:.: .|||||....::...|::.. :|.::|.............:.....|...|||..|
  Rat  1492 SESPDVDQASFSSDSPQDDTLTEHLQSAI-DSILNLQQAPGRTPAGPYPHTGPTPGTPTSPAPLH 1555

  Fly  2622 KSKMSMWVPDA 2632
            :       |||
  Rat  1556 R-------PDA 1559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bicra	NP_001263051.1	PHA03247	<753..1222	CDD:223021	54/273 (20%)
		GLTSCR1	2173..2271	CDD:464589	26/100 (26%)
		SCP-1	<2212..2476	CDD:114219	55/295 (19%)
Bicra	NP_001099696.2	PHA03247	<569..1036	CDD:223021	118/517 (23%)
		GLTSCR1	1099..1200	CDD:464589	19/100 (19%)
		dnaA	1381..>1559	CDD:455861	32/197 (16%)