DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11873 and Bicra

DIOPT Version :9

Sequence 1:	NP_001263051.1	Gene:	CG11873 / 43435	FlyBaseID:	FBgn0039633	Length:	3003	Species:	Drosophila melanogaster
Sequence 2:	NP_001074887.1	Gene:	Bicra / 243842	MGIID:	2154263	Length:	1578	Species:	Mus musculus

Alignment Length:	1841	Identity:	389/1841 - (21%)
Similarity:	613/1841 - (33%)	Gaps:	553/1841 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   954 NISLPSMTLQPQVAPAPVVTPTPAPSSNQVSTTVVVKPRRKPAVRRNAKKPDVTSSASNMISSSS 1018
            ||:..::..:.::...|...||..|:.|....|                      .|:...:.::
Mouse   112 NITEQTLEAEAELDLGPFQLPTLQPADNGAGAT----------------------GAAGATAVTA 154

  Fly  1019 GTTTTISSSTSTILNNSQPTTVNTITLTTPTPVTSSSNSTLMLTHGTPTAVPSQIGNIQISQVHN 1083
            |.......|...:...:.||.:....|..|..|.:.:.|.      .|...|..:||:.:.
Mouse   155 GPQALFPGSADLLGLQAPPTVLTHQALVPPQDVVNKALSV------QPFLQPVGLGNVTLQ---- 209

  Fly  1084 HHPSALPVSSAVENKIQIMPILPPG---ATVMGGTPGTGGHAPTTQSTQLVFQPAAPSVAPTITS 1145
                  |:|.     :|.:|...||   |..:|.||           .|:|.||......||
Mouse   210 ------PISG-----LQGLPNGSPGNAAAATLGLTP-----------IQVVGQPVMALNPPT--- 249

  Fly  1146 DSTGFKLSSDGRQMQLVAIPQATPPSPAASSAQP--PVPTPTPALTAGGATI-----LPPQLT-- 1201
                         .||:| .|.......||:|.|  ||...:..::..||.:     ||..:|
Mouse   250 -------------SQLLA-KQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKNLPAAVTTT 300

  Fly  1202 --------GMPANVSVSVGSPASAAALVPQLTGSLTLTVSEQCERLILRHDPNNPQDHQSQLILQ 1258
                    |..|..:.:.|:|:.....|....|:..|.   |...:||...|...|.
Mouse   301 LNGNSVFAGTGAATAAASGAPSGQPLAVAPGLGTSPLV---QAPSVILHRTPTPIQP-------- 354

  Fly  1259 ALLKGALPNVTIINEPTRVDPNK--QTTPM-LQPQQQVIQIP-QPLTQPQQILQQQPKVSTAPK- 1318
                          :||.|.|:|  |.||. ..|....:.|. :|.|.|     ||||   ||:
Mouse   355 --------------KPTGVLPSKLYQLTPKPFPPTGATLTIQGEPGTLP-----QQPK---APQN 397

  Fly  1319 ----IEVKVANNRKLSGQVTHPASSMLGMT-----STTTTMSTMKPPANLPAKQNEVVSFPQLPL 1374
                ...|...|..|||   .||.::....     .|||..:..:||..|    ::.:|...|..
Mouse   398 LTFMATGKAGQNVVLSG---FPAPALQANVFKQPPVTTTGTAPPQPPGAL----SKPMSVHLLNQ 455

  Fly  1375 NSQVLIQQQPMISAQLQPQLQPVTVPVSLPTQPVPIPSPAPAPQLANNGQQRYIALPPIDPTTQQ 1439
            .|.::|..|.|:..|.| .|.|.|..|.||.....:|        ||.|.|...|..|  ....|
Mouse   456 GSSIVIPAQHMLPGQNQ-FLLPGTPAVQLPQSLSALP--------ANVGGQILTAAAP--HAGGQ 509

  Fly  1440 LFCLNSVTNQITAMSAGQTAASIGPTERLLIAPAGINAQQLAQCL-----QLGQLHFNDVNPLPA 1499
            |.....:|||..|     ...|:||    ::||.. .|...|..|     |:||         ||
Mouse   510 LIANPILTNQNLA-----GPLSLGP----VLAPHS-GAHSAAHILSAAPIQVGQ---------PA 555

  Fly  1500 QQQQQQVATTSSSMTLSMPLRPQPPQQQIVHPIQPITNGLAITTTASSTLTTTTSTTSLTTVTKQ 1564
            ..|.     ..|..|.|:|.:.||.      |..|                  |:||.|..||..
Mouse   556 LFQM-----PVSLATGSLPTQSQPA------PTGP------------------TATTVLQGVTLP 591

  Fly  1565 VANVAPIIDQSKAKLEPA-KAATSGAGGGAVVKKKPVRKPKATPTNASELANLKNASVVKPMPK- 1627
            .:.|| :::.....::|: .|||:|               :|||..|.:.|.....:|..|:|.
Mouse   592 PSAVA-MLNTPDGLVQPSTPAATTG---------------EATPVLAVQPATQVPPAVTTPLPMG 640

  Fly  1628 -LDPLSQKPNNNPV-----------QIVQPNVASGKQMIVVGSSSCTTTTTTTMSASIQPF---- 1676
             ..|.:|:|...|.           ....|::||..:.||:|.:....||......|:|.|
Mouse   641 LQQPQAQQPPQVPTPQAATQPQATPPQASPSLASSPEKIVLGQAPPAATTAILTQDSLQMFLPQE 705

  Fly  1677 -----QTTSGTKL-----VGVTVPMQQQQP------TGTAAILQQQQQQRTSFSLTATTVATPAP 1725
                 .:|.|..|     |.|:.|...|.|      |..|.:..|....|.| ...|..:...||
Mouse   706 RSQQPLSTEGPHLSVPASVIVSAPPPAQDPALATPVTKGAGLGAQTPDSRAS-PAPAPQIPAAAP 769

  Fly  1726 MPSPTVASGVS---QLQMQQLPSQQAQQQLQPQQQQQLHAPKQQQPQPNTVSRVQTIQLTPQMQQ 1787
            :.:|..||..|   |..:...|...:....:|..:      ...:|.....|:.|::...|
Mouse   770 LKAPGPASSPSLPHQAPLGDSPHMPSPHPARPPSR------PPSRPHSRPPSQPQSLTCPP---- 824

  Fly  1788 IFKQVQMQIQFLTIKLQNKSTFLPVSPEIDSATIAAYNKPMTDAEINLALQRLFAEQHRILASGK 1852
                             ::.|..|..|.....|                |..:|..|:::.|
Mouse   825 -----------------SEPTLHPCPPPQGPPT----------------LPGIFVIQNQLGA--- 853

  Fly  1853 EVPTPEGMLPTANGTGGFSLMPQPVQQQQQQQQQQLQSTVPE-PLKTIVPANVVQPNNHSSTPAG 1916
               .|....|.:...|    .|||..:...|.        || ||.   ||:.:.|   :|||:.
Mouse   854 ---PPPASTPASTAPG----PPQPPLRPPSQP--------PEGPLP---PASHLPP---ASTPSA 897

  Fly  1917 AATSGATTAANIQQNITQRIHIYPMQHQQQQQQQQQQQQQQPQHQQQQPQHQLQQTGAKPKQAQP 1981
            .|:|...:|         |:.:                       ...|..|||...::.....|
Mouse   898 VASSSEPSA---------RLPV-----------------------PTPPDFQLQFPPSQGPHKSP 930

  Fly  1982 KPPPQQEQQSQLQIKPKEPANRSKVTSQQLQQNPQPPNGTINMLPQKVSMMPVVQQQQQQQPQQH 2046
            .|||      .|.:.|:..|            .|.||..|..|:......:|    |.:...::.
Mouse   931 TPPP------ALHMVPEPTA------------PPPPPPRTFQMVTAPFPALP----QPKALLERF 973

  Fly  2047 QQQP----MLNKSGPPPLIFASSTNMLSNSNSNNLHNSNSAMQVNNMLPLPPLQPQQQPQPQLQQ 2107
            .|.|    :.||:|..|....:||.:      ..|....:::.|:..  .||..|..........
Mouse   974 HQVPSGIILQNKAGGTPTTPQTSTTL------GTLTGPTASVLVSGQ--APPGTPAASSHVPAST 1030

  Fly  2108 P-PTPILPPV-----------APTMAMGVA----PG--PMGNLVPSLPTIPSLPLYMPSKMDEMP 2154
            | .|..|||:           .||:::..|    ||  |.......|.::...||..|||.
Mouse  1031 PMATTGLPPLLPAENKAFASNLPTLSVAKATVSGPGKPPAIQYDSKLCSLKKQPLLQPSKE---- 1091

  Fly  2155 TQKPKIARLSLFVRQLEVDQESCLKPDYVKPFRTKDEAVKRLIRYHCMHENDVELPSD---EDEE 2216
                     :.|:..|...|.|.|.|||...|.:.::|:.||:.|| :::..:..|:|   .|||
Mouse  1092 ---------ACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYH-VYQGALPSPNDYHKVDEE 1146

  Fly  2217 FESTALEFQDKFRQLNGKFQEILMQESTLPHRTSELLQMQQLMIDDLKGEINEIRTAEKELEQQL 2281
            ||:.:.:...:.:.:..|::.:|::||.....::|::.:.::.|.:.|..:        .|::||
Mouse  1147 FETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEEKTTL--------ALDKQL 1203

  Fly  2282 KEEQTSEKSTAESDVLSEAKVKEEIKQEPIDKSAQPDGVVDKFDLLKNSADVNKAFSKSQPQQTT 2346
            .:|:..|..::...:.....|..|..:.|....:             :|:..:...::..|...|
Mouse  1204 AKEKPDEYVSSSRSLGFPVPVSSEGHRLPSHGQS-------------SSSSTSGTSAQPPPHLPT 1255

  Fly  2347 TVKQEESNESGEPSVN--------GSVKSEGHDKESSKYIKKDYD------------NFDIESEL 2391
            .:........|.|||.        .|..|......::..:..|.|            .::..|.:
Mouse  1256 KLVIRHGGAGGSPSVTWARASSSLSSTSSSSSSSSAASSLDADEDGPMPTRNRPPIKTYEARSRI 1320

  Fly  2392 TTSFIMKKVENKAALAKSAENRYQERNMMD--QQQQQQHIKANGGDPVDQDDGWYCLQKELNLMN 2454
            .   :..|::.:|.|:|...|     ..:|  .|.......|.|.:|
Mouse  1321 G---LKLKIKQEAGLSKVVHN-----TALDPVHQPLPAPTPAKGAEP------------------ 1359

  Fly  2455 NDH------MQQSQQQLNGNQQH-LPINRQPA--------PQQSHFLDNSNSNNMMGNSNHMSDL 2504
            ..|      ...:|.|:||...| .|..|:|.        |.:..:.:|      |||.......
Mouse  1360 PPHPAPPPLPPATQAQMNGTLDHPPPAVRKPTVPASCPRLPLRKTYREN------MGNPGAAEGA 1418

  Fly  2505 --------FPNGCIDKSNQSTTSSSNS-SCVSESL------PGSNPVKTVSSCSGQR------EQ 2548
                    .|.....|.:::|:..... :.|.:.|      .|..|.:|.:|.:.|.      |.
Mouse  1419 QGRPRGAGSPTPLPTKVDEATSGLIRELAAVEDELYQRVLKGGPPPPETPASATSQGPTEPSWEA 1483

  Fly  2549 PVVMDAD-QQNEHPAISE-FFSSDSDVQKSVETRLEAMFGESPVHLDVKSSNDANDIESNLDEIF 2611
            ||:..|. :::|.|.:.: .|||||....::...|::.. :|.::|.............:.....
Mouse  1484 PVLPPAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAI-DSILNLQQAPGRTPAGPYPHTGPTP 1547

  Fly  2612 GDSKSPAANHKSKMSMWVPDA 2632
            |...|||..|:       |||
Mouse  1548 GTPTSPAPLHR-------PDA 1561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11873	NP_001263051.1	GLTSCR1	2170..2271	CDD:291902	27/103 (26%)
Bicra	NP_001074887.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..101
		PHA03247	<321..935	CDD:223021	190/834 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..673		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..951		66/343 (19%)
		GLTSCR1	1101..1202	CDD:373682	27/109 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1206..1316		16/122 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1342..1435		20/116 (17%)
		dnaA	1383..>1561	CDD:237605	38/191 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1457..1578		27/113 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	114	1.000	Inparanoid score	I4834
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43303
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15572
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5333
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.180