DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11873 and BICRAL

DIOPT Version :9

Sequence 1:	NP_001263051.1	Gene:	CG11873 / 43435	FlyBaseID:	FBgn0039633	Length:	3003	Species:	Drosophila melanogaster
Sequence 2:	NP_001305748.1	Gene:	BICRAL / 23506	HGNCID:	21111	Length:	1079	Species:	Homo sapiens

Alignment Length:	1320	Identity:	253/1320 - (19%)
Similarity:	448/1320 - (33%)	Gaps:	426/1320 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1325 NNRKLSGQVTHPASSMLGMTSTTTTMSTMKPPANLPAKQNEVVSFPQ--LPLNSQVLIQQQPMIS 1387
            :|:..:..:|:...|.....|.....|...|.::|....|::...|.  |||:|.:...:..:.|
Human    27 SNKSSNDDLTNAGYSAANSNSIFANSSNADPKSSLKGVSNQLGEGPSDGLPLSSSLQFLEDELES 91

  Fly  1388 AQLQPQL---QPVTVPVSLPTQPVPIPSPAPAPQL---ANNGQQRYIALPPIDPTTQQLFC-LNS 1445
            :.| |.|   ||..: :....|...|.....|.:.   |:.|..:..|...:.|::...|. .::
Human    92 SPL-PDLTEDQPFDI-LQKSLQEANITEQTLAEEAYLDASIGSSQQFAQAQLHPSSSASFTQASN 154

  Fly  1446 VTNQITAMSAGQTAASIGPTERLLIAPAGINAQQLAQCLQLGQLHFNDVNPLPAQQQQQQVATTS 1510
            |:|.     :|||...||.|.    .|.|.:.......:|.|.:....:: :|:|........:.
Human   155 VSNY-----SGQTLQPIGVTH----VPVGASFASNTVGVQHGFMQHVGIS-VPSQHLSNSSQISG 209

  Fly  1511 SSMTLSMPLRPQPPQQQIV-----HPIQPITNGLAITTTASSTLTTTTSTTSLTTVTKQVANVAP 1570
            |.            |.|::     ||                         |:.|:..
Human   210 SG------------QIQLIGSFGNHP-------------------------SMMTINN------- 230

  Fly  1571 IIDQSKAKLE-PAKAATSGAGGGAVVKKKPVRKPKATPTNASELANLKNASVVKP---------- 1624
             :|.|:..|: ..:.|.|...||.:|.::       ||...|...|..::.|.:|
Human   231 -LDGSQIILKGSGQQAPSNVSGGLLVHRQ-------TPNGNSLFGNSSSSPVAQPVTVPFNSTNF 287

  Fly  1625 ---MPKLDPLSQK---PNNNPVQI-VQPN-VASGKQMIVVGSSSCTTTTTTTMSASIQPFQTTSG 1681
               :|..:.:.|:   ||:|.|.| :||. :..|:|           .|....:..||......|
Human   288 QTSLPVHNIIIQRGLAPNSNKVPINIQPKPIQMGQQ-----------NTYNVNNLGIQQHHVQQG 341

  Fly  1682 TKLVGVTVPM-QQQQPTGTAAILQQQQQQR--TSFSLTAT--TVATPAPMPSPTVASGVSQLQMQ 1741
            ......:.|. ....|..:..|:.||..::  ||.::::|  ::...:||..|
Human   342 ISFASASSPQGSVVGPHMSVNIVNQQNTRKPVTSQAVSSTGGSIVIHSPMGQP------------ 394

  Fly  1742 QLPSQQAQQQLQPQQQQQLHAPKQQQPQP-------NTVSRVQTI--QL--TPQMQQIFKQVQMQ 1795
                               |||:.|...|       |:|..||||  ||  |...|.|..||..:
Human   395 -------------------HAPQSQFLIPTSLSVSSNSVHHVQTINGQLLQTQPSQLISGQVASE 440

  Fly  1796 IQFLTIKLQNKSTFLPVSPEIDSATIAAYNKPMTDAE---INLALQRLFAEQHRILASGKEV--- 1854
            ...|.   :|.|..|        .|...|..||.:.:   ::|...:.||      |||..|
Human   441 HVMLN---RNSSNML--------RTNQPYTGPMLNNQNTAVHLVSGQTFA------ASGSPVIAN 488

  Fly  1855 -PTPE---GMLP-----------------TANGTGGFSLMPQPVQQQQQQQQQQLQSTVPEPLKT 1898
             .:|:   |.:|                 .:.|..||:.||.....           :.|.....
Human   489 HASPQLVGGQMPLQQASPTVLHLSPGQSSVSQGRPGFATMPSVTSM-----------SGPSRFPA 542

  Fly  1899 IVPANVVQPNNHSSTPAGAATSGATTAANIQQNITQRIHIYPMQHQQQQQQQQQQQQQQPQHQQQ 1963
            :..|:...|:      .|:|....::.:|.
Human   543 VSSASTAHPS------LGSAVQSGSSGSNF----------------------------------- 566

  Fly  1964 QPQHQLQQTGAKPKQAQPKPPPQQEQQSQLQIKPKEPANRSKVTSQQLQQNPQPPNGTINMLPQK 2028
                    ||.:..|....|.|       :.:..:.|.:.||.||   ..:..|..||
Human   567 --------TGDQLTQPNRTPVP-------VSVSHRLPVSSSKSTS---TFSNTPGTGT------- 606

  Fly  2029 VSMMPVVQQQQQQQPQQHQQQPMLNKSGPPPLIFASSTN------MLSNSNSNNLHNSNSAMQVN 2087
                       |||.....|:..||::.|   |.|..|.      .:....|..|...:|..:|.
Human   607 -----------QQQFFCQAQKKCLNQTSP---ISAPKTTDGLRQAQIPGLLSTTLPGQDSGSKVI 657

  Fly  2088 NMLPLPPLQPQQQPQPQLQQPPTPILPPVAPTMAMGVAPGPMGNLVPSLPTIPSLPLYMPSKMDE 2152
            : ..|...||||:                              .:|.|.|..|::.:...|...:
Human   658 S-ASLGTAQPQQE------------------------------KVVGSSPGHPAVQVESHSGGQK 691

  Fly  2153 MPTQKPKIARLSLFVRQLEVDQESCLKPDYVKPFRTKDEAVKRLIRYHCMHENDVELPSDE---- 2213
            .|..| ::.:.:..::||:.||...:.|| ...||:..:||:||:.||....:   :|::|
Human   692 RPAAK-QLTKGAFILQQLQRDQAHTVTPD-KSHFRSLSDAVQRLLSYHVCQGS---MPTEEDLRK 751

  Fly  2214 -DEEFESTALEFQDKFRQLNGKFQEILMQESTLPHRTSELLQMQQLMIDDLKGEINEIRTAEKEL 2277
             |.|||:.|.:...:.:.:..|::.:|::::...:.::|::.:.::...:.:..::.    :|.|
Human   752 VDNEFETVATQLLKRTQAMLNKYRCLLLEDAMRINPSAEMVMIDRMFNQEERASLSR----DKRL 812

  Fly  2278 -----------------------EQQL-KEEQTSEKSTAESDVLSEAKVKEEIK---QEPIDKSA 2315
                                   |.|. :.:|...|:::.....::|:.::..|   .||::.
Human   813 ALVDPEGFQADFCCSFKLDKAAHETQFGRSDQHGSKASSSLQPPAKAQGRDRAKTGVTEPMNH-- 875

  Fly  2316 QPDGVVDKFDLLKN----SADVNKA-----------FSK---SQPQQTTTVKQEESNESGEP--S 2360
                  |:|.|:.|    ||:.|.:           |.|   .|.|.|:    ||.....||  :
Human   876 ------DQFHLVPNHIVVSAEGNISKKTECLGRALKFDKVGLVQYQSTS----EEKASRREPLKA 930

  Fly  2361 VNGSVKSEGHDKESSKYIKKDYDNFDIESELTTSFIMKKVENKAALAKSAENRYQERNMMDQQQQ 2425
            ...|...|||.|.||:      .:...||:|::      :...:.|..:..|.:|::::.:..:.
Human   931 SQCSPGPEGHRKTSSR------SDHGTESKLSS------ILADSHLEMTCNNSFQDKSLRNSPKN 983

  Fly  2426 Q---QHIKANGGDPVDQDDGWYCLQKELNLMNNDHMQQSQQQLNGNQQHLPINRQPAPQQSHFLD 2487
            :   ..|....|:|  |.|.......|....|...::::.:|...:         |....|..||
Human   984 EVLHTDIMKGSGEP--QPDLQLTKSLETTFKNILELKKAGRQPQSD---------PTVSGSVELD 1037

  Fly  2488 NSNSNNMMGNSNHMSDLFPN 2507
            ..|.:.|....|.:....|:
Human  1038 FPNFSPMASQENCLEKFIPD 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11873	NP_001263051.1	GLTSCR1	2170..2271	CDD:291902	23/105 (22%)
BICRAL	NP_001305748.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..79		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..604		22/164 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	669..691		5/51 (10%)
		GLTSCR1	711..811	CDD:405846	22/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..877		7/47 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	917..954		13/46 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11833
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I5125
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15572
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.150