Protein Alignment Cul5 and RTT101

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_012488.3
• Gene: RTT101 / 853400
• SGDID: S000003583
• Length: 842
• Species: Saccharomyces cerevisiae
• Alignment Length: 663
• Identity: 132/663 - (19%)
• Similarity: 244/663 - (36%)
• Gaps: 176/663 - (26%)

  Fly   258 VRESYVNLSSNAEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQE-------------NGVLAYM 309
            :|:.|.. .||...:||.:: ||:: .|........|.|.|...:             ..:..|:
Yeast   271 LRQYYCE-ESNLRPRLETFK-NFKV-LLTRNALLASLFSPEWVSDANDLFISHLLLNKKSISEYI 332

  Fly   310 KYADSKLREEEVRAKRYLEPSS-FSILTYTLVNVLIVDHLNSIIAE-CPALIRDYETERLNLMF- 371
            :.......||:   :||.:..: ||:|.:.  |.....::.|...| |.    |..:|:|...:
Yeast   333 EIGKDTYDEEK---ERYFKTETHFSLLMFR--NAFEAKNMLSKFKEFCD----DAVSEKLKAAYG 388

  Fly   372 ------RLMDRVMHGVGVEPM---MGDLQRHIMSAGLADML-SASEVITQDSEKYVERLLELFNK 426
                  ||.|.|:....|:.:   ...::.|     |.::| |.|:.|.|..:.:...|..:..|
Yeast   389 SNHDTERLFDEVVQLANVDHLKIYSDSIEYH-----LCNLLGSTSKAIEQYVKYFESHLFIIVRK 448

  Fly   427 FSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKME---LPTSIANRGVKYTAPESKCPELLANY 488
                ::....|.|     ||:..|.:..:..:.:::   |||                   ..|:
Yeast   449 ----IKTTKKDLP-----RDMKIKYLNENLPILRLKFVNLPT-------------------FPNF 485

  Fly   489 CDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDI 553
            .:..:.|..:   |.|:|..:.::|:|.|.     ||..|...|    :|:|...|     :||
Yeast   486 FERSIFRKTI---LQSDQNSSFIKDILPVY-----KDSLMELFK----QRIITNVS-----QED- 532

  Fly   554 VEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHDAINIKILNAGAWARCS------- 611
                 |:.....|...|::.||.::|..||..::.:.:|.::.|...:.....:...:
Yeast   533 -----EMRYRDQYQPYLSQFFQPVEVMADLRIKYASFLSFYENIEAAVKFGKTYNENNSKSFFPL 592

  Fly   612 ----ERV------------SVSLPIELEDYIPDVEEFYKKKHSGRKLQ------------W-YHH 647
                ||:            :..||.|::|   ...:|.:..|...|::            | .||
Yeast   593 IFDRERIPKVFQQSNEVKKNFVLPQEMDD---TWNQFLRNYHEQNKVEDSDASKKELYPMWNLHH 654

  Fly   648 MSNGTITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFP 712
            ....:...:.:......::|.||..||..:|:..|  ::.:.:...|:|...:|...|.|...:.
Yeast   655 CEVESPYIIQDGTNLIFELTLFQTCVLTLFNESDH--LTLQVISEQTKLAYKDLALVLKSFCNYK 717

  Fly   713 KIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLI----GRLQLS------ 767
            .:.:.|               :|| :.||:.|.  .:.|..:.|||.::    ..||.|
Yeast   718 ILTRDI---------------DNT-YSINESFK--PDMKKVKNGKLRVVLPRTASLQSSNTGGER 764

  Fly   768 TERSQQEDNQSIVQLRILRTQEAIIK--IMKVRKRMNNAALQGELIDILKNMFLP-SKKMIKEQL 829
            |..:..|.:.|      ..||| ::|  |.:..|...|......|.:.:|..... |....|:.|
Yeast   765 TSSAHHEGSNS------QWTQE-LLKACITRSVKSERNGLDYDHLFETVKQQIKGFSVGEFKDAL 822

  Fly   830 EWLIENKYMRRDD 842
            ..|:.:|::.||:
Yeast   823 AKLLRDKFITRDE 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	105/549 (19%)
		CULLIN	520..655	CDD:214545	31/170 (18%)
		Cullin_Nedd8	779..846	CDD:214883	16/67 (24%)
RTT101	NP_012488.3	COG5647	<519..842	CDD:227934	72/362 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900