Protein Alignment Cul5 and CUL3

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_011517.1
• Gene: CUL3 / 852886
• SGDID: S000003235
• Length: 744
• Species: Saccharomyces cerevisiae
• Alignment Length: 719
• Identity: 151/719 - (21%)
• Similarity: 282/719 - (39%)
• Gaps: 173/719 - (24%)

  Fly   207 PTEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQ------LVVGVRESYVNL 265
            |.....|..:.||.:...|.......|..:.:..:...||..:.|::      :::|:.|:   |
Yeast   126 PNRCMEVYDMCLDLFRIEILQKCSSSLISALISDIERIRNLGSVDSEHTSLWKVLIGMMET---L 187

  Fly   266 SSNAEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLRE-EEVRAKRYLEP 329
            ..|.:   ..:..:||...:.||.|:|. |:.:.:....:.:..|.  .|||: |.:....:|..
Yeast   188 HDNRD---SFFLTDFEPVLISATEEYYN-KAIDIELLTPIESLEKI--RKLRQFESMLDSSFLNV 246

  Fly   330 SSFSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMM---GDLQ 391
            .|.:.|...|.||||...|:.||.:                      :.|    |.|:   |.|.
Yeast   247 DSHNKLKTVLENVLIWGKLSDIIED----------------------LTH----EAMVISNGKLL 285

  Fly   392 RHIMSAGLADMLSASEVITQDSEKY----VERLLELFNKFSDLVRNAFNDDPR------------ 440
            :.|.     |:.|        .|||    :|.:....||  :.:...||:..|
Yeast   286 QEIY-----DLSS--------EEKYRVTVIESIKSYINK--NAINIPFNEGNRKKGQNAITWSSE 335

  Fly   441 ----------FLTARD---IAFKTVVNDTS------VFKMELPTSIANRGVKYTAPESKCP-ELL 485
                      ||.:.|   :....:..|.|      ||.|            |.:.|...| |.|
Yeast   336 IVELYRSQHSFLESIDFGSVRLNNLTGDVSNAILGDVFSM------------YFSKEGALPSEYL 388

  Fly   486 ANYCDMLLRRTPLSKRLTSE--QIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSE 548
            :.|.|..::||   |...:|  :|...|.|...::..:..||:|.:.:|..|:|||:...|. .|
Yeast   389 STYVDHCMKRT---KEKDAEIVKIKQDLLDSTKLIGLLTEKDIFEKIYKKQLSRRLLQQRSL-VE 449

  Fly   549 KEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHDAINI--------KILNAG 605
            .|:.:|:.:::| :...:.::|..|.:||.:|.::...|     :|..||.        ::|...
Yeast   450 IEKWMVQMIKKV-LGTFFTSKLEIMLRDISLSSEMYQAF-----QHSTINSIEYLSFAPQVLTRT 508

  Fly   606 AWARCSER---VSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRYDLDVT 667
            :|...|..   ..:|||..:...:...|.:|..|:..|.|:|.||:|...|....|.|.|::..:
Yeast   509 SWPFQSTNPIDEGISLPPRMSQILAGFEGYYSLKYKERVLKWAHHLSVIEIGCQFNSGYYEISFS 573

  Fly   668 TFQMAVLFAWNQRQHDKISYENLRLA-----TELPDPELRRTLWSLVAFPKIKKQILLMEPAAIS 727
            .:...:...:.       .||.|.|.     |.:|..:::..:.|:...|:.|    :::.::.|
Yeast   574 VYAGVIFLLFE-------DYEELTLGEIYELTHIPIDDVKSLVMSMSTIPRCK----ILKKSSSS 627

  Fly   728 SPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQ---------EDNQSIVQLR 783
            ....|:.|..|           ....|:.|:.:|. ..|.:::|..         .||:.:::|.
Yeast   628 GNMKFSVNYFF-----------SSPNRKVKVPVIA-CPLPSQKSDNLATASSVDTYDNEIVMELS 680

  Fly   784 ILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMF 848
            .:     |::|||...::::..|........::....:..::|..::.|||.:|::|:.||.:.:
Yeast   681 AI-----IVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRNADDPSYY 740

  Fly   849 IYVA 852
            .|::
Yeast   741 HYLS 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	129/599 (22%)
		CULLIN	520..655	CDD:214545	38/145 (26%)
		Cullin_Nedd8	779..846	CDD:214883	14/66 (21%)
CUL3	NP_011517.1	COG5647	1..744	CDD:227934	151/717 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810