Protein Alignment Cul5 and CUL1

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_001357589.1
• Gene: CUL1 / 8454
• HGNCID: 2551
• Length: 776
• Species: Homo sapiens
• Alignment Length: 657
• Identity: 206/657 - (31%)
• Similarity: 350/657 - (53%)
• Gaps: 56/657 - (8%)

  Fly   213 VRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAED------ 271
            :..|.|.:|...:|..:..::..:.:|::..||||:..:.:|:.||.:|||.|..|.:|
Human   159 IYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGP 223

  Fly   272 KLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILT 336
            .|.:|:|:||..:|..|..||..:|.|..|:|.|..|||.|:::|.||:.|.:.||..|:...|.
Human   224 TLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELA 288

  Fly   337 YTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLAD 401
            .....|||..||.....|...|:...:.|.|..|:.|:.|:..|:|....:  |:.||.:.|||.
Human   289 RKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKL--LETHIHNQGLAA 351

  Fly   402 MLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTS 466
            :....|....|.:.||:.:|::..|::.||.:|||:|..|:.|.|.|....:|:.:|.||
Human   352 IEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKM----- 411

  Fly   467 IANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYH 531
                    ....||.|||||.|||.||:::  ||.....:::..|..|::|.||:.:||||.:::
Human   412 --------AQSSSKSPELLARYCDSLLKKS--SKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFY 466

  Fly   532 KVHLTRRLILGTSADSEKEEDIVEWLREV-GMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHD 595
            ...|.:||:...||..:.|..::..|::. |.  :|.::|.||||||.||:|||.||:..::..:
Human   467 AKMLAKRLVHQNSASDDAEASMISKLKQACGF--EYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE 529

  Fly   596 AI----NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFV 656
            .:    :|::|::|:|. ..:..:.:||.|||........||..:||||||.|.:.:|.|.:. .
Human   530 PLDLDFSIQVLSSGSWP-FQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELV-T 592

  Fly   657 NNF-GRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILL 720
            |.| .||.|..:|||||:|..:|  ..|..:.:.|..:|::....|.:.|..|     :|.::|:
Human   593 NCFKNRYTLQASTFQMAILLQYN--TEDAYTVQQLTDSTQIKMDILAQVLQIL-----LKSKLLV 650

  Fly   721 MEPA-AISSPKDFAENTM--FYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQED--NQSIV 780
            :|.. |.....:...:|:  .|:         |...::.::|:  .:.:.||:.|:::  :::|.
Human   651 LEDENANVDEVELKPDTLIKLYL---------GYKNKKLRVNI--NVPMKTEQKQEQETTHKNIE 704

  Fly   781 QLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDI 845
            :.|.|..|.||::|||:||.:.:..|.||::..|.:.|.|...:||:.::.|||.:|:.|.|.:.
Human   705 EDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEK 769

  Fly   846 NMFIYVA 852
            :.:.|:|
Human   770 DTYSYLA 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	174/544 (32%)
		CULLIN	520..655	CDD:214545	48/139 (35%)
		Cullin_Nedd8	779..846	CDD:214883	25/66 (38%)
CUL1	NP_001357589.1	Cullin	21..660	CDD:395716	172/528 (33%)
		Cullin_Nedd8	706..767	CDD:402267	23/60 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820