DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cul5 and CUL2

DIOPT Version :9

Sequence 1:NP_651665.2 Gene:Cul5 / 43434 FlyBaseID:FBgn0039632 Length:852 Species:Drosophila melanogaster
Sequence 2:XP_011518045.1 Gene:CUL2 / 8453 HGNCID:2552 Length:808 Species:Homo sapiens


Alignment Length:860 Identity:225/860 - (26%)
Similarity:392/860 - (45%) Gaps:144/860 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCL-WDEKGAAKIYDCLQQDIVEFIVQAQS 76
            |:|.|......:..::..:.|.:..|.|.|..::.:|: :.|....::|       .|..:..::
Human    73 FDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLY-------TETKIFLEN 130

  Fly    77 QV-----QAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSASVSASGA 136
            .|     :....|:.:|..|...|.::...::|:...:|.|                        
Human   131 HVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYL------------------------ 171

  Fly   137 STSAAAAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTS 201
            :|........|....|.|..|...:                                        
Human   172 NTQFIKKNKLTEADLQYGYGGVDMN---------------------------------------- 196

  Fly   202 TSKKNPTEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLS 266
                .|..:  :.:|.||.|.|.:...::..|....::.:..:|.|:..:.:::.||..|:|::.
Human   197 ----EPLME--IGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVE 255

  Fly   267 S-NAEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPS 330
            . ..:..|:.|:|.||..:|..|.|:|:.:::...||:....||:....:|::||:|.::||.||
Human   256 QYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPS 320

  Fly   331 SFSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIM 395
            |::.:.:.....::.|||..:.|||..:||..:...:..|:.|:..|  ..|:..|:.:||.||.
Human   321 SYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLLRAV--STGLPHMIQELQNHIH 383

  Fly   396 SAGLADMLSASEVITQDS--EKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSV 458
            ..|    |.|:..:||::  ..:||.:||:..||..|:....|.|..|::|.|.|..:|||    
Human   384 DEG----LRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVN---- 440

  Fly   459 FKMELPTSIANRGVKYTAPESKC--PELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYV 521
                           |..|:|.|  |||||.|||.||:::  :|.:|..:::.||...:.|.||:
Human   441 ---------------YREPKSVCKAPELLAKYCDNLLKKS--AKGMTENEVEDRLTSFITVFKYI 488

  Fly   522 NNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQ 586
            ::||||.:::...|.:|||.|.|...:.||.::..|:: ....::.::|.||:.|:.||.|||.:
Human   489 DDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQ-ACGYEFTSKLHRMYTDMSVSADLNNK 552

  Fly   587 FRTSISRHDAI-------NIKILNAGAWARCSERVSV-SLPIELEDYIPDVEEFYKKKHSGRKLQ 643
            |...|...|.:       .|.:|.||||.......|. ::|.|||..:...|.||.:..|||||.
Human   553 FNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLT 617

  Fly   644 WYHHMSNGTITFVNNFGR-YDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWS 707
            |.|::..|.:. :|..|: |...|||:|||||.|:|  ..:.:||:.|:.:|::.:.||.:|:.|
Human   618 WLHYLCTGEVK-MNYLGKPYVAMVTTYQMAVLLAFN--NSETVSYKELQDSTQMNEKELTKTIKS 679

  Fly   708 LVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQ 772
            |:....|...         |..:|....:.|.:|..|       |.:|.|..:...:|..|.:..
Human   680 LLDVKMINHD---------SEKEDIDAESSFSLNMNF-------SSKRTKFKITTSMQKDTPQEM 728

  Fly   773 QEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKY 837
            ::...::.:.|.:..|.||::|||.||.:.:.||..|:|...:..|.||..|||:.:|.||:.:|
Human   729 EQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQY 793

  Fly   838 MRRDDDDINMFIYVA 852
            :.|.....:.:.|||
Human   794 IERSQASADEYSYVA 808

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul5NP_651665.2 Cullin 33..743 CDD:279260 189/729 (26%)
CULLIN 520..655 CDD:214545 48/142 (34%)
Cullin_Nedd8 779..846 CDD:214883 24/66 (36%)
CUL2XP_011518045.1 Cullin 93..706 CDD:279260 189/729 (26%)
CULLIN 487..631 CDD:214545 48/145 (33%)
Cullin_Nedd8 735..802 CDD:214883 24/66 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5647
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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