DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul5 and CUL3

DIOPT Version :9

Sequence 1:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001244127.1	Gene:	CUL3 / 8452	HGNCID:	2553	Length:	774	Species:	Homo sapiens

Alignment Length:	673	Identity:	174/673 - (25%)
Similarity:	321/673 - (47%)	Gaps:	95/673 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 IFHD-------IKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENFEM 282
            ||.|       |:..|:::.:.::..||.|:..|..   .:|.:...|.....:...:|.|:||.
Human   152 IFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRG---AIRNACQMLMILGLEGRSVYEEDFEA 213

  Fly   283 AYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIVDH 347
            .:|:.:.||::::|.:...||....|:|..::::.||..|....|:.|:...:...:...||..|
Human   214 PFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKH 278

  Fly   348 LNSII----AECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEV 408
            :.:|:    :....::::.:||.|..|::|..||.:  |::.|...:..::...|.|       :
Human   279 MKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPN--GLKTMCECMSSYLREQGKA-------L 334

  Fly   409 ITQDSE-----KYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIA 468
            ::::.|     .|::.||:|.::|...:..:||:|..|.       :|:..|...| :.|
Human   335 VSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFK-------QTIAGDFEYF-LNL----- 386

  Fly   469 NRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKV 533
                     .|:.||.|:.:.|..|::.  .|.||.::::..|...:::.:::..||||.||:|.
Human   387 ---------NSRSPEYLSLFIDDKLKKG--VKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQ 440

  Fly   534 HLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFR-----TSIS 592
            ||.|||:...|...:.|::::..|: |.|  ..:.::|..||:|:.:|.....:||     |.:|
Human   441 HLARRLLTNKSVSDDSEKNMISKLKTECG--CQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVS 503

  Fly   593 RHDA-INIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTI--T 654
            .... :.:::|..|.|...|.....::|............||..|||||:|...|||.:..:  |
Human   504 LGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNAT 568

  Fly   655 FV--------------------NNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDP 699
            |.                    :|..::.|.|:||||.:|..:|.|  :|.::|.::..|::|:.
Human   569 FYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNR--EKYTFEEIQQETDIPER 631

  Fly   700 ELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRL 764
            ||.|.|.|| |..|..:::|..||.:    |:.....:|.:|.:|.     ....|.|:..:...
Human   632 ELVRALQSL-ACGKPTQRVLTKEPKS----KEIENGHIFTVNDQFT-----SKLHRVKIQTVAAK 686

  Fly   765 QLSTERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQL 829
            |..::..::|..|.:...|....:.||::|||.||:|.:..|..|:...||..||||..:||:::
Human   687 QGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRI 751

  Fly   830 EWLIENKYMRRDDDDINMFIYVA 852
            |.|||.:|:.|..:|..::.|||
Human   752 EGLIEREYLARTPEDRKVYTYVA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	139/562 (25%)
		CULLIN	520..655	CDD:214545	42/143 (29%)
		Cullin_Nedd8	779..846	CDD:214883	26/66 (39%)
CUL3	NP_001244127.1	Cullin	41..670	CDD:279260	139/562 (25%)
		CULLIN	427..569	CDD:214545	42/143 (29%)
		Cullin_Nedd8	706..766	CDD:287520	24/59 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820