DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cul5 and CUL4B

DIOPT Version :9

Sequence 1:NP_651665.2 Gene:Cul5 / 43434 FlyBaseID:FBgn0039632 Length:852 Species:Drosophila melanogaster
Sequence 2:NP_003579.3 Gene:CUL4B / 8450 HGNCID:2555 Length:913 Species:Homo sapiens


Alignment Length:914 Identity:216/914 - (23%)
Similarity:382/914 - (41%) Gaps:243/914 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 SSSGSSSSAS-------VSASGAST------SAAAAAAATSCSGQA------------------- 153
            |||.|||::|       .::|.:||      .:|:.:.::.|.|.:                   
Human    61 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLRFEDTL 125

  Fly   154 -----------GKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTS------ 201
                       ..|.:|:|::..|:||......:.|...||.|:...|:|...||::.|      
Human   126 EFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSK 190

  Fly   202 --TSKK--------------NPTEDS--------------------------------------- 211
              ::||              |.|:::                                       
Human   191 PGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISAN 255

  Fly   212 ------------------PVRKLMLDS----------WNKH-----------IFHDIKHRLQESA 237
                              ..|:..|||          |..|           :|.|..:.||.|.
Human   256 LYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSM 320

  Fly   238 MK------------------------------IVHAERNGDAYDAQLVVGVRESYVNLSSNAEDK 272
            :.                              ::..||||:|.|..|:    .|.:::.|:    
Human   321 LPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLL----RSLLSMLSD---- 377

  Fly   273 LEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTY 337
            |:||:::||..:|:.|...|..:..:..||..|..|:.:.:.:|.||..|...||:.::...|..
Human   378 LQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIA 442

  Fly   338 TLVNVLIVDHLNSIIAE-CPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLAD 401
            |:...|:.:||.:|:.: ...|:.:...:.|:|:::|..||..||.|  ::.....:|.:.|   
Human   443 TVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQV--LLQQWIEYIKAFG--- 502

  Fly   402 MLSASEVITQDSEK-YVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPT 465
               ::.||..:.:| .|:.||:..:|...::...|..:.:|:.|...||:|.:|..         
Human   503 ---STIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKR--------- 555

  Fly   466 SIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRY 530
                        .:|..||:|.|.|..||..  :|..|.|:::..|..::::.:::..||||..:
Human   556 ------------PNKPAELIAKYVDSKLRAG--NKEATDEELEKMLDKIMIIFRFIYGKDVFEAF 606

  Fly   531 HKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRH 594
            :|..|.:||::|.||..:.|:.::..|: |.|  |.:.::|..||:|:::|:|:..||:..:...
Human   607 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECG--AAFTSKLEGMFKDMELSKDIMIQFKQYMQNQ 669

  Fly   595 DA-----INIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTIT 654
            :.     :.:.||..|.|..... :.|.||.|:.......:.||..|||||||||...:.:..:.
Human   670 NVPGNIELTVNILTMGYWPTYVP-MEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLK 733

  Fly   655 FVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQIL 719
            .....|:.:|.|:.||..||..:|  :.::.|.|.::.||.:.|.||||||.||...   |.::|
Human   734 AEFKEGKKELQVSLFQTLVLLMFN--EGEEFSLEEIKQATGIEDGELRRTLQSLACG---KARVL 793

  Fly   720 LMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQL-STERSQQEDNQSIVQLR 783
            ...|..    ||..:...|..|.:|.     ....|.|:|   ::|: .|...|....:.:.|.|
Human   794 AKNPKG----KDIEDGDKFICNDDFK-----HKLFRIKIN---QIQMKETVEEQASTTERVFQDR 846

  Fly   784 ILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMF 848
            ..:...||::|||:||.:::..|..|:.:.||....|:.  :|:::|.||:..||.||.::.|.:
Human   847 QYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPAD--LKKRIESLIDRDYMERDKENPNQY 909

  Fly   849 IYVA 852
            .|:|
Human   910 NYIA 913

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul5NP_651665.2 Cullin 33..743 CDD:279260 184/802 (23%)
CULLIN 520..655 CDD:214545 43/140 (31%)
Cullin_Nedd8 779..846 CDD:214883 22/66 (33%)
CUL4BNP_003579.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..100 11/38 (29%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:19801544 55..58
Cullin 218..813 CDD:279260 152/645 (24%)
CULLIN 596..736 CDD:214545 43/142 (30%)
Cullin_Nedd8 842..907 CDD:214883 22/66 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158280
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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