Protein Alignment Cul5 and CUL3B

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_177125.3
• Gene: CUL3B / 843303
• AraportID: AT1G69670
• Length: 732
• Species: Arabidopsis thaliana
• Alignment Length: 677
• Identity: 189/677 - (27%)
• Similarity: 338/677 - (49%)
• Gaps: 95/677 - (14%)

  Fly   201 STSKKNPTEDSPVRKLMLDSWNKHIFHD--IKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYV 263
            ||:||     :.|.:|.|..|..::.:.  |:.||..:.:.:||.||.|:..|..|:..|.:.::
plant   126 STTKK-----THVHELGLHLWRDNVVYSSKIQTRLLNTLLDLVHKERTGEVIDRVLMRNVIKMFM 185

  Fly   264 NLSSNAEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLE 328
            :|..:      :|:::||..:|:|:.|||:::|.|..:......|:|.|:..|.||..|...||:
plant   186 DLGES------VYQDDFEKPFLEASAEFYKVESMEFIESCDCGEYLKKAEKPLVEEVERVVNYLD 244

  Fly   329 PSSFSILTYTLVNVLIVDHLNSII-AECPALIR---DYETERLNLMFRLMDRVMHGVGVEPMMGD 389
            ..|.:.:|..:...:|.:|:..:: .|...|:.   :.:.|.:..|:.|..||.:|:..
plant   245 AKSEAKITSVVEREMIANHVQRLVHMENSGLVNMLLNDKYEDMGRMYSLFRRVANGLVT------ 303

  Fly   390 LQRHIMSAGLADMLSASEVIT-----QDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAF 449
             .|.:|:..|.:|  ..:::|     :|..::|:|||:..:|:..::..|||:|..|..|.:.:|
plant   304 -VRDVMTLHLREM--GKQLVTDPEKSKDPVEFVQRLLDERDKYDRIINMAFNNDKTFQNALNSSF 365

  Fly   450 KTVVNDTSVFKMELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDV 514
            :..||                      ..::.||.::.:.|..||:.  .|.:..|.:|..|..|
plant   366 EYFVN----------------------LNTRSPEFISLFVDDKLRKG--LKGVGEEDVDLILDKV 406

  Fly   515 LLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIK 578
            :::.:|:..||||.:|:|.||.:||:.|.:...:.|.:::..|: |.|.  .:.::|..||.|:|
plant   407 MMLFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERNLIVKLKTECGY--QFTSKLEGMFTDMK 469

  Fly   579 VSEDLNTQFRTS---ISRHDAINIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGR 640
            .|.|....|..|   :|....:.:::|..|:|. ....:..:||.|:.........:|...|:||
plant   470 TSHDTLLGFYNSHPELSEGPTLVVQVLTTGSWP-TQPTIQCNLPAEVSVLCEKFRSYYLGTHTGR 533

  Fly   641 KLQWYHHMSNGTITFVNNFG---RYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELR 702
            :|.|..:|....|..|  ||   :::|:|:||||.||..:|  ..|::||:.:..|||:|.|:|:
plant   534 RLSWQTNMGTADIKAV--FGKGQKHELNVSTFQMCVLMLFN--NSDRLSYKEIEQATEIPTPDLK 594

  Fly   703 RTLWSLVAFPKIK-KQILLMEPAAISSPKDFAENTMFYINQEFAI----VKNGKSQRRGKLNLIG 762
            |.|.|:..   :| |.:|..||.:    |:.||...|.:|..||.    ||            ||
plant   595 RCLQSMAC---VKGKNVLRKEPMS----KEIAEEDWFVVNDRFASKFYKVK------------IG 640

  Fly   763 RL--QLSTERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMI 825
            .:  |..||..:||..|.:.:.|..:.:.||::|||.|:.:::..:..|:...|:..||.:...|
plant   641 TVVAQKETEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRVLDHNNIIAEVTKQLQTRFLANPTEI 705

  Fly   826 KEQLEWLIENKYMRRDDDDINMFIYVA 852
            |:::|.|||..::.||:.|..::.|:|
plant   706 KKRIESLIERDFLERDNTDRKLYRYLA 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	155/561 (28%)
		Cullin_Nedd8	779..846	CDD:214883	20/66 (30%)
CUL3B	NP_177125.3	Cullin	29..630	CDD:459983	155/561 (28%)
		Cullin_Nedd8	662..724	CDD:463146	19/61 (31%)