Protein Alignment Cul5 and CUL3

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_174005.1
• Gene: CUL3 / 839226
• AraportID: AT1G26830
• Length: 732
• Species: Arabidopsis thaliana
• Alignment Length: 666
• Identity: 182/666 - (27%)
• Similarity: 332/666 - (49%)
• Gaps: 82/666 - (12%)

  Fly   208 TEDSPVRKLMLDSWNKHIFH--DIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAE 270
            |:.:.|..:.|:.|..::.|  .|..||..:.:.:|..||.|:..|..|:..|.:.:::|..:
plant   128 TKKTHVHPMGLNLWRDNVVHFTKIHTRLLNTLLDLVQKERIGEVIDRGLMRNVIKMFMDLGES-- 190

  Fly   271 DKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSIL 335
                :|:|:||..:|.|:.|||:::|.|..:......|:|.::.:|.||..|...||:..|...:
plant   191 ----VYQEDFEKPFLDASSEFYKVESQEFIESCDCGDYLKKSEKRLTEEIERVAHYLDAKSEEKI 251

  Fly   336 TYTLVNVLIVDHLNSII-AECPALIR---DYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMS 396
            |..:...:|.:|:..:: .|...|:.   :.:.|.|..|:.|..||.:|:..       .|.:|:
plant   252 TSVVEKEMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLVT-------VRDVMT 309

  Fly   397 AGLADMLSASEVIT-----QDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDT 456
            :.|.:|  ..:::|     :|..::|:|||:..:|:..::..||.:|..|..|.:.:|:..:|
plant   310 SHLREM--GKQLVTDPEKSKDPVEFVQRLLDERDKYDKIINTAFGNDKTFQNALNSSFEYFIN-- 370

  Fly   457 SVFKMELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYV 521
                                ..::.||.::.:.|..||:.  .|.:|...::..|..|:::.:|:
plant   371 --------------------LNARSPEFISLFVDDKLRKG--LKGITDVDVEVILDKVMMLFRYL 413

  Fly   522 NNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNT 585
            ..||||.:|:|.||.:||:.|.:...:.|..::..|: |.|.  .:.::|..||.|:|.|||...
plant   414 QEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGY--QFTSKLEGMFTDMKTSEDTMR 476

  Fly   586 QFRTS---ISRHDAINIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHH 647
            .|..|   :|....:.:::|..|:|. ....|..:||.|:.........:|...|:||:|.|..:
plant   477 GFYGSHPELSEGPTLIVQVLTTGSWP-TQPAVPCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTN 540

  Fly   648 MSNGTITFVNNFG---RYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLV 709
            |....|..:  ||   :::|:|:||||.||..:|  ..|::||:.:..|||:|..:|:|.|.||.
plant   541 MGTADIKAI--FGKGQKHELNVSTFQMCVLMLFN--NSDRLSYKEIEQATEIPAADLKRCLQSLA 601

  Fly   710 AFPKIK-KQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRL--QLSTERS 771
            .   :| |.::..||.:    ||..|..:|.:|.:|       :.:..|:. ||.:  |..||..
plant   602 C---VKGKNVIKKEPMS----KDIGEEDLFVVNDKF-------TSKFYKVK-IGTVVAQKETEPE 651

  Fly   772 QQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENK 836
            :||..|.:.:.|..:.:.||::|||.||.:::..:..|:...|:..||.:...||:::|.|||..
plant   652 KQETRQRVEEDRKPQIEAAIVRIMKSRKILDHNNIIAEVTKQLQPRFLANPTEIKKRIESLIERD 716

  Fly   837 YMRRDDDDINMFIYVA 852
            ::.||..|..::.|:|
plant   717 FLERDSTDRKLYRYLA 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	149/553 (27%)
		CULLIN	520..655	CDD:214545	42/138 (30%)
		Cullin_Nedd8	779..846	CDD:214883	21/66 (32%)
CUL3	NP_174005.1	Cullin	29..630	CDD:395716	149/554 (27%)
		Cullin_Nedd8	662..721	CDD:402267	18/58 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820