Protein Alignment Cul5 and CUL4

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_568658.1
• Gene: CUL4 / 834663
• AraportID: AT5G46210
• Length: 792
• Species: Arabidopsis thaliana
• Alignment Length: 673
• Identity: 175/673 - (26%)
• Similarity: 317/673 - (47%)
• Gaps: 81/673 - (12%)

  Fly   197 SSSTSTSKKNPTEDSPVRKLM---LDSWNKH--IFHDIKHRLQESAMKIVHAERNGDAYDAQLVV 256
            |.:.:..:|...::..||.|.   |..:.||  :..:::.|..:..:.::..||..:|.:..|:.
plant   184 SIALTLDRKYVIQNPNVRSLWEMGLQLFRKHLSLAPEVEQRTVKGLLSMIEKERLAEAVNRTLLS 248

  Fly   257 GVRESYVNLSSNAEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEV 321
            .:.:.:..|.        ||.|:||..:|:.|.|||..:..:..|::.|..|:|:.:.:|.||..
plant   249 HLLKMFTALG--------IYMESFEKPFLEGTSEFYAAEGMKYMQQSDVPEYLKHVEGRLHEENE 305

  Fly   322 RAKRYLEPSSFSILTYTLVNVLIVDHLNSIIAE-CPALIRDYETERLNLMFRLMDRVMHGVGVEP 385
            |...|::..:...|..|:...|:..|:..::.: ...|:....||.|..|..|..||.   .:|.
plant   306 RCILYIDAVTRKPLITTVERQLLERHILVVLEKGFTTLMDGRRTEDLQRMQTLFSRVN---ALES 367

  Fly   386 MMGDLQRHIMSAGLADMLSASEVITQDSEK---YVERLLELFNKFSDLV-RNAFNDDPRFLTARD 446
            :...|..::...|        :.|..|.||   .|:.||: |....|:: ..:|..:..|.....
plant   368 LRQALSSYVRKTG--------QKIVMDEEKDKDMVQSLLD-FKASLDIIWEESFYKNESFGNTIK 423

  Fly   447 IAFKTVVNDTSVFKMELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARL 511
            .:|:.::|                     ..:::..||:|.:.|..||..  :|..:.|::::.|
plant   424 DSFEHLIN---------------------LRQNRPAELIAKFLDEKLRAG--NKGTSEEELESVL 465

  Fly   512 RDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQ 575
            ..||::.:::..||||..::|..|.:||:||.||..:.|:.::..|: |.|  :.:.|:|..||:
plant   466 EKVLVLFRFIQGKDVFEAFYKKDLAKRLLLGKSASIDAEKSMISKLKTECG--SQFTNKLEGMFK 528

  Fly   576 DIKVSEDLNTQF------RTSISRHDAINIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYK 634
            ||::|:::|..|      ||.:.....:::.:|..|.|..... :.|.||.||..|....:|||.
plant   529 DIELSKEINESFKQSSQARTKLPSGIEMSVHVLTTGYWPTYPP-MDVKLPHELNVYQDIFKEFYL 592

  Fly   635 KKHSGRKLQWYHHMSNGTITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDP 699
            .|:|||:|.|.:.:.:..:....:.|:.:|.|:.||..||..:|...  |:|:|:::.:|.:.|.
plant   593 SKYSGRRLMWQNSLGHCVLKADFSKGKKELAVSLFQAVVLMLFNDAM--KLSFEDIKDSTSIEDK 655

  Fly   700 ELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRL 764
            ||||||.||...   |.::|...|..    :|..:...|..|.|||     ....|.|:|.|...
plant   656 ELRRTLQSLACG---KVRVLQKNPKG----RDVEDGDEFEFNDEFA-----APLYRIKVNAIQMK 708

  Fly   765 QLSTERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQL 829
            :  |........:.:.|.|..:...||::|||.||.:::..|..||...||....|:.  :|:::
plant   709 E--TVEENTSTTERVFQDRQYQIDAAIVRIMKTRKVLSHTLLITELFQQLKFPIKPAD--LKKRI 769

  Fly   830 EWLIENKYMRRDDDDINMFIYVA 852
            |.||:.:|:.|:..:..::.|:|
plant   770 ESLIDREYLEREKSNPQIYNYLA 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	144/563 (26%)
		Cullin_Nedd8	779..846	CDD:214883	21/66 (32%)
CUL4	NP_568658.1	Cullin	96..693	CDD:459983	144/563 (26%)
		Cullin_Nedd8	724..784	CDD:463146	20/61 (33%)