Protein Alignment Cul5 and CUL1

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_001031575.1
• Gene: CUL1 / 825648
• AraportID: AT4G02570
• Length: 738
• Species: Arabidopsis thaliana
• Alignment Length: 664
• Identity: 178/664 - (26%)
• Similarity: 318/664 - (47%)
• Gaps: 75/664 - (11%)

  Fly   212 PVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIY 276
            |:.::.|..:...:::::..:::::.:.:|..||.|:..|..|:..|.:.||.:...   ::|.|
plant   127 PLNEVGLTCFRDLVYNELHSKVKQAVIALVDKEREGEQIDRALLKNVLDIYVEIGMG---QMERY 188

  Fly   277 RENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVN 341
            .|:||...|:.|..:|..|::...||:....||..::..|::|..|...||..||...|...:.:
plant   189 EEDFESFMLQDTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERERVAHYLHSSSEPKLVEKVQH 253

  Fly   342 VLIVDHLNSIIAE----CPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADM 402
            .|:|...:.::.:    |.||:||.:.:.|:.|:||..:::.  |:||:....::|:.:.|.|.:
plant   254 ELLVVFASQLLEKEHSGCRALLRDDKVDDLSRMYRLYHKILR--GLEPVANIFKQHVTAEGNALV 316

  Fly   403 LSASEVITQ--------DSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVF 459
            ..|.:..|.        ..:..:.:::||.:|:...|...|.:...|..|...||:...|.|
plant   317 QQAEDTATNQVANTASVQEQVLIRKVIELHDKYMVYVTECFQNHTLFHKALKEAFEIFCNKT--- 378

  Fly   460 KMELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNK 524
                   :|.         |...||||.:||.:|::.. |::|:.|.|:..|..|:.:|.|:::|
plant   379 -------VAG---------SSSAELLATFCDNILKKGG-SEKLSDEAIEDTLEKVVKLLAYISDK 426

  Fly   525 DVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRT 589
            |:|..:::..|.|||:...||:.:.|..|:..|:: .....:.:::..|..|:.::.:....|..
plant   427 DLFAEFYRKKLARRLLFDRSANDDHERSILTKLKQ-QCGGQFTSKMEGMVTDLTLARENQNSFED 490

  Fly   590 SISRHDAIN------IKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHM 648
            .:..:.|.|      :.:|..|.|. ..:...::||.|:...:...:.||:.|...|||.|.:
plant   491 YLGSNPAANPGIDLTVTVLTTGFWP-SYKSFDINLPSEMIKCVEVFKGFYETKTKHRKLTWIY-- 552

  Fly   649 SNGTITFVNNFGRYD-----LDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSL 708
            |.|| ..:|  |::|     |.|:|:|.|||..:|..  ||:||..:.....|...:|.|.|.||
plant   553 SLGT-CHIN--GKFDQKAIELIVSTYQAAVLLLFNTT--DKLSYTEILAQLNLSHEDLVRLLHSL 612

  Fly   709 VAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQ 773
            ..   .|.:|||.||    :.|..::|..|..|.:|.     ...||.|:.|   ..:...:...
plant   613 SC---AKYKILLKEP----NTKTVSQNDAFEFNSKFT-----DRMRRIKIPL---PPVDERKKVV 662

  Fly   774 EDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYM 838
            ||   :.:.|......||::|||.||.:.:..|..|.::.|..||.|..|.||:::|.||...|:
plant   663 ED---VDKDRRYAIDAAIVRIMKSRKVLGHQQLVSECVEQLSRMFKPDIKAIKKRMEDLITRDYL 724

  Fly   839 RRDDDDINMFIYVA 852
            .||.::.|||.|:|
plant   725 ERDKENPNMFRYLA 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	143/553 (26%)
		CULLIN	520..655	CDD:214545	34/140 (24%)
		Cullin_Nedd8	779..846	CDD:214883	23/66 (35%)
CUL1	NP_001031575.1	Cullin	12..641	CDD:395716	143/554 (26%)
		Cullin_Nedd8	668..729	CDD:402267	23/60 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820