Protein Alignment Cul5 and CUL5

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_003469.2
• Gene: CUL5 / 8065
• HGNCID: 2556
• Length: 780
• Species: Homo sapiens
• Alignment Length: 850
• Identity: 512/850 - (60%)
• Similarity: 630/850 - (74%)
• Gaps: 94/850 - (11%)

  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCLWDEKGAAKIYDCLQQDIVEFIVQAQSQ 77
            ||:.|...|.||||||||::|::::|.|||..||.|||||:||.|||:..|::||:|||.|||::
Human    15 FEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQAQAR 79

  Fly    78 VQAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSASVSASGASTSAAA 142
            |.:.:.:.|||..|||||||||||.:.||.||.|||.:
Human    80 VLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEIT--------------------------- 117

  Fly   143 AAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTSTSKKNP 207
                     ..||.|                                            ::||:.
Human   118 ---------LMGKQG--------------------------------------------SNKKSN 129

  Fly   208 TEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDK 272
            .|||.|||||||:||:.||.:||:|||:||||:|||||.|:|:|:|||:|||||||||.||.|||
Human   130 VEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDK 194

  Fly   273 LEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEP----SSFS 333
            |:|||:|||.|||.:|..|||.::....|:|||..||||||:||:|||.||.||||.    :|..
Human   195 LQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVE 259

  Fly   334 ILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAG 398
            .|....||.|:.....:|:|||..:|:..|||:|:|||.|||:|.:  |:|||:.||:.||:|||
Human   260 ALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPN--GIEPMLKDLEEHIISAG 322

  Fly   399 LADMLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMEL 463
            ||||::|:|.||.|||||||:||.|||:||.||:.||.||||||||||.|:|.||||.::||:||
Human   323 LADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLEL 387

  Fly   464 PTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFM 528
            |......|:| |.||||||||||||||||||:|||||:||||:|:|:|::||||||||.||||||
Human   388 PLKQKGVGLK-TQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFM 451

  Fly   529 RYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISR 593
            ||||.||||||||..|||||.||::|||||||||||||||:|||||||||||||||..|:.....
Human   452 RYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKN 516

  Fly   594 H------DAINIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGT 652
            :      |::||||||||||:|.||:|.||||.||||.||:|||||||.||||||.|:|.||||.
Human   517 NKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGI 581

  Fly   653 ITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQ 717
            |||.|..|:|||:|||||:|||||||||..:|||:|||:|||||||.||||||||||||||:|:|
Human   582 ITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQ 646

  Fly   718 ILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQEDNQSIVQL 782
            :||.|| .::|||||.|.|:|.:||||:::||.|.|:|||:||||||||:|||.::|:|:.||||
Human   647 VLLYEP-QVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQL 710

  Fly   783 RILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINM 847
            ||||||||||:|||:||:::||.||.||::||||||||.|||||||:|||||:||:|||:.|||.
Human   711 RILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINT 775

  Fly   848 FIYVA 852
            |||:|
Human   776 FIYMA 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	431/736 (59%)
		Cullin_Nedd8	779..846	CDD:214883	51/66 (77%)
CUL5	NP_003469.2	Cullin	19..672	CDD:459983	431/736 (59%)
		Cullin_Nedd8	711..772	CDD:463146	46/60 (77%)