DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul5 and Cul5

DIOPT Version :9

Sequence 1:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_082083.3	Gene:	Cul5 / 75717	MGIID:	1922967	Length:	780	Species:	Mus musculus

Alignment Length:	850	Identity:	507/850 - (59%)
Similarity:	629/850 - (74%)	Gaps:	94/850 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCLWDEKGAAKIYDCLQQDIVEFIVQAQSQ 77
            ||:.|.....||||||||::|::::|.|||..||.|||||:||::||:..|::||:|||.|||::
Mouse    15 FEDKWDFMHPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGSSKIHQALKEDILEFIKQAQAR 79

  Fly    78 VQAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSASVSASGASTSAAA 142
            |.:.:.:.|||..|||||||||||.:.||.||.|||.:...|.||
Mouse    80 VLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLGKQSS-------------------- 124

  Fly   143 AAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTSTSKKNP 207
                                                                        :||:.
Mouse   125 ------------------------------------------------------------NKKSN 129

  Fly   208 TEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDK 272
            .|||.|||||||:||:.||.:||:|||:||||:|||||.|:|:|:|||:|||||||||.||.|||
Mouse   130 MEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDK 194

  Fly   273 LEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEP----SSFS 333
            |:|||:|||.|||.:|..|||.::....|:|||..||||||:||:|||.||.||||.    :|..
Mouse   195 LQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVE 259

  Fly   334 ILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAG 398
            .|....||.|:.....:|:|||..:|:..|||:|:|||.|||:|.:  |:|||:.||:.||:|||
Mouse   260 ALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPN--GIEPMLKDLEEHIISAG 322

  Fly   399 LADMLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMEL 463
            ||||::|:|.||.|||||||:||.|||:||.||:.||.||||||||||.|:|.||||.::||:||
Mouse   323 LADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLEL 387

  Fly   464 PTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFM 528
            |......|:| |.||||||||||||||||||:|||||:||||:|:|:|::||||||||.||||||
Mouse   388 PLKQKGVGLK-TQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFM 451

  Fly   529 RYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISR 593
            ||||.||||||||..|||||.||::|||||||||||||||:|||||||||||||||..|:.....
Mouse   452 RYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKN 516

  Fly   594 H------DAINIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGT 652
            :      |::||||||||||:|.||:|.||||.||||.||:|||||||.||||||.|:|.||||.
Mouse   517 NKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGI 581

  Fly   653 ITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQ 717
            |||.|..|:|||:|||||:|||||||||..:|||:|||:|||||||.||||||||||||||:|:|
Mouse   582 ITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQ 646

  Fly   718 ILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQEDNQSIVQL 782
            :||.:| .::|||||.|.|:|.:||:|:::||.|.|:|||:||||||||:|||.::|:|:.||||
Mouse   647 VLLYDP-QVNSPKDFTEGTLFSVNQDFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQL 710

  Fly   783 RILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINM 847
            ||||||||||:|||:||:::||.||.||::||||||||.|||||||:|||||::|:|||:.|||.
Mouse   711 RILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQMEWLIEHRYIRRDEADINT 775

  Fly   848 FIYVA 852
            |||:|
Mouse   776 FIYMA 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	418/719 (58%)
		CULLIN	520..655	CDD:214545	103/140 (74%)
		Cullin_Nedd8	779..846	CDD:214883	50/66 (76%)
Cul5	NP_082083.3	Cullin	19..672	CDD:334305	375/662 (57%)
Cul5	NP_082083.3	Cullin_Nedd8	713..772	CDD:337788	35/58 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848676
Domainoid	1	1.000	729	1.000	Domainoid score	I108
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2597
Inparanoid	1	1.050	887	1.000	Inparanoid score	I395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49236
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0005530
OrthoInspector	1	1.000	-	-		oto93735
orthoMCL	1	0.900	-	-		OOG6_107737
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2468
SonicParanoid	1	1.000	-	-		X3952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800