Protein Alignment Cul5 and cul1

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_001039255.1
• Gene: cul1 / 734121
• XenbaseID: XB-GENE-945766
• Length: 776
• Species: Xenopus tropicalis
• Alignment Length: 654
• Identity: 206/654 - (31%)
• Similarity: 346/654 - (52%)
• Gaps: 50/654 - (7%)

  Fly   213 VRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAED------ 271
            :..|.|.:|...:|..:..::..:.:|::..||||:..:.:|:.||.:|||.|..|.:|
 Frog   159 IYSLALVTWRDCLFKPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGP 223

  Fly   272 KLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILT 336
            .|.:|:|:||..:|..|..||..:|.|..|:|.|..|||.|:::|.||:.|.:.||..|:...|.
 Frog   224 TLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELA 288

  Fly   337 YTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLAD 401
            .....|||..||.....|...|:...:.|.|..|:.|:.|:..|:|....:  |:.||.:.|||.
 Frog   289 RKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKL--LETHIHNQGLAA 351

  Fly   402 MLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTS 466
            :....|....|.:.||:.:|::..|::.||.:|||:|..|:.|.|.|....:|:.:|.||
 Frog   352 IEKCGEAAQNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKM----- 411

  Fly   467 IANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYH 531
                    ....||.|||||.|||.||:::  ||.....:::..|..|::|.||:.:||||.:::
 Frog   412 --------AQSSSKSPELLARYCDSLLKKS--SKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFY 466

  Fly   532 KVHLTRRLILGTSADSEKEEDIVEWLREV-GMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHD 595
            ...|.:||:...||..:.|..::..|::. |.  :|.::|.||||||.||:|||.||:..::..:
 Frog   467 AKMLAKRLVHQNSASDDAEASMISKLKQACGF--EYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE 529

  Fly   596 AI----NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFV 656
            .:    :|::|::|:|. ..:..:.:||.|||........||..:||||||.|.:.:|.|.:. .
 Frog   530 PLDLDFSIQVLSSGSWP-FQQFCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELV-T 592

  Fly   657 NNF-GRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILL 720
            |.| .||.|..:|||||:|..:|  ..|..:.:.|..:|::....|.:.|..|     :|.::|:
 Frog   593 NCFKNRYTLQASTFQMAILLQYN--TEDAYTVQQLTDSTQIKMDILVQVLQIL-----LKSKLLV 650

  Fly   721 MEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQED--NQSIVQLR 783
            :|        |...|......:...::|.....:..||.:...:.:.||:.|:::  :::|.:.|
 Frog   651 LE--------DENANVDDVDLKPDILIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDR 707

  Fly   784 ILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMF 848
            .|..|.||::|||:||.:.:..|.||::..|.:.|.|...:||:.::.|||.:|:.|.|.:.:.:
 Frog   708 KLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTY 772

  Fly   849 IYVA 852
            .|:|
 Frog   773 SYLA 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	173/541 (32%)
		CULLIN	520..655	CDD:214545	48/139 (35%)
		Cullin_Nedd8	779..846	CDD:214883	25/66 (38%)
cul1	NP_001039255.1	Cullin	21..662	CDD:366357	173/538 (32%)
		Cullin_Nedd8	703..770	CDD:214883	25/66 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920