DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul5 and Cul4b

DIOPT Version :9

Sequence 1:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001103612.1	Gene:	Cul4b / 72584	MGIID:	1919834	Length:	970	Species:	Mus musculus

Alignment Length:	825	Identity:	213/825 - (25%)
Similarity:	366/825 - (44%)	Gaps:	144/825 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 QLEQSPQVKPSSSGSSSSASV-SASG-ASTSAAAAAAATSCSGQAGK-------------SGAST 160
            |.:|..|:|..|...||.||| .|:| |.:|.|.::.|.|..|.|.|             ...:.
Mouse   207 QQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTD 271

  Fly   161 SAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTSTSK--KNPTED------SPVRKLM 217
            ........:..|...|||...:......|.....|...|.:..|  :...||      ...|:..
Mouse   272 ETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDS 336

  Fly   218 LDS----------WNKH-----------IFHDIKHRLQESAMK---------------------- 239
            |||          |..|           :|.|..:.||.|.:.
Mouse   337 LDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQT 401

  Fly   240 --------IVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENFEMAYLKATVEFYRLKS 296
                    ::..||||:|.|..|:    .|.:::.|:    |:||:::||..:|:.|...|..:.
Mouse   402 KTIDGILLLIERERNGEAIDRSLL----RSLLSMLSD----LQIYQDSFEQQFLQETNRLYAAEG 458

  Fly   297 AEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIVDHLNSIIAE-CPALIR 360
            .:..||..|..|:.:.:.:|.||..|...||:.::...|..::...|:.:||.:|:.: ..:|:.
Mouse   459 QKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLD 523

  Fly   361 DYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEVITQDSEK-YVERLLELF 424
            :...:.|:|:::|..||..||.|  ::.....:|.:.|      ::.||..:.:| .|:.||:..
Mouse   524 ENRIQDLSLLYQLFSRVRGGVQV--LLQQWIEYIKAFG------STIVINPEKDKTMVQELLDFK 580

  Fly   425 NKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVKYTAPESKCPELLANYC 489
            :|...::...|..:.:|:.|...||:|.:|..                     .:|..||:|.|.
Mouse   581 DKVDHIIDTCFLKNEKFINAMKEAFETFINKR---------------------PNKPAELIAKYV 624

  Fly   490 DMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIV 554
            |..||..  :|..|.|:::..|..::::.:::..||||..::|..|.:||::|.||..:.|:.::
Mouse   625 DSKLRAG--NKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSML 687

  Fly   555 EWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHDA-----INIKILNAGAWARCSER 613
            ..|: |.|  |.:.::|..||:|:::|:|:..||:..:...:.     :.:.||..|.|.....
Mouse   688 SKLKHECG--AAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVP- 749

  Fly   614 VSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRYDLDVTTFQMAVLFAWN 678
            :.|.||.|:.......:.||..|||||||||...:.:..:......|:.:|.|:.||..||..:|
Mouse   750 MEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFN 814

  Fly   679 QRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQE 743
              :.::.|.|.::.||.:.|.||||||.||...   |.::|...|..    ||..:...|..|.:
Mouse   815 --EGEEFSLEEIKHATGIEDGELRRTLQSLACG---KARVLAKNPKG----KDIEDGDKFICNDD 870

  Fly   744 FAIVKNGKSQRRGKLNLIGRLQL-STERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQ 807
            |.     ....|.|:|   ::|: .|...|....:.:.|.|..:...||::|||:||.:::..|.
Mouse   871 FK-----HKLFRIKIN---QIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLV 927

  Fly   808 GELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMFIYVA 852
            .|:.:.||....|:.  :|:::|.||:..||.||.::.|.:.|:|
Mouse   928 SEVYNQLKFPVKPAD--LKKRIESLIDRDYMERDKENPNQYNYIA 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	181/713 (25%)
		CULLIN	520..655	CDD:214545	43/140 (31%)
		Cullin_Nedd8	779..846	CDD:214883	22/66 (33%)
Cul4b	NP_001103612.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..157
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q13620	112..115
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..211		1/3 (33%)
		Cullin	275..870	CDD:279260	161/645 (25%)
		CULLIN	653..793	CDD:214545	43/142 (30%)
		Cullin_Nedd8	899..964	CDD:214883	22/66 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820