DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul5 and Cul2

DIOPT Version :9

Sequence 1:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001347758.1	Gene:	Cul2 / 71745	MGIID:	1918995	Length:	745	Species:	Mus musculus

Alignment Length:	860	Identity:	221/860 - (25%)
Similarity:	391/860 - (45%)	Gaps:	144/860 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCL-WDEKGAAKIYDCLQQDIVEFIVQAQS 76
            |:|.|......:..::..:.|.:..|.|.|..::.:|: :.|....::|       .|..:..:|
Mouse    10 FDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLY-------AETKIFLES 67

  Fly    77 QV-----QAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSASVSASGA 136
            .|     :....|:.:|..|...|.::...::|:...:|.|
Mouse    68 HVRHLYKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYL------------------------ 108

  Fly   137 STSAAAAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTS 201
            :|........|....|.|..|...:
Mouse   109 NTQYIKKNKLTEADIQYGYGGVDMN---------------------------------------- 133

  Fly   202 TSKKNPTEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLS 266
                .|..:  :.:|.||.|.|.:...:::.|....::.:..:|.|:..:.:::.||..|:|::.
Mouse   134 ----EPLME--IGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVE 192

  Fly   267 S-NAEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPS 330
            . ..:..|:.|:..|...:|..|.|:|:.:::...||:....||:....:|::||:|.::||.||
Mouse   193 QYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPS 257

  Fly   331 SFSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIM 395
            |::.:.:.....::.|||..:.:||.::|:......:..|:.|:..|  ..|:..|:.:||:||.
Mouse   258 SYTKVIHECQQRMVADHLQFLHSECHSIIQQERKNDMANMYVLLRAV--SSGLPHMIEELQKHIH 320

  Fly   396 SAGLADMLSASEVITQD--SEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSV 458
            ..|    |.|:..:||:  ...:||.:||:..||..|:....|.|..|::|.|.|..:|||
Mouse   321 DEG----LRATSNLTQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVN---- 377

  Fly   459 FKMELPTSIANRGVKYTAPESKC--PELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYV 521
                           |..|:|.|  |||||.|||.||:::  :|.:|..:::.:|...:.|.||:
Mouse   378 ---------------YREPKSVCKAPELLAKYCDNLLKKS--AKGMTENEVEDKLTSFITVFKYI 425

  Fly   522 NNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQ 586
            ::||||.:::...|.:|||.|.|...:.||.::..|:: ....::.::|.||:.|:.||.|||.:
Mouse   426 DDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQ-ACGYEFTSKLHRMYTDMSVSADLNNK 489

  Fly   587 FRTSISRHDAI-------NIKILNAGAWARCSERVSV-SLPIELEDYIPDVEEFYKKKHSGRKLQ 643
            |...|...|.:       .|.:|.||||.......|. ::|.|||..:...|.||.:..|||||.
Mouse   490 FNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLT 554

  Fly   644 WYHHMSNGTITFVNNFGR-YDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWS 707
            |.|::..|.:. :|..|: |...|||:|||||.|:|  ..:.:||:.|:.:|::.:.||.:|:.|
Mouse   555 WLHYLCTGEVK-MNYLGKPYVAMVTTYQMAVLLAFN--NSETVSYKELQDSTQMNEKELTKTIKS 616

  Fly   708 LVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQ 772
            |:....|...         |..:|....:.|.:|..|       |.:|.|..:...:|..|.:..
Mouse   617 LLDVKMINHD---------SEKEDIDAESSFSLNMSF-------SSKRTKFKITTSMQKDTPQEL 665

  Fly   773 QEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKY 837
            ::...::.:.|.:..|.||::|||.||.:.:.||..|:|...:..|.||..|||:.:|.||:.:|
Mouse   666 EQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQY 730

  Fly   838 MRRDDDDINMFIYVA 852
            :.|.....:.:.|||
Mouse   731 IERSQASADEYSYVA 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	185/729 (25%)
		CULLIN	520..655	CDD:214545	48/142 (34%)
		Cullin_Nedd8	779..846	CDD:214883	24/66 (36%)
Cul2	NP_001347758.1	Cullin	14..644	CDD:366357	186/746 (25%)
Cul2	NP_001347758.1	Cullin_Nedd8	677..735	CDD:371133	23/57 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820