Protein Alignment Cul5 and Cul5

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: XP_006243152.1
• Gene: Cul5 / 64624
• RGDID: 621742
• Length: 828
• Species: Rattus norvegicus
• Alignment Length: 846
• Identity: 495/846 - (58%)
• Similarity: 612/846 - (72%)
• Gaps: 113/846 - (13%)

  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCLWDEKGAAKIYDCLQQDIVEFIVQAQSQ 77
            ||:.|...|.||||||||::|::::|.|||..||.|||||:||::||:..|::||:|||.|||::
  Rat    90 FEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGSSKIHQALKEDILEFIKQAQAR 154

  Fly    78 VQAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSASVSASGASTSAAA 142
            |.:.:.:.|||..|||||||||||.:.||.||.|||.:...|.||
  Rat   155 VLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLGKQSS-------------------- 199

  Fly   143 AAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTSTSKKNP 207
                                                                        :||:.
  Rat   200 ------------------------------------------------------------NKKSN 204

  Fly   208 TEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDK 272
            .|||.|||||||:||:.||.:||:|||:||||:|||||.|:|:|:|||:|||||||||.||.|||
  Rat   205 MEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDK 269

  Fly   273 LEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTY 337
            |:|||:|||.|||.:|..|||.::....|:|||..||||                       |..
  Rat   270 LQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKY-----------------------LME 311

  Fly   338 TLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADM 402
            ..||.|:.....:|:|||..:|:..|||:|:|||.|||:|..  |:|||:.||:.||:|||||||
  Rat   312 CCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPG--GIEPMLKDLEEHIISAGLADM 374

  Fly   403 LSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSI 467
            ::|:|.||.|||||||:||.|||:||.||:.||.||||||||||.|:|.||||.::||:|||...
  Rat   375 VAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQ 439

  Fly   468 ANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHK 532
            ...|:| |.||||||||||||||||||:|||||:||||:|:|:|::||||||||.||||||||||
  Rat   440 KGVGLK-TQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHK 503

  Fly   533 VHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRH--- 594
            .||||||||..|||||.||::|||||||||||||||:|||||||||||||||..|:.....:
  Rat   504 AHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLA 568

  Fly   595 ---DAINIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFV 656
               |::||||||||||:|.||:|.||||.||||.||:|||||||.||||||.|:|.||||.|||.
  Rat   569 LPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFK 633

  Fly   657 NNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILLM 721
            |..|:|||:|||||:|||||||||..:|||:|||:|||||||.||||||||||||||:|:|:||.
  Rat   634 NEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLY 698

  Fly   722 EPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQEDNQSIVQLRILR 786
            :| .::|||||.|.|:|.:||:|:::||.|.|:|||:||||||||:|||.::|:|:.||||||||
  Rat   699 DP-QVNSPKDFTEGTLFSVNQDFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILR 762

  Fly   787 TQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMFIYV 851
            ||||||:|||:||:::||.||.||::||||||||.|||||||:|||||:||:|||:.|||.|||:
  Rat   763 TQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDEADINTFIYM 827

  Fly   852 A 852
            |
  Rat   828 A 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	404/715 (57%)
		CULLIN	520..655	CDD:214545	103/140 (74%)
		Cullin_Nedd8	779..846	CDD:214883	51/66 (77%)
Cul5	XP_006243152.1	Cullin	95..719	CDD:279260	342/629 (54%)
		CULLIN	491..634	CDD:214545	105/142 (74%)
		Cullin_Nedd8	761..820	CDD:287520	41/58 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352260
Domainoid	1	1.000	727	1.000	Domainoid score	I104
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2597
Inparanoid	1	1.050	888	1.000	Inparanoid score	I374
OMA	1	1.010	-	-		QHG49236
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0005530
OrthoInspector	1	1.000	-	-		oto97278
orthoMCL	1	0.900	-	-		OOG6_107737
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3952
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770