Protein Alignment Cul5 and cul4b

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_001116316.1
• Gene: cul4b / 560313
• ZFINID: ZDB-GENE-041008-208
• Length: 864
• Species: Danio rerio
• Alignment Length: 646
• Identity: 179/646 - (27%)
• Similarity: 322/646 - (49%)
• Gaps: 72/646 - (11%)

  Fly   218 LDSWNKHIFHDIK--HRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENF 280
            |:.:..:|..|:|  .:..:..:.::..||:|:|.|..|:    .|.:::.|:    |:||:::|
Zfish   280 LELFRFYIISDLKVQSKTIDGILLLIERERSGEAVDRSLL----RSLLSMLSD----LQIYQDSF 336

  Fly   281 EMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIV 345
            |..:|:.|...|..:.....||..|..|:.:.:.:|.||..|...||:.|:...|..|:...|:.
Zfish   337 EQRFLEETNRLYAAEGQRLMQEREVPEYLHHVNKRLEEEADRVITYLDQSTQKSLIATVEKQLLG 401

  Fly   346 DHLNSIIAE-CPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEVI 409
            :||.:|:.: ...|:.:...:.|:|:::|..||..||.|  ::.....:|.:.|      ::.||
Zfish   402 EHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQV--LLQHWIEYIKAFG------STIVI 458

  Fly   410 TQDSEK-YVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVK 473
            ..:.:| .|:.||:..:|...::...|..:.:|:.....||:|.:|..
Zfish   459 NPEKDKTMVQELLDFKDKVDHIIDVCFMKNEKFVNGMKEAFETFINKR----------------- 506

  Fly   474 YTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRR 538
                .:|..||:|.|.|..||..  :|..|.|:::..|..::::.:::..||||..::|..|.:|
Zfish   507 ----PNKPAELIAKYVDSKLRAG--NKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKR 565

  Fly   539 LILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFR-----TSISRHDAI 597
            |::|.||..:.|:.::..|: |.|  |.:.::|..||:|:::|:|:..||:     .:|..:..:
Zfish   566 LLVGKSASVDAEKSMLSKLKHECG--AAFTSKLEGMFKDMELSKDIMVQFKQHMQCQNIPGNIEL 628

  Fly   598 NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRY 662
            .:.||..|.|..... :.|.||.|:.......:.||..|||||||||...:.:..:......|:.
Zfish   629 TVNILTMGYWPTYVP-MEVHLPAEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKK 692

  Fly   663 DLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILLMEPAAIS 727
            :|.|:.||..||..:|  :.::.|.|:::|||.:.|.||||||.||...   |.::|...|.:
Zfish   693 ELQVSLFQTLVLLMFN--EGEEFSLEDIKLATGIEDSELRRTLQSLACG---KARVLTKIPKS-- 750

  Fly   728 SPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQL-STERSQQEDNQSIVQLRILRTQEAI 791
              ||..:...|..|.:|.     ....|.|:|   ::|: .|...|....:.:.|.|..:...||
Zfish   751 --KDVEDGDKFSCNDDFK-----HKLFRIKIN---QIQMKETVEEQASTTERVFQDRQYQIDAAI 805

  Fly   792 IKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMFIYVA 852
            ::|||:||.:::..|..|:.:.||....|:.  :|:::|.||:..||.||.::.|.:.|||
Zfish   806 VRIMKMRKTLSHNLLVSEVYNQLKFPVKPAD--LKKRIESLIDRDYMERDKENPNQYNYVA 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	146/534 (27%)
		CULLIN	520..655	CDD:214545	44/140 (31%)
		Cullin_Nedd8	779..846	CDD:214883	22/66 (33%)
cul4b	NP_001116316.1	Cullin	169..764	CDD:279260	146/534 (27%)
		CULLIN	547..687	CDD:214545	44/142 (31%)
		Cullin_Nedd8	793..858	CDD:214883	22/66 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850