DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul5 and cul3

DIOPT Version :9

Sequence 1:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001015975.2	Gene:	cul3 / 548729	XenbaseID:	XB-GENE-974982	Length:	768	Species:	Xenopus tropicalis

Alignment Length:	673	Identity:	174/673 - (25%)
Similarity:	323/673 - (47%)	Gaps:	95/673 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 IFHD-------IKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENFEM 282
            ||.|       |:..|:::.:.::..||.|:..|..   .:|.:...|.....:...:|.|:||.
Frog   146 IFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRG---AIRNACQMLMILGLEGRSVYEEDFEA 207

  Fly   283 AYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIVDH 347
            .:|:.:.||::::|.:...||....|:|..::::.||..|....|:.|:...:...:...||..|
Frog   208 PFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKH 272

  Fly   348 LNSII----AECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEV 408
            :.:|:    :....::::.:||.|..|::|..||.:  |::.|...:..::...|.|       :
Frog   273 MKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPN--GLKTMCECMSLYLREQGKA-------L 328

  Fly   409 ITQDSE-----KYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIA 468
            ::::.|     .|::.||:|.::|...::.:|::|..|.       :|:..|...| :.|
Frog   329 VSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFSNDRLFK-------QTIAGDFEYF-LNL----- 380

  Fly   469 NRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKV 533
                     .|:.||.|:.:.|..|::.  .|.||.:::::.|...:::.:::..||||.||:|.
Frog   381 ---------NSRSPEYLSLFIDDKLKKG--VKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQ 434

  Fly   534 HLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFR-----TSIS 592
            ||.|||:...|...:.|::::..|: |.|  ..:.::|..||:|:.:|.....:||     |.:|
Frog   435 HLARRLLTNKSVSDDSEKNMISKLKTECG--CQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVS 497

  Fly   593 RHDA-INIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTI--T 654
            .... :.:::|..|.|...|.....::|............||..|||||:|...|||.:..:  |
Frog   498 LGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNAT 562

  Fly   655 FV--------------------NNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDP 699
            |.                    :|..::.|.|:||||.:|..:|.|  :|.::|.::..|::|:.
Frog   563 FYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNR--EKYTFEEIQQETDIPER 625

  Fly   700 ELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRL 764
            ||.|.|.|| |..|..:::|..||.:    |:.....||.:|.:|.     ....|.|:..:...
Frog   626 ELVRALQSL-ACGKPTQRVLTKEPKS----KEIESGHMFTVNDQFT-----SKLHRVKIQTVAAK 680

  Fly   765 QLSTERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQL 829
            |..::..::|..|.:...|....:.||::|||.||:|.:..|..|:...||..||||..:||:::
Frog   681 QGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRI 745

  Fly   830 EWLIENKYMRRDDDDINMFIYVA 852
            |.|||.:|:.|..:|..::.|||
Frog   746 EGLIEREYLARTPEDRKVYTYVA 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	139/562 (25%)
		CULLIN	520..655	CDD:214545	42/143 (29%)
		Cullin_Nedd8	779..846	CDD:214883	26/66 (39%)
cul3	NP_001015975.2	Cullin	34..665	CDD:366357	139/563 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..698		3/20 (15%)
		Cullin_Nedd8	695..762	CDD:214883	26/66 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920