Protein Alignment Cul5 and cul4a

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_001015893.1
• Gene: cul4a / 548647
• XenbaseID: XB-GENE-1014775
• Length: 753
• Species: Xenopus tropicalis
• Alignment Length: 646
• Identity: 170/646 - (26%)
• Similarity: 311/646 - (48%)
• Gaps: 72/646 - (11%)

  Fly   218 LDSWNKHIFHD--IKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENF 280
            |:.:..|:..|  ::.:..:..:|::..||:|:|.|..|:    .|.:.:.|:    |::|:|:|
 Frog   169 LELFRCHVVSDRMVQIKTIDGILKLIEQERSGEAVDRSLL----RSLLGMLSD----LQVYKESF 225

  Fly   281 EMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIV 345
            |..:|:.|...|..:.....||..|..|:.:.:.:|.||..|...||:..:...|...:...|:.
 Frog   226 ETKFLEETNCLYAAEGQRLMQEREVPEYLHHVNRRLEEEVDRVITYLDHGTHKPLIACVEKQLLG 290

  Fly   346 DHLNSIIAE-CPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEVI 409
            :||.:|:.: ...::.:.....|.||::|..||..|..:  ::.....:|.:.|      :..||
 Frog   291 EHLTAILQKGLKNMLDENRDPELTLMYQLFSRVKGGQII--LLQHWGEYIKNFG------SGLVI 347

  Fly   410 TQDSEK-YVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVK 473
            ..:.:| .|:.||:..:....::...|..:.:|:.....:|:|.:|..:
 Frog   348 NPEKDKDMVQELLDFKDNVDHIIDVCFQKNEKFVNTMKESFETFINRRA---------------- 396

  Fly   474 YTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRR 538
                 :|..||:|.|.|..||..  :|..|.|:::..|..::::.::::.||||..::|..|.:|
 Frog   397 -----NKPAELIAKYVDSKLRSG--NKEATDEELERLLDKIMIIFRFIHGKDVFEAFYKKDLAKR 454

  Fly   539 LILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHD-----AI 597
            |::|.||..:.|:.::..|: |.|  |.:.::|..||:|:::|:|:..||:..:..|.     .:
 Frog   455 LLVGKSASVDSEKSMLSKLKHECG--AAFTSKLEGMFKDMELSKDVMVQFKQHMQNHSDPGNIDL 517

  Fly   598 NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRY 662
            .:.||..|.|...:. |.|.||.|:.......:.||..|||||:|||...:.:..:.......:.
 Frog   518 TVNILTMGYWPTYTP-VDVHLPAEMVKLQEIFKAFYLGKHSGRRLQWQSTLGHAVLKADFKEEKK 581

  Fly   663 DLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILLMEPAAIS 727
            :|.|:.||..||..:|  :.|:..:|.:::.|.:.|.||||||.||...   |.::|...|.:
 Frog   582 ELQVSLFQTLVLLLFN--KGDEFGFEEIKITTGIEDNELRRTLQSLACG---KARVLNKSPKS-- 639

  Fly   728 SPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQL-STERSQQEDNQSIVQLRILRTQEAI 791
              ||..:...|..|.:|.     ....|.|:|   ::|: .|...|....:.:.|.|..:...||
 Frog   640 --KDVEDGDRFCFNADFK-----HKLYRIKIN---QIQMKETVEEQVNTTERVFQDRQYQIDAAI 694

  Fly   792 IKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMFIYVA 852
            ::|||:||.:.:..|..||.:.||....|..  :|:::|.||:..||.||.|:...:.|:|
 Frog   695 VRIMKMRKTLTHNLLVSELYNQLKFPVKPGD--LKKRIESLIDRDYMERDKDNAKQYHYLA 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	137/535 (26%)
		Cullin_Nedd8	779..846	CDD:214883	24/66 (36%)
cul4a	NP_001015893.1	Cullin	57..654	CDD:459983	137/535 (26%)
		Cullin_Nedd8	685..745	CDD:463146	22/61 (36%)