Protein Alignment Cul5 and mr

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_611862.1
• Gene: mr / 45906
• FlyBaseID: FBgn0002791
• Length: 802
• Species: Drosophila melanogaster
• Alignment Length: 827
• Identity: 156/827 - (18%)
• Similarity: 276/827 - (33%)
• Gaps: 282/827 - (34%)

  Fly    13 FEEVWPDKRRIVLKL-----LRQDTVSQREWQDLFFGVHFVCLWDEKGAAKIYDC-LQQDIVEFI 71
            |:.:|.|..||...|     :..|.|.:..:|::  ..|.:.|......|.:.|. :|..|...:
  Fly     4 FDALWADVLRIFPVLGGANAVSNDPVEENVFQNV--RQHLMVLGSIDTFAAVVDLEIQSTIRNVL 66

  Fly    72 VQ----------AQSQVQAQRGEQALLATYIVEWRKFFTQ----SNYLPLPFRQLEQSPQVKPSS 122
            |.          ..|::|....:|||....:.:....|||    .|.|...|:.|   .||||
  Fly    67 VPKFWKHIHDGLVSSKLQGWINDQALAIEALPDKNGLFTQFIDAINELHDSFQSL---MQVKP-- 126

  Fly   123 SGSSSSASVSASGASTSAAAAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAA 187
                  ..:...||.|...|...
  Fly   127 ------RLIQLVGAETKPTAKTV------------------------------------------ 143

  Fly   188 AAASGSGSSSSSTSTSKKNPTEDSPVRKLMLDSWNKHIFHD-------------------IKHRL 233
                                       |||.:...|:...|                   :..:|
  Fly   144 ---------------------------KLMQEEGIKNCLRDCLLAQLPPNFSVVVGAFYWVHFKL 181

  Fly   234 QESAMKIVHAERNGDAYDAQLVVGVR--------ESYVNLSSNAEDKLEIYRENFEMAYL----- 285
            ...|..:.....:.|.:|..|.||..        :...::.:....||      |||..:
  Fly   182 FTKASNLALTTVDSDVFDELLCVGCNFEAEQCCCQRLTDMVNKTNMKL------FEMNLIDRLTG 240

  Fly   286 KATVEFYRLKSAEQQQEN--GVL--AYMKYADSKLRE----------EEVRAKRYLEP------- 329
            .|.....:||..|...:.  |:.  :::|..::.|.:          .|.::|..:..
  Fly   241 SALTALIKLKIKEHISDTCMGIFDRSHLKQLETWLSDVIMSWLTNIFTEWKSKDSISDIEVPESV 305

  Fly   330 SSFSI-LTYTLVNV-----------LIVDHLNSIIAECPAL-----------IRDYETERLNLMF 371
            .||.: |||.:...           :|:|:.:||    ||:           :|.|.||  :|..
  Fly   306 KSFKVKLTYFMYETFAQSVIGQFFSIIIDYPDSI----PAIDDLKICMEKIDMRVYLTE--SLRN 364

  Fly   372 RLMDRVMHGVGVEPMMGDLQ----------RHIMSAGLADMLSASEVITQDSEKYVERLLELFNK 426
            .|..|::| .||..|  |:.          ||:.|.|:     ..|::|...:.|:       .|
  Fly   365 SLEARILH-PGVNTM--DILTGYVAAIKAIRHLDSTGV-----ILEMVTAPIKDYL-------RK 414

  Fly   427 FSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVK-YTAPESK--CPELLANY 488
            .:|.||       |.:|.              ...|.||.::....| .|..|.|  ..:..:|:
  Fly   415 RNDTVR-------RVVTG--------------LTEEGPTDLSEELAKGETIKECKDSGTDEFSNW 458

  Fly   489 ---------CDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTS 544
                     .|..:.:...|:::.|..|      :.:|:....:|::||..::..:..||:....
  Fly   459 ENWQPDPFGIDASIMQYNSSRKMRSADI------ISMVVDIYGSKELFMTEYRNLMADRLLAQLD 517

  Fly   545 ADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHD----AINIKILNAG 605
            .:||||...:|.|: :......::....|.:|:..|:.:|....:...|.:    .|:..|::|.
  Fly   518 FNSEKEIRNLELLK-IRFGESLLHSCEVMLKDVTDSKRINAHIHSDGDRTENQLFDISSLIVSAQ 581

  Fly   606 AWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRYDLDV---- 666
            .|...::. |:.||.|:|:......:.|:.....|.|.|      .|:|     ||.::::
  Fly   582 FWPSFNKE-SLQLPEEIENEFKKYTKAYEAYKGNRTLNW------RTVT-----GRVNIEIEIGD 634

  Fly   667 TTFQMAV-----LFAWNQRQHDKISYENLRLATELPDPELRRTL--W 706
            .|.:|.|     :..::.:..::.:.|:|...|::|...|||.|  |
  Fly   635 RTMEMVVSPILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRLSFW 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	155/823 (19%)
		Cullin_Nedd8	779..846	CDD:214883
mr	NP_611862.1	CULLIN	494..632	CDD:214545	33/150 (22%)
		ANAPC2	741..800	CDD:462556