Protein Alignment Cul5 and cul1b

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_998660.1
• Gene: cul1b / 406816
• ZFINID: ZDB-GENE-040426-2887
• Length: 774
• Species: Danio rerio
• Alignment Length: 655
• Identity: 211/655 - (32%)
• Similarity: 351/655 - (53%)
• Gaps: 52/655 - (7%)

  Fly   213 VRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAED------ 271
            :..|.|.:|.:.:|..:..::..:.:|:|..||||:..:.:||.||.:|||.|..|.:|
Zfish   157 IYSLALATWRECLFRPLNKQVTNAVLKLVEKERNGETINTRLVSGVVQSYVELGLNEDDAFVKGP 221

  Fly   272 KLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILT 336
            .|.:|:|.||..:|..|..||..:|.|..|:|.|..|||.|:::|.||:.|.:.||..|:...|.
Zfish   222 TLSVYKEYFEAQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELA 286

  Fly   337 YTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLAD 401
            .....|||..||.....|...|:...:.|.|..|:.|:.|:..|:|....:  |:.||.:.|||.
Zfish   287 RKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRITDGLGELKKL--LESHIHNQGLAA 349

  Fly   402 MLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTS 466
            :....:....|.:.||:..|::..|::.||.:|||:|..|:.|.|.|....:|:.:|.:|
Zfish   350 IEKCGDSALNDPKMYVQTTLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTRM----- 409

  Fly   467 IANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYH 531
                    ....||.|||||.|||.||:::  ||.....:::..|..|::|.||:.:||||.:::
Zfish   410 --------AQSSSKSPELLARYCDSLLKKS--SKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFY 464

  Fly   532 KVHLTRRLILGTSADSEKEEDIVEWLREV-GMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHD 595
            ...|.:||:...||..:.|..::..|::. |.  :|.::|.||||||.||:|||.||:..:|..:
Zfish   465 AKMLAKRLVHQNSASDDAEASMISKLKQACGF--EYTSKLQRMFQDIGVSKDLNEQFKKHLSNSE 527

  Fly   596 AI----NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFV 656
            .:    :|::|::|:|. ..:..:.:||.|||........||..:||||||.|.:|:|.|.:. .
Zfish   528 PLDLDFSIQVLSSGSWP-FQQSCTFALPSELERSYQRFTAFYGSRHSGRKLTWLYHLSKGELV-T 590

  Fly   657 NNF-GRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILL 720
            |.| .||.|..:|||||:|..:|  ..:..|.:.|..:|::....|.:.|..|     :|.::|:
Zfish   591 NCFKNRYTLQASTFQMAILLQFN--TENCYSVQQLADSTQIKTDILVQVLQIL-----LKSKLLV 648

  Fly   721 MEPA-AISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQED--NQSIVQL 782
            :|.. |.....||..:|:..:   |...||.|.    ::|:  .:.:.||:.|:::  :::|.:.
Zfish   649 LEDENANIDEMDFKPDTLIKL---FLGYKNKKL----RVNI--NVPMKTEQKQEQETTHKNIEED 704

  Fly   783 RILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINM 847
            |.|..|.||::|||:||.:.:..|..|:::.|.:.|.|...:||:.::.|||.:|:.|.|.:.:.
Zfish   705 RKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDT 769

  Fly   848 FIYVA 852
            :.|:|
Zfish   770 YSYLA 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	177/543 (33%)
		Cullin_Nedd8	779..846	CDD:214883	24/66 (36%)
cul1b	NP_998660.1	Cullin	21..660	CDD:459983	174/530 (33%)
		Cullin_Nedd8	704..766	CDD:463146	23/61 (38%)