DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul5 and cul4a

DIOPT Version :9

Sequence 1:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_957321.1	Gene:	cul4a / 394002	ZFINID:	ZDB-GENE-040426-1357	Length:	635	Species:	Danio rerio

Alignment Length:	500	Identity:	134/500 - (26%)
Similarity:	246/500 - (49%)	Gaps:	52/500 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 LDSWNKHIFHD--IKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENF 280
            |:.:..||..|  ::.|..:..::.|..||:|:..|..|:    .|.:.:.|:    |::|:::|
Zfish   160 LELFRTHIVSDAAVQSRTVQGILEQVERERSGETVDRSLL----RSLLGMLSD----LQVYKDSF 216

  Fly   281 EMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIV 345
            |..:|..|...|..:.....||..|..|:.:...:|.||..|...||:.|:...|..|:...|:.
Zfish   217 EQRFLSETTRLYAAEGQRLMQERDVPEYLHHVARRLEEENDRVISYLDQSTQKPLIATVEKQLLG 281

  Fly   346 DHLNSIIAE-CPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEVI 409
            :|:.:|:.: ...|:.:.....|.|::.|..:|..  |:..::...:.:|.|.| |:.:.:.|
Zfish   282 EHMTTILQKGLRTLLDENRVCELTLLYELFSKVKG--GLTALLQSWREYIKSVG-AETVCSPE-- 341

  Fly   410 TQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVKY 474
             :|.| .|:.||:..::...:.::.|..:..|:.|...||:..:|..
Zfish   342 -RDRE-MVQELLDFKDQMDSVTQSCFQRNESFINAMKEAFENFINQR------------------ 386

  Fly   475 TAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRL 539
               .:|..||:|.|.|..||..  :|..|.|:::..|..::::.::::.||||..::|..|.:||
Zfish   387 ---PNKPAELIAKYVDSKLRAG--NKEATEEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRL 446

  Fly   540 ILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHD-----AIN 598
            ::|.||..:.|:.::..|: |.|  |.:.::|..||:|:::|:|:..||:..:....     .:.
Zfish   447 LVGKSASVDAEKSMLSKLKHECG--AAFTSKLEGMFKDMELSKDIMIQFKQYMQNQTEPSNIELT 509

  Fly   599 IKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRYD 663
            :.||..|.|...:. :.|.||.|:.......:.||..|||||||||...:.:..:......|:.:
Zfish   510 VNILTMGYWPSYTP-MDVHLPAEMVKLQEVFKLFYLGKHSGRKLQWQPTLGHAVLKTEFKEGKKE 573

  Fly   664 LDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSL 708
            |.|:.||..||..:|  :.|:.|.|.:|:||.:.:.||:|||.||
Zfish   574 LQVSLFQTLVLLMFN--ESDECSVEEIRVATGIEEGELKRTLQSL 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	133/499 (27%)
		CULLIN	520..655	CDD:214545	43/140 (31%)
		Cullin_Nedd8	779..846	CDD:214883
cul4a	NP_957321.1	Cullin	50..635	CDD:279260	133/499 (27%)
cul4a	NP_957321.1	CULLIN	427..567	CDD:214545	43/142 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920