Protein Alignment Cul5 and Cul1

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_001102097.1
• Gene: Cul1 / 362356
• RGDID: 1308157
• Length: 776
• Species: Rattus norvegicus
• Alignment Length: 657
• Identity: 206/657 - (31%)
• Similarity: 350/657 - (53%)
• Gaps: 56/657 - (8%)

  Fly   213 VRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAED------ 271
            :..|.|.:|...:|..:..::..:.:|::..||||:..:.:|:.||.:|||.|..|.:|
  Rat   159 IYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGP 223

  Fly   272 KLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILT 336
            .|.:|:|:||..:|..|..||..:|.|..|:|.|..|||.|:::|.||:.|.:.||..|:...|.
  Rat   224 TLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELA 288

  Fly   337 YTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLAD 401
            .....|||..||.....|...|:...:.|.|..|:.|:.|:..|:|....:  |:.||.:.|||.
  Rat   289 RKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKL--LETHIHNQGLAA 351

  Fly   402 MLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTS 466
            :....|....|.:.||:.:|::..|::.||.:|||:|..|:.|.|.|....:|:.:|.||
  Rat   352 IEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKM----- 411

  Fly   467 IANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYH 531
                    ....||.|||||.|||.||:::  ||.....:::..|..|::|.||:.:||||.:::
  Rat   412 --------AQSSSKSPELLARYCDSLLKKS--SKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFY 466

  Fly   532 KVHLTRRLILGTSADSEKEEDIVEWLREV-GMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHD 595
            ...|.:||:...||..:.|..::..|::. |.  :|.::|.||||||.||:|||.||:..::..:
  Rat   467 AKMLAKRLVHQNSASDDAEASMISKLKQACGF--EYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE 529

  Fly   596 AI----NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFV 656
            .:    :|::|::|:|. ..:..:.:||.|||........||..:||||||.|.:.:|.|.:. .
  Rat   530 PLDLDFSIQVLSSGSWP-FQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELV-T 592

  Fly   657 NNF-GRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILL 720
            |.| .||.|..:|||||:|..:|  ..|..:.:.|..:|::....|.:.|..|     :|.::|:
  Rat   593 NCFKNRYTLQASTFQMAILLQYN--TEDAYTVQQLTDSTQIKMDILAQVLQIL-----LKSKLLV 650

  Fly   721 MEPA-AISSPKDFAENTM--FYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQED--NQSIV 780
            :|.. |.....:...:|:  .|:         |...::.::|:  .:.:.||:.|:::  :::|.
  Rat   651 LEDENANVDEVELKPDTLIKLYL---------GYKNKKLRVNI--NVPMKTEQKQEQETTHKNIE 704

  Fly   781 QLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDI 845
            :.|.|..|.||::|||:||.:.:..|.||::..|.:.|.|...:||:.::.|||.:|:.|.|.:.
  Rat   705 EDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEK 769

  Fly   846 NMFIYVA 852
            :.:.|:|
  Rat   770 DTYSYLA 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	174/545 (32%)
		Cullin_Nedd8	779..846	CDD:214883	25/66 (38%)
Cul1	NP_001102097.1	Cullin	21..660	CDD:459983	172/528 (33%)
		Cullin_Nedd8	706..768	CDD:463146	24/61 (39%)