Protein Alignment Cul5 and Cul4a

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_001120773.1
• Gene: Cul4a / 361181
• RGDID: 1563853
• Length: 759
• Species: Rattus norvegicus
• Alignment Length: 646
• Identity: 173/646 - (26%)
• Similarity: 310/646 - (47%)
• Gaps: 72/646 - (11%)

  Fly   218 LDSWNKHIFHD--IKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENF 280
            |:.:..||..|  ::.:..:..:.::..||:|:|.|..|:    .|.:::.|:    |::|:::|
  Rat   175 LELFRNHIISDRMVQSKTIDGILLLIGRERSGEAVDRSLL----RSLLSMLSD----LQVYKDSF 231

  Fly   281 EMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIV 345
            |:.:|:.|...|..:.....|:..|..|:.:...:|.||..|...||:.|:...|...:...|:.
  Rat   232 ELKFLEETNCLYAAEGQRLMQDREVPEYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLG 296

  Fly   346 DHLNSIIAE-CPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEVI 409
            :||.:|:.: ...|:.:.....|..|::|..||..  |...::.....:|.:.|      .:.||
  Rat   297 EHLTAILQKGLEQLLDENRVPDLTQMYQLFSRVKG--GQHALLQHWSEYIKTFG------TTIVI 353

  Fly   410 TQDSEK-YVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVK 473
            ..:.:| .|:.||:..:|...:|...|..:.||:.....:|:|.:|..
  Rat   354 NPEKDKDMVQDLLDFKDKVDHVVEVCFQRNERFINLMKESFETFINKR----------------- 401

  Fly   474 YTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRR 538
                .:|..||:|.:.|..||..  :|..|.|:::..|..::::.::::.||||..::|..|.:|
  Rat   402 ----PNKPAELIAKHVDSKLRAG--NKEATDEELERILDKIMILFRFIHGKDVFEAFYKKDLAKR 460

  Fly   539 LILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHDA-----I 597
            |::|.||..:.|:.::..|: |.|  |.:.::|..||:|:::|:|:...|:..:....|     :
  Rat   461 LLVGKSASVDAEKSMLSKLKHECG--AAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSAPGPIDL 523

  Fly   598 NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRY 662
            .:.||..|.|...:. :.|.||.|:.......:.||..|||||||||...:.:..:......|:.
  Rat   524 TVNILTMGYWPTYTP-MEVHLPPEMVRLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKADFKEGKK 587

  Fly   663 DLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILLMEPAAIS 727
            :..|:.||..||..:|  :.|..|:|.:::||.:.|.||||||.||...   |.::|:..|..
  Rat   588 EFQVSLFQTLVLLMFN--EGDGFSFEEIKMATGIEDSELRRTLQSLACG---KARVLIKSPKG-- 645

  Fly   728 SPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQL-STERSQQEDNQSIVQLRILRTQEAI 791
              |:..:...|..|.:|.     ....|.|:|   ::|: .|...|....:.:.|.|..:...||
  Rat   646 --KEVEDGDKFIFNADFK-----HKLFRIKIN---QIQMKETVEEQVSTTERVFQDRQYQIDAAI 700

  Fly   792 IKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMFIYVA 852
            ::|||:||.:.:..|..||.:.||....|..  :|:::|.||:..||.||.|..|.:.|||
  Rat   701 VRIMKMRKTLGHNLLVSELYNQLKFPVKPGD--LKKRIESLIDRDYMERDKDSPNQYHYVA 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	138/534 (26%)
		CULLIN	520..655	CDD:214545	43/140 (31%)
		Cullin_Nedd8	779..846	CDD:214883	24/66 (36%)
Cul4a	NP_001120773.1	Cullin	63..660	CDD:395716	138/535 (26%)
		Cullin_Nedd8	688..753	CDD:214883	24/66 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820