Protein Alignment Cul5 and cul3a

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_955985.2
• Gene: cul3a / 324655
• ZFINID: ZDB-GENE-030131-3376
• Length: 774
• Species: Danio rerio
• Alignment Length: 673
• Identity: 170/673 - (25%)
• Similarity: 320/673 - (47%)
• Gaps: 95/673 - (14%)

  Fly   225 IFHD-------IKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENFEM 282
            ||.|       |:..|:::.:.::..||.|:..|..   .:|.:...|.....:...:|.|:||:
Zfish   152 IFRDQVVRYGCIRDHLRQTLLDMIARERRGEVVDRG---AIRNACQMLMVLGLEGRSVYEEDFEI 213

  Fly   283 AYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIVDH 347
            .:|..:.||::::|.:...||....|:|..::::.||..|....|:.|:...:...:...||..|
Zfish   214 PFLDMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKH 278

  Fly   348 LNSII----AECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEV 408
            :.:|:    :....::::.:||.|..|::|..||.:  |::.|...:..::...|.|       :
Zfish   279 MKTIVEMENSGLVHMLKNGKTEDLACMYKLFGRVPN--GLKTMCECMSWYLREQGKA-------L 334

  Fly   409 ITQDSE-----KYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIA 468
            ::::.|     .|::.||:|.::|...::.:||:|..|.       :|:..|...| :.|
Zfish   335 VSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFK-------QTIAGDFEYF-LNL----- 386

  Fly   469 NRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKV 533
                     .|:.||.|:.:.|..|::.  .|.||.:::::.|...:::.:::..||||.||:|.
Zfish   387 ---------NSRSPEYLSLFIDDKLKKG--VKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQ 440

  Fly   534 HLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHDA- 596
            ||.|||:...|...:.|::::..|: |.|  ..:.::|..||:|:.:|.....:||..:.....
Zfish   441 HLARRLLTNKSVSDDSEKNMISKLKTECG--CQFTSKLEGMFRDMSISNTTMDEFRHHLQTSQVS 503

  Fly   597 -----INIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSN------ 650
                 :.:::|..|.|...|.....::|............||..|||||:|...|||.:
Zfish   504 LCGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEVFRRFYLAKHSGRQLTLQHHMGSADLNAT 568

  Fly   651 ----------------GTITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDP 699
                            |.:...:|..::.|.|:||||.:|..:|.|  :|.::|.::..|::|:.
Zfish   569 FYGPIKKEDGSDVGVGGALLTGSNTRKHILQVSTFQMTILMLFNNR--EKFTFEEIQQETDIPER 631

  Fly   700 ELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRL 764
            ||.|.|.|| |..|..:::|..||.:    |:.....:|.:|.:|.     ....|.|:..:...
Zfish   632 ELVRALQSL-ACGKPTQRVLTKEPKS----KEIESGHVFTVNDQFT-----SKLHRVKIQTVAAK 686

  Fly   765 QLSTERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQL 829
            |..::..::|..|.:...|....:.||::|||.||:|.:..|..|:...|:..||||..:||:::
Zfish   687 QGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRI 751

  Fly   830 EWLIENKYMRRDDDDINMFIYVA 852
            |.|||.:|:.|..:|..::.|||
Zfish   752 EGLIEREYLARTPEDRKVYTYVA 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	136/563 (24%)
		Cullin_Nedd8	779..846	CDD:214883	25/66 (38%)
cul3a	NP_955985.2	Cullin	40..671	CDD:459983	136/563 (24%)
		Cullin_Nedd8	704..766	CDD:463146	24/61 (39%)