Protein Alignment Cul5 and cul1a

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_955953.2
• Gene: cul1a / 323883
• ZFINID: ZDB-GENE-030131-2603
• Length: 777
• Species: Danio rerio
• Alignment Length: 655
• Identity: 209/655 - (31%)
• Similarity: 352/655 - (53%)
• Gaps: 52/655 - (7%)

  Fly   213 VRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAED------ 271
            :..|.|.:|.:.:|..:..::..:.:|::..||||:..:.:|:.||.:|||.|..|.:|
Zfish   160 IYSLALVTWRECLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGP 224

  Fly   272 KLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILT 336
            .|.:|:|.||..:|..|..||..:|.|..|:|.|..|||.|:::|.||:.|.:.||..|:...|.
Zfish   225 TLSVYKEYFETQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELA 289

  Fly   337 YTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLAD 401
            .....|||..||.....|...|:...:.|.|..|:.|:.|:..|:|....:  |:.||.:.|||.
Zfish   290 RKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRITDGLGELKKL--LETHIYNQGLAA 352

  Fly   402 MLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTS 466
            :....|....|.:.||:.:|::..|::.||.:|||:|..|:.|.|.|....:|:.:|.||
Zfish   353 IEKCGESALNDPKMYVQTILDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKM----- 412

  Fly   467 IANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYH 531
                    ....||.|||||.|||.||:::  ||.....:::..|..|::|.||:.:||||.:::
Zfish   413 --------VQSSSKSPELLARYCDSLLKKS--SKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFY 467

  Fly   532 KVHLTRRLILGTSADSEKEEDIVEWLREV-GMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHD 595
            ...|.:||:...||..:.|..::..|::. |.  :|.::|.||||||.||:|||.||:..::..:
Zfish   468 AKMLAKRLVHQNSASDDAEASMISKLKQACGF--EYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE 530

  Fly   596 AI----NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFV 656
            .:    :|::|::|:|. ..:..:.:||.|||........||..:||||||.|.:|:|.|.:. .
Zfish   531 PLDLDFSIQVLSSGSWP-FQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYHLSKGELV-T 593

  Fly   657 NNF-GRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILL 720
            |.| .||.|..:|||||:|..:|  ..|..:.:.|..:|::....|.:.|..|     :|.::|:
Zfish   594 NCFKNRYTLQASTFQMAILLQYN--TEDVYTVQQLTDSTQIKIDILVQVLQIL-----LKSKLLV 651

  Fly   721 MEPA-AISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQED--NQSIVQL 782
            :|.. |.....:|..:|:..:   |...||.|.    ::|:  .:.:.||:.|:::  :::|.:.
Zfish   652 LEDENANVDEVEFKPDTLIKL---FLGYKNKKL----RVNI--NVPMKTEQKQEQETTHKNIEED 707

  Fly   783 RILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINM 847
            |.|..|.||::|||:||.:.:..|..|:::.|.:.|.|...:||:.::.|||.:|:.|.|.:.:.
Zfish   708 RKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDT 772

  Fly   848 FIYVA 852
            :.|:|
Zfish   773 YSYLA 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	175/543 (32%)
		Cullin_Nedd8	779..846	CDD:214883	24/66 (36%)
cul1a	NP_955953.2	Cullin	21..661	CDD:459983	173/528 (33%)
		Cullin_Nedd8	707..769	CDD:463146	23/61 (38%)