Protein Alignment Cul5 and Cul4b

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_001100421.1
• Gene: Cul4b / 302502
• RGDID: 1564494
• Length: 971
• Species: Rattus norvegicus
• Alignment Length: 918
• Identity: 216/918 - (23%)
• Similarity: 379/918 - (41%)
• Gaps: 243/918 - (26%)

  Fly   117 QVKPSSSGSSSSAS------VSASGAST-----SAAAAAAATSCSG-----------QAGKSGAS 159
            ::..|||.|||::|      .|.|.:||     .:|:.:.::.|.|           |.......
  Rat   115 KLNSSSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFED 179

  Fly   160 TSAAAGASTSAAAAAASTSASTSSAAA-------------------AAAASGSGSSSSSTSTSKK 205
            |....|..|..|..::|:|:|:|..||                   |:....:|.:.|||:.|..
  Rat   180 TLEFVGFDTKMAEESSSSSSSSSPTAATSQQQQQQLKNKSILISSVASVHHANGLAKSSTTVSSF 244

  Fly   206 NPTEDSPVRKLM----------------------------------------------------- 217
            ..::....:||:
  Rat   245 ANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYK 309

  Fly   218 ----------------------------LDS----------WNKH-----------IFHDIKHRL 233
                                        |||          |..|           :|.|..:.|
  Rat   310 ISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVL 374

  Fly   234 QESAMK------------------------------IVHAERNGDAYDAQLVVGVRESYVNLSSN 268
            |.|.:.                              ::..||||:|.|..|:    .|.:|:.|:
  Rat   375 QNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLL----RSLLNMLSD 435

  Fly   269 AEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFS 333
                |:||:::||..:|:.|...|..:..:..||..|..|:.:.:.:|.||..|...||:.::..
  Rat   436 ----LQIYQDSFEQRFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQK 496

  Fly   334 ILTYTLVNVLIVDHLNSIIAE-CPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSA 397
            .|..::...|:.:||.:|:.: ..:|:.:...:.|:|:::|..||..||.|  ::.....:|.:.
  Rat   497 SLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQV--LLQHWIEYIKAF 559

  Fly   398 GLADMLSASEVITQDSEK-YVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKM 461
            |      ::.||..:.:| .|:.||:..:|...::...|..:.:|:.|...||:|.:|..
  Rat   560 G------STIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKR----- 613

  Fly   462 ELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDV 526
                            .:|..||:|.|.|..||..  :|..|.|:::..|..::::.:::..|||
  Rat   614 ----------------PNKPAELIAKYVDSKLRAG--NKEATDEELEKMLDKIMIIFRFIYGKDV 660

  Fly   527 FMRYHKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFRTS 590
            |..::|..|.:||::|.||..:.|:.::..|: |.|  |.:.::|..||:|:::|:|:..||:..
  Rat   661 FEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECG--AAFTSKLEGMFKDMELSKDIMIQFKQY 723

  Fly   591 ISRHDA-----INIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSN 650
            :...:.     :.:.||..|.|..... :.|.||.|:.......:.||..|||||||||...:.:
  Rat   724 MQNQNVPGNIELTVNILTMGYWPTYVP-MEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGH 787

  Fly   651 GTITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIK 715
            ..:......|:.:|.|:.||..||..:|  :.::.|.|.::.||.:.|.||||||.||...   |
  Rat   788 CVLKAEFKEGKKELQVSLFQTLVLLMFN--EGEEFSLEEIKQATGIEDGELRRTLQSLACG---K 847

  Fly   716 KQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQL-STERSQQEDNQSI 779
            .::|...|..    ||..:...|..|.:|.     ....|.|:|   ::|: .|...|....:.:
  Rat   848 ARVLAKNPKG----KDIEDGDKFICNDDFK-----HKLFRIKIN---QIQMKETVEEQASTTERV 900

  Fly   780 VQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDD 844
            .|.|..:...||::|||:||.:::..|..|:.:.||....|:.  :|:::|.||:..||.||.::
  Rat   901 FQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPAD--LKKRIESLIDRDYMERDKEN 963

  Fly   845 INMFIYVA 852
            .|.:.|:|
  Rat   964 PNQYNYIA 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	184/806 (23%)
		CULLIN	520..655	CDD:214545	43/140 (31%)
		Cullin_Nedd8	779..846	CDD:214883	22/66 (33%)
Cul4b	NP_001100421.1	Cullin	276..871	CDD:279260	151/645 (23%)
		CULLIN	654..794	CDD:214545	43/142 (30%)
		Cullin_Nedd8	900..965	CDD:214883	22/66 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750