DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cul5 and Cul3

DIOPT Version :9

Sequence 1:NP_651665.2 Gene:Cul5 / 43434 FlyBaseID:FBgn0039632 Length:852 Species:Drosophila melanogaster
Sequence 2:NP_001100393.2 Gene:Cul3 / 301555 RGDID:1308190 Length:768 Species:Rattus norvegicus


Alignment Length:673 Identity:174/673 - (25%)
Similarity:322/673 - (47%) Gaps:95/673 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   225 IFHD-------IKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENFEM 282
            ||.|       |:..|:::.:.::..||.|:..|..   .:|.:...|.....:...:|.|:||.
  Rat   146 IFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRG---AIRNACQMLMILGLEGRSVYEEDFEA 207

  Fly   283 AYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIVDH 347
            .:|:.:.||::::|.:...||....|:|..::::.||..|....|:.|:...:...:...||..|
  Rat   208 PFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKH 272

  Fly   348 LNSII----AECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEV 408
            :.:|:    :....::::.:||.|..|::|..||.:  |::.|...:..::...|.|       :
  Rat   273 MKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPN--GLKTMCECMSSYLREQGKA-------L 328

  Fly   409 ITQDSE-----KYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIA 468
            ::::.|     .|::.||:|.::|...::.:||:|..|.       :|:..|...| :.|     
  Rat   329 VSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFK-------QTIAGDFEYF-LNL----- 380

  Fly   469 NRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKV 533
                     .|:.||.|:.:.|..|::.  .|.||.::::..|...:::.:::..||||.||:|.
  Rat   381 ---------NSRSPEYLSLFIDDKLKKG--VKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQ 434

  Fly   534 HLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFR-----TSIS 592
            ||.|||:...|...:.|::::..|: |.|  ..:.::|..||:|:.:|.....:||     |.:|
  Rat   435 HLARRLLTNKSVSDDSEKNMISKLKTECG--CQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVS 497

  Fly   593 RHDA-INIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTI--T 654
            .... :.:::|..|.|...|.....::|............||..|||||:|...|||.:..:  |
  Rat   498 LGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNAT 562

  Fly   655 FV--------------------NNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDP 699
            |.                    :|..::.|.|:||||.:|..:|.|  :|.::|.::..|::|:.
  Rat   563 FYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNR--EKYTFEEIQQETDIPER 625

  Fly   700 ELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRL 764
            ||.|.|.|| |..|..:::|..||.:    |:.....:|.:|.:|.     ....|.|:..:...
  Rat   626 ELVRALQSL-ACGKPTQRVLTKEPKS----KEIESGHIFTVNDQFT-----SKLHRVKIQTVAAK 680

  Fly   765 QLSTERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQL 829
            |..::..::|..|.:...|....:.||::|||.||:|.:..|..|:...||..||||..:||:::
  Rat   681 QGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRI 745

  Fly   830 EWLIENKYMRRDDDDINMFIYVA 852
            |.|||.:|:.|..:|..::.|||
  Rat   746 EGLIEREYLARTPEDRKVYTYVA 768

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul5NP_651665.2 Cullin 33..743 CDD:279260 139/562 (25%)
CULLIN 520..655 CDD:214545 42/143 (29%)
Cullin_Nedd8 779..846 CDD:214883 26/66 (39%)
Cul3NP_001100393.2 Interaction with KLHL18. /evidence=ECO:0000250|UniProtKB:Q13618 2..41
Cullin 34..665 CDD:395716 139/563 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 677..698 3/20 (15%)
Cullin_Nedd8 698..759 CDD:402267 25/60 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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