DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul5 and Cul3

DIOPT Version :9

Sequence 1:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_057925.1	Gene:	Cul3 / 26554	MGIID:	1347360	Length:	768	Species:	Mus musculus

Alignment Length:	673	Identity:	174/673 - (25%)
Similarity:	322/673 - (47%)	Gaps:	95/673 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 IFHD-------IKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLEIYRENFEM 282
            ||.|       |:..|:::.:.::..||.|:..|..   .:|.:...|.....:...:|.|:||.
Mouse   146 IFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRG---AIRNACQMLMILGLEGRSVYEEDFEA 207

  Fly   283 AYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIVDH 347
            .:|:.:.||::::|.:...||....|:|..::::.||..|....|:.|:...:...:...||..|
Mouse   208 PFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKH 272

  Fly   348 LNSII----AECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEV 408
            :.:|:    :....::::.:||.|..|::|..||.:  |::.|...:..::...|.|       :
Mouse   273 MKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPN--GLKTMCECMSCYLREQGKA-------L 328

  Fly   409 ITQDSE-----KYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIA 468
            ::::.|     .|::.||:|.::|...::.:||:|..|.       :|:..|...| :.|
Mouse   329 VSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFK-------QTIAGDFEYF-LNL----- 380

  Fly   469 NRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKV 533
                     .|:.||.|:.:.|..|::.  .|.||.::::..|...:::.:::..||||.||:|.
Mouse   381 ---------NSRSPEYLSLFIDDKLKKG--VKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQ 434

  Fly   534 HLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFR-----TSIS 592
            ||.|||:...|...:.|::::..|: |.|  ..:.::|..||:|:.:|.....:||     |.:|
Mouse   435 HLARRLLTNKSVSDDSEKNMISKLKTECG--CQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVS 497

  Fly   593 RHDA-INIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTI--T 654
            .... :.:::|..|.|...|.....::|............||..|||||:|...|||.:..:  |
Mouse   498 LGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNAT 562

  Fly   655 FV--------------------NNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDP 699
            |.                    :|..::.|.|:||||.:|..:|.|  :|.::|.::..|::|:.
Mouse   563 FYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNR--EKYTFEEIQQETDIPER 625

  Fly   700 ELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRL 764
            ||.|.|.|| |..|..:::|..||.:    |:.....:|.:|.:|.     ....|.|:..:...
Mouse   626 ELVRALQSL-ACGKPTQRVLTKEPKS----KEIESGHIFTVNDQFT-----SKLHRVKIQTVAAK 680

  Fly   765 QLSTERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQL 829
            |..::..::|..|.:...|....:.||::|||.||:|.:..|..|:...||..||||..:||:::
Mouse   681 QGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRI 745

  Fly   830 EWLIENKYMRRDDDDINMFIYVA 852
            |.|||.:|:.|..:|..::.|||
Mouse   746 EGLIEREYLARTPEDRKVYTYVA 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	139/562 (25%)
		CULLIN	520..655	CDD:214545	42/143 (29%)
		Cullin_Nedd8	779..846	CDD:214883	26/66 (39%)
Cul3	NP_057925.1	Interaction with KLHL18. /evidence=ECO:0000250\|UniProtKB:Q13618	2..41
		Cullin	35..664	CDD:279260	139/562 (25%)
		CULLIN	421..563	CDD:214545	42/143 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..698		3/20 (15%)
		Cullin_Nedd8	700..760	CDD:287520	24/59 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810