Protein Alignment Cul5 and cul-5

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_505616.2
• Gene: cul-5 / 179413
• WormBaseID: WBGene00000840
• Length: 765
• Species: Caenorhabditis elegans
• Alignment Length: 857
• Identity: 383/857 - (44%)
• Similarity: 541/857 - (63%)
• Gaps: 111/857 - (12%)

  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCLWDEKGAAKIYDCLQQDIVEFIVQAQSQ 77
            |:|.|.....||..||.|.:|:...|||||:.|:.:..|.:.|..||.|.|.:.|.:::.:|..:
 Worm     3 FDEEWSKADPIVHALLHQKSVTPAAWQDLFYHVYKITSWVDDGPLKIRDILTRCINDYVHEANKR 67

  Fly    78 VQAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSASVSASGASTSAAA 142
            :::.:.:.:||..||.||.:|:.|:|.|||||:::::|
 Worm    68 IRSLQTDGSLLIGYIKEWNRFYQQANILPLPFKKIDES--------------------------- 105

  Fly   143 AAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTSTSKKNP 207
                                                                        |::..
 Worm   106 ------------------------------------------------------------SRRRS 110

  Fly   208 TEDSP---VRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNA 269
            ..::|   :|.:||:.||:.||.:|..:|...|:::|..||:|:..|||.|:|:|||:|.|:..|
 Worm   111 VPETPEESIRTVMLEKWNEIIFMNISEQLLVEALRLVKEERDGNIIDAQNVIGIRESFVALNDRA 175

  Fly   270 -EDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLE---PS 330
             ||.|.:||::||..:::.|.|:|:........|.|||.||.|||.||.||:.|||||||   |:
 Worm   176 GEDPLLVYRQSFERQFIEQTTEYYKKICGNLLNELGVLEYMVYADKKLEEEQQRAKRYLEMNSPT 240

  Fly   331 SFSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIM 395
            |...:...:: .|:....::|:|||..||...:.|||..::||:.|...  |::.::..:..||.
 Worm   241 SGKHMEKAVI-ALVESFEDTILAECSKLIASKDVERLQRLYRLIRRTRS--GIDTVLKCIDTHIR 302

  Fly   396 SAGLADMLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFK 460
            :.||.||.:.:|.::.|.|:||::||.:|:|||.|||..|.||.|.|||||.||:.||||:|:||
 Worm   303 TEGLNDMRNNAENLSTDPERYVQQLLLMFDKFSSLVREGFCDDARLLTARDKAFRAVVNDSSIFK 367

  Fly   461 MELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKD 525
                |.:.|:..:..:.||||.||||||||:|||:|.|||:||||:||.:|..||||||||.|||
 Worm   368 ----TEMMNKKGRTLSVESKCAELLANYCDLLLRKTQLSKKLTSEEIDEKLNQVLLVLKYVENKD 428

  Fly   526 VFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTS 590
            ||||:|:.||:|||||..|||.||||.:|..|||.|||:|.||:|:||.|||::::|:|:.|:.:
 Worm   429 VFMRFHRAHLSRRLILEMSADQEKEEMMVTKLRECGMPSDAVNKLSRMLQDIELNKDMNSSFKKA 493

  Fly   591 I-------SRHDAINIKILNAGAWAR-CSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHH 647
            :       |..|:||:|:||.|||.| .|||:..|||.||||::|::|.||||:|:||||.|.||
 Worm   494 LTGTNNNKSIADSINMKVLNGGAWGRGGSERIRFSLPRELEDFVPEMEAFYKKQHNGRKLCWMHH 558

  Fly   648 MSNGTITF-VNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAF 711
            .|:||:.| ..|.||:||:.|||||||||.:|.|.|||||.|.|||||||||.||.|||.||||:
 Worm   559 WSSGTMVFGTANGGRFDLECTTFQMAVLFCFNDRAHDKISLETLRLATELPDAELNRTLLSLVAY 623

  Fly   712 PKIKKQILLME-PAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQED 775
            ||::.||||.: |:...:.:||.::|.|.||.:|.:|||||||:|||:|||||||||.|.:.:::
 Worm   624 PKMRYQILLCDVPSTTVTARDFTDSTKFLINHDFNVVKNGKSQQRGKVNLIGRLQLSLEANAEKE 688

  Fly   776 NQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRR 840
            ::|||.||.||.||.|:||:|.||....|.|..||::|||.:|:|::|:||||::||||||||.|
 Worm   689 HESIVALRELRVQEGIVKILKTRKTYTLAQLTMELVEILKPLFIPNRKIIKEQIDWLIENKYMER 753

  Fly   841 DDDDINMFIYVA 852
            ..||||.|:|::
 Worm   754 RADDINTFVYIS 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	310/726 (43%)
		CULLIN	520..655	CDD:214545	81/142 (57%)
		Cullin_Nedd8	779..846	CDD:214883	39/66 (59%)
cul-5	NP_505616.2	Cullin	18..656	CDD:279260	312/731 (43%)
		CULLIN	423..562	CDD:214545	79/138 (57%)
		Cullin_Nedd8	692..759	CDD:214883	39/66 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163388
Domainoid	1	1.000	596	1.000	Domainoid score	I98
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2597
Inparanoid	1	1.050	731	1.000	Inparanoid score	I314
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49236
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0005530
OrthoInspector	1	1.000	-	-		oto18362
orthoMCL	1	0.900	-	-		OOG6_107737
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2468
SonicParanoid	1	1.000	-	-		X3952
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800