DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul5 and cul-3

DIOPT Version :9

Sequence 1:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_503151.1	Gene:	cul-3 / 178547	WormBaseID:	WBGene00000838	Length:	777	Species:	Caenorhabditis elegans

Alignment Length:	697	Identity:	182/697 - (26%)
Similarity:	335/697 - (48%)	Gaps:	111/697 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 PVRKLMLDSWNKHIF--HDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAEDKLE 274
            ||..|.||::...|.  :.|..|::::.::::..:|..:..:..   |::.:...|.|...|...
Worm   136 PVYNLGLDAYRTEILRQNGIGDRIRDALLELIKLDRKSNQINWH---GIKNACDMLISLGIDSRT 197

  Fly   275 IYRENFEMAYLKATVEFYR------LKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFS 333
            :|.:.||...||.|.::||      |..     :|....|:...:..:.:|..||.|||:..:.:
Worm   198 VYEDEFERPLLKETSDYYRDVCKNWLSG-----DNDACFYLAQVEIAMHDEASRASRYLDKMTEA 257

  Fly   334 ILTYTLVNVLIVDHLNSII----AECPALIRDYETERLNLMFRLMDRV-----MHGVGVEPMMGD 389
            .:...:.:|::.:|:.:|:    .....::...:.|.|..:||:..|:     :.|.|::.::..
Worm   258 KILQVMDDVMVAEHIQTIVYMQNGGVKFMLEHKKIEDLTRIFRIFKRIGDSVTVPGGGLKALLKA 322

  Fly   390 LQRHIMSAGLADMLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVN 454
            :..::...|  ..:..:|.:.::...:|..||:|.:.||.|:..||.||..|.......|:|.:|
Worm   323 VSEYLNETG--SNIVKNEDLLKNPVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLN 385

  Fly   455 DTSVFKMELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLK 519
                         :||         :.||.:|.|.|.:||..  .|.::..::|.:|.:|:::.:
Worm   386 -------------SNR---------QSPEFVALYMDDMLRSG--LKCVSDAEMDNKLDNVMILFR 426

  Fly   520 YVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDL 583
            |:..||||.:|.|.:|.:||:|..|...:.|:.::..|: |.|  ..:..:|..||:|.::...|
Worm   427 YLQEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTECG--CQFTQKLENMFRDKELWLTL 489

  Fly   584 NTQFR-------TSISRHDAINIKILNAGAW--ARCSERVSVSLPIELEDYIPDVEEFYKKKHSG 639
            .|.||       |.:|..  |::::|.||.|  .:|:   .|.||.||........::|.:||:|
Worm   490 ATSFRDWREAQPTKMSID--ISLRVLTAGVWPTVQCN---PVVLPQELSVAYEMFTQYYTEKHTG 549

  Fly   640 RKLQWYHHMSNGTI--TFV-----------NNFGRYD--------------LDVTTFQMAVLFAW 677
            |||.....:.|..:  ||.           |..|...              |.|.|.||.:|..:
Worm   550 RKLTINTLLGNADVKATFYPPPKASMSNEENGPGPSSSGESMKERKPEHKILQVNTHQMIILLQF 614

  Fly   678 NQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQ 742
            |  .|::||.:.|....::|:.||:|.|.|| |..|..::||:.:    :..||..:     ::.
Worm   615 N--HHNRISCQQLMDELKIPERELKRNLQSL-ALGKASQRILVRK----NKGKDAID-----MSD 667

  Fly   743 EFAIVKNGKSQ-RRGKLNLI-GRLQLSTERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAA 805
            |||:..|.:|: .|.|:.:: |:::  :|...:|..|.:...|.|..:.||::|||.||::|:..
Worm   668 EFAVNDNFQSKLTRVKVQMVTGKVE--SEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNN 730

  Fly   806 LQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMFIYVA 852
            |..|:...|::.|:||..:||:::|.|||.:|:.||:.|...:.|:|
Worm   731 LVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	143/584 (24%)
		CULLIN	520..655	CDD:214545	45/146 (31%)
		Cullin_Nedd8	779..846	CDD:214883	26/66 (39%)
cul-3	NP_503151.1	Cullin	32..674	CDD:279260	146/590 (25%)
		CULLIN	427..567	CDD:214545	45/146 (31%)
		Cullin_Nedd8	709..769	CDD:287520	24/59 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820