Protein Alignment Cul5 and cul-6

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_502412.1
• Gene: cul-6 / 178214
• WormBaseID: WBGene00000841
• Length: 729
• Species: Caenorhabditis elegans
• Alignment Length: 871
• Identity: 203/871 - (23%)
• Similarity: 374/871 - (42%)
• Gaps: 177/871 - (20%)

  Fly    14 EEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCLW----------DEKGAAKIYDCLQQDIV 68
            |.||...:..:..|.|::.:|::.:..|:..|:.:|..          .|..:..:|..|:..|.
 Worm     4 EAVWGTLQDGLNLLYRREHMSKKYYMMLYDAVYNICTTTTLANSNNNSPEFASEFLYKQLENYIR 68

  Fly    69 EFIVQAQSQVQAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSASVSA 133
            .:::..:.::.|..|:: ||....:||..|...:......|:.|.::
 Worm    69 TYVIAIRDRISACSGDE-LLGKCTIEWDNFKFSTRICNCIFQYLNRN------------------ 114

  Fly   134 SGASTSAAAAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSS 198
                                                                             
 Worm   115 ----------------------------------------------------------------- 114

  Fly   199 STSTSKKNPTEDS-----PVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGV 258
              ..|||  .||.     .:.||.||.|....|.:.|.:..::.::::..||.|...::..:..|
 Worm   115 --FVSKK--VEDKNGEIVEIYKLALDIWKAEFFDNFKVKTIDAILELILLERCGSTINSTHISSV 175

  Fly   259 RESYVNLSSNAEDKLEIYRENFEMAYLKATVEFYR---LKSAEQQQENGVLAYMKYADSKLREEE 320
            .|...        :|:||:.:||..:|.||..||:   |.|.|.     |:.||...:::|.:||
 Worm   176 VECLT--------ELDIYKVSFEPQFLDATKLFYKQEVLNSKET-----VIEYMITVENRLFQEE 227

  Fly   321 VRAKRYLEPSSFSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEP 385
            .|::|||.||:..:|..:..::||.|.|..:.:|...|:...:.|.|..|:.|..||.|  |:|.
 Worm   228 YRSRRYLGPSTNDLLIDSCESILISDRLKFLHSEFERLLEARKDEHLTRMYSLCRRVTH--GLED 290

  Fly   386 MMGDLQRHIMSAG--LADMLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIA 448
            :...|::.|:..|  ....|:....:....::|:.:|||:...:.:|:..||:.:..|:.:.|.|
 Worm   291 LRVYLEKRILKEGHETLQRLAKDSGLKTTPKEYITKLLEVHEIYFNLINKAFDRNALFMQSLDKA 355

  Fly   449 FKTVVNDTSVFKMELPTSIANRGVKYTAPE----SKCPELLANYCDMLLRRTPLSKRLTSEQIDA 509
            .|..:...:|..:              |||    ::..:.||.|||.||      |:.:..|.:.
 Worm   356 SKDFIEANAVTML--------------APEKHRSTRSADYLARYCDQLL------KKNSKVQDET 400

  Fly   510 RLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREV-GMPADYVNRLARM 573
            .|...|.||||::.||||..|::...:.|:|..:||..:.||..:..|... |:  :|...|.:|
 Worm   401 ALDKALTVLKYISEKDVFQLYYQNWFSERIINNSSASDDAEEKFITNLTATEGL--EYTRNLVKM 463

  Fly   574 FQDIKVSEDLNTQFRTSISRHDAI--NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKK 636
            .:|.|:|:||.|:|: .|....:|  |:.:...|||... :::.:.||.||...:.:.:.||...
 Worm   464 VEDAKISKDLTTEFK-DIKTEKSIDFNVILQTTGAWPSL-DQIKIILPRELSTILKEFDTFYNAS 526

  Fly   637 HSGRKLQWYHHMSNGTITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPEL 701
            |:||:|.|.:....|.:.......:|...||..|:..|:.:|::  |..:.|.:..|.|:.....
 Worm   527 HNGRRLNWAYSQCRGEVNSKAFEKKYVFIVTASQLCTLYLFNEQ--DSFTIEQISKAIEMTAKST 589

  Fly   702 RRTLWSLVAFPKIKKQILLMEPAAI---SSPKD-FAENTMFYINQEFAIVKNGKSQRRGKLNLIG 762
            ...:.||..         :::|..:   .:.|| :..:.:..:|.::|       .::.:::|..
 Worm   590 SAIVGSLNP---------VIDPVLVVDKGNEKDGYPPDAVVSLNTKYA-------NKKVRVDLTT 638

  Fly   763 RLQLSTERSQQEDNQSIVQL-RILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIK 826
            .::.:|...:.:..|:.|:. |....:..|::|||.||.:.:..|..|:|..||:.|.|:.:|||
 Worm   639 AIKKATADRETDAVQNTVESDRKYEIKACIVRIMKTRKSLTHTLLINEIISQLKSRFTPNVQMIK 703

  Fly   827 EQLEWLIENKYMRRDDDDINMFIYVA 852
            ..:|.|||..|:||.:::.|::.|:|
 Worm   704 ICIEILIEQLYIRRSENEHNVYEYLA 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	166/740 (22%)
		CULLIN	520..655	CDD:214545	42/137 (31%)
		Cullin_Nedd8	779..846	CDD:214883	25/67 (37%)
cul-6	NP_502412.1	Cullin	10..596	CDD:279260	162/714 (23%)
		CULLIN	411..547	CDD:214545	42/139 (30%)
		Cullin_Nedd8	656..723	CDD:214883	25/66 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820