Protein Alignment Cul5 and cul-2

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_001023008.1
• Gene: cul-2 / 176806
• WormBaseID: WBGene00000837
• Length: 791
• Species: Caenorhabditis elegans
• Alignment Length: 892
• Identity: 200/892 - (22%)
• Similarity: 363/892 - (40%)
• Gaps: 180/892 - (20%)

  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCL-----WDEKGAAKIYDCLQ-------Q 65
            |::||...|..::.::....::..:|...|..|:.:|:     ..|:...::..|:|       |
 Worm    28 FDKVWVQLRPSIIDIINLRPITNVQWHHKFSDVYDICVSIPTPLSERLYNEVKACIQEHVRQKRQ 92

  Fly    66 DIVEFIVQAQSQVQAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSAS 130
            |||:.            ....||..|...||.|...:.::...|
 Worm    93 DIVDV------------DPDLLLQEYHKMWRVFHEGAIFIHRLF--------------------- 124

  Fly   131 VSASGASTSAAAAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGS 195
                                |...|..............|..||............
 Worm   125 --------------------GYLNKQFVKQKRCTDLDNFAQYAAFLQIPDVKEIGC--------- 160

  Fly   196 SSSSTSTSKKNPTEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGD-AYDAQLVVGVR 259
                                |.|:.|.:.:...|..:|.:..:..:..:|.|: .:.|..|.||.
 Worm   161 --------------------LALEIWKEDLVKTILPQLVKLLLIAIDNDRKGNFPHIANEVSGVI 205

  Fly   260 ESYVNLSSN--------------AEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMK 310
            .|:|.:...              .|.....|:|:||...|..|.::|...:.:...:.....||:
 Worm   206 NSFVKMEETDFDVVPAEGARYKARESTTAFYQESFEKPLLTDTEQYYSALAQKMLTDLSCSEYME 270

  Fly   311 YADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMD 375
            .....|.:||:|||:||..||...:......|:|..|.:.:.|.|..||.:.|.:.|..|:||:.
 Worm   271 QVIVLLEQEEMRAKKYLHESSVEKVITLCQKVMIKAHKDKLHAVCHDLITNEENKDLRNMYRLLK 335

  Fly   376 RVMHGVGVEPMMGDLQRHIMSAGL--ADMLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDD 438
            .:..|:.|  |:.:.:.::...||  ...|:...|    .:::||.:|.::|||:|:....|.||
 Worm   336 PIQAGLSV--MVKEFEEYVKKKGLEAVSRLTGENV----PQQFVENVLRVYNKFNDMKTAVFMDD 394

  Fly   439 PRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLT 503
            ..|.:..|.|.:.|||     ..|...|:           .|..|.||.|.|.||:::  :|.|:
 Worm   395 GEFSSGLDKALQGVVN-----SKEPGQSV-----------PKASERLARYTDGLLKKS--TKGLS 441

  Fly   504 SEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVN 568
            ...::|:|...:::.:|:.:||:|.:::...|..|||..||...:.||.::..|:: ....::.:
 Worm   442 ETDLEAKLDSAIVIFRYIEDKDIFQKFYSKMLANRLIASTSISMDAEELMINKLKQ-ACGYEFTS 505

  Fly   569 RLARMFQDIKVSEDLNTQFRTSISRHDAI--NIK-------ILNAGAWARCSERVSVS------- 617
            :|:|||.||.:|::|:..|...|:....:  ::|       ||.||:|...:.::|.:
 Worm   506 KLSRMFTDIGLSQELSNNFDKHIADIKTVQPDVKFVPTQTMILQAGSWPLNAPQLSTNSNNQTAQ 570

  Fly   618 ------LPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRYDLDVTTFQMAVLFA 676
                  ||..|:..|.:.|:||..||:||||.|..:||.|.:.......:|...:..:|||.|..
 Worm   571 DVANFHLPRILQPVIQEFEKFYTGKHNGRKLTWLFNMSQGDVRLTYLDKQYVAQMYVYQMAALLC 635

  Fly   677 WNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYIN 741
            :.:|  |.|..:::.....:....|.:|:.:::       .:.|:    ....::...:::..:|
 Worm   636 FERR--DAILVKDIGEEIGVSGDYLLKTIRTIL-------DVTLL----TCDDQNLTADSLVRLN 687

  Fly   742 QEFAIVKNGKSQRRGKLNL-IGRLQLSTERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAA 805
            ...       :.:|.|..| ..::..:.|:.|:....::.|.|....:.||::|||.||.:.:.|
 Worm   688 MSM-------TSKRMKFRLQAPQVNKAVEKEQEAVANTVSQDRKYYMECAIVRIMKTRKVLKHNA 745

  Fly   806 LQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMFIYVA 852
            |..|::|..|..|.|....||:.:|.|||..|::|.|.: :.:.|:|
 Worm   746 LVTEIMDQTKGRFSPDVPFIKKSIEDLIEKMYIQRTDQN-DEYQYLA 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	166/777 (21%)
		Cullin_Nedd8	779..846	CDD:214883	25/66 (38%)
cul-2	NP_001023008.1	Cullin	32..662	CDD:459983	163/738 (22%)
		Cullin_Nedd8	722..784	CDD:463146	24/61 (39%)