Protein Alignment Cul5 and cul-1

DIOPT Version :10

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_499309.1
• Gene: cul-1 / 176466
• WormBaseID: WBGene00000836
• Length: 780
• Species: Caenorhabditis elegans
• Alignment Length: 664
• Identity: 181/664 - (27%)
• Similarity: 335/664 - (50%)
• Gaps: 62/664 - (9%)

  Fly   213 VRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNL---------SSN 268
            |..|.|..|.:::|:|:|.::.::.::::.:||.|...:::.:.||.|..|.|         ..:
 Worm   155 VYTLALVVWKRNLFNDLKDKVIDAMLELIRSERTGSMINSRYISGVVECLVELGVDDSETDAKKD 219

  Fly   269 AE-DKLEIYRENFEMAYLKATVEFYRLKSAEQQQENG-VLAYMKYADSKLREEEVRAKRYLEPSS 331
            || .||.:|:|.||:.:|:||..||..::|......| |..||...:::|.:|:.|.:.||..|:
 Worm   220 AETKKLAVYKEFFEVKFLEATRGFYTQEAANFLSNGGNVTDYMIKVETRLNQEDDRCQLYLNSST 284

  Fly   332 FSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMS 396
            .:.|.....:|||.:.|:.:......|:.|...:.|:.||:|.|||.:  |::.:...|:.||..
 Worm   285 KTPLATCCESVLISNQLDFLQRHFGGLLVDKRDDDLSRMFKLCDRVPN--GLDELRKSLENHIAK 347

  Fly   397 AGLADMLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKM 461
            .|...:...:.....|::.||:.|||:..::..||..:|.::|.|:.:.|.|..:.:|:.:|.|.
 Worm   348 EGHQALERVAMEAATDAKLYVKTLLEVHERYQSLVNRSFKNEPGFMQSLDKAATSFINNNAVTKR 412

  Fly   462 ELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDV 526
            ..|          .|..:|..||||.|||.|||::  ||.....:::.....:::|.||:::|||
 Worm   413 APP----------QAQLTKSAELLARYCDQLLRKS--SKMPDEAELEELQTKIMVVFKYIDDKDV 465

  Fly   527 FMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSI 591
            |.:::....::|||...||..|.|.:.:..|:.: ...:|..||::|..|.:||:||...|:.
 Worm   466 FSKFYTKMFSKRLISELSASDEAEANFITKLKSM-CGYEYTARLSKMVNDTQVSKDLTADFKE-- 527

  Fly   592 SRHDAI-------NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMS 649
            .:.|.:       |:.:|::|:|. ......::||.:|...|....:||.:|.:||:|.|.:..|
 Worm   528 KKADMLGQKSVEFNVLVLSSGSWP-TFPTTPITLPQQLSKTIEIFGQFYNEKFNGRRLTWVYSQS 591

  Fly   650 NGTITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLV----- 709
            .|.||......:|....||.||..:..:|::  |..:.|.:..||::.:......:.||:
 Worm   592 RGEITSTAFPKKYVFTATTAQMCTMLLFNEQ--DSYTVEQIAAATKMDEKSAPAIVGSLIKNLVL 654

  Fly   710 -AFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQ 773
             |..:::|:..:...|.:|..|       .|:|::..:..:..:.::..:    |...:.:::.:
 Worm   655 KADTELQKEDEVPMTATVSLNK-------AYMNKKVRVDLSKFTMKQDAV----RDTENVQKNVE 708

  Fly   774 EDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYM 838
            ||.:|::       ...|::|||.|||:.:..|..|:|..|...|.|..:|||..:..|||.:||
 Worm   709 EDRKSVI-------SACIVRIMKTRKRVQHQQLMTEVITQLSGRFKPKVEMIKRCIGSLIEKEYM 766

  Fly   839 RRDDDDINMFIYVA 852
            .|.:...:::.|:|
 Worm   767 LRTEGQKDLYEYLA 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	153/554 (28%)
		Cullin_Nedd8	779..846	CDD:214883	22/66 (33%)
cul-1	NP_499309.1	Cullin	17..678	CDD:459983	151/549 (28%)
		Cullin_Nedd8	710..772	CDD:463146	24/68 (35%)