Protein Alignment Cul5 and cul2

DIOPT Version :9

• Sequence 1: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: XP_002935209.2
• Gene: cul2 / 100492608
• XenbaseID: XB-GENE-960931
• Length: 766
• Species: Xenopus tropicalis
• Alignment Length: 875
• Identity: 229/875 - (26%)
• Similarity: 391/875 - (44%)
• Gaps: 153/875 - (17%)

  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCL-WDEKGAAKIYDCLQQDIVEFIVQAQS 76
            |:|.|......:..::..|.|.:..|.|.|..::.:|: :.|....::|...:..:...:.|..:
 Frog    10 FDETWNKLLTTIKAVVMLDYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVQQLHT 74

  Fly    77 QVQAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSASVSASGASTSAA 141
            :| ....|| :|..|...|.::...::|:...:|.|                        :|...
 Frog    75 RV-LDSAEQ-VLVMYYRYWEEYSRGADYMDCLYRYL------------------------NTQYI 113

  Fly   142 AAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTSTSKKN 206
            .....|....|.|..|...:                                            .
 Frog   114 KKNKLTEADLQYGYGGVDMN--------------------------------------------E 134

  Fly   207 PTEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSS-NAE 270
            |..:  :.:|.||.|.|.:...::..|....:|.:..:|.|:..:.:::.||..|:|::.. ..:
 Frog   135 PLME--IGELALDLWRKLMIEPLQDTLLRMLLKEIKRDRCGEDPNQKVIHGVINSFVHVEQYKKK 197

  Fly   271 DKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSIL 335
            ..|:.|:|.||:.:|..|.|:|:.:::...||:....||:....:|::||:|.::||.|||::.:
 Frog   198 FPLKFYQEIFELPFLAETGEYYKQEASNLLQESNCSQYMEKILGRLKDEEIRCRKYLHPSSYNKV 262

  Fly   336 TYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLA 400
            .:.....::.|||..:.|||..:||......:..|:.|:..|.:  |:..|:.:||.||...||.
 Frog   263 IHECQQRMVADHLQFLHAECHNIIRQERRSDMANMYTLLRAVSN--GLPHMIQELQNHIHDEGLR 325

  Fly   401 DM--LSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMEL 463
            .:  ||...:.||    :||.:||:.:||..||.:..|.|..|::|.|.|...|||
 Frog   326 AISNLSQENMPTQ----FVESVLEVHSKFVQLVNSVLNGDQHFMSALDKALTCVVN--------- 377

  Fly   464 PTSIANRGVKYTAPESKC--PELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDV 526
                      |..|:|.|  |||||.|||.:|:::  :|.:|..:::.:|...:.|.||:::|||
 Frog   378 ----------YREPKSVCKAPELLAKYCDNMLKKS--AKGMTENEVEDKLTSFITVFKYIDDKDV 430

  Fly   527 FMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSI 591
            |.:::...|.:|||.|.|...:.||.::..|:: ....::.::|.||:.|:.||.|||.:|...|
 Frog   431 FQKFYARMLAKRLIHGLSMSMDSEETMINKLKQ-ACGYEFTSKLHRMYTDMSVSADLNNKFNNFI 494

  Fly   592 SRHDAI-------NIKILNAGAWARCSERVSV-SLPIELEDYIPDVEEFYKKKHSGRKLQWYHHM 648
            ...|.:       .|.:|.||||.......|. ::|.|||..:...|.||.:..|||||.|.|::
 Frog   495 KNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYNQHFSGRKLTWLHYL 559

  Fly   649 SNGTITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPK 713
            ..|.:........|...|||:|||||.|:|  ..:.::|:.|:.:|::.:.||.:|:.||:....
 Frog   560 CTGEVKMNYLCKPYVAMVTTYQMAVLLAFN--NSEIVTYKELQDSTQMNEKELTKTIKSLLDVKM 622

  Fly   714 IKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQ----- 773
            |...         |..:|....:.|.:|..|       |.:|.|..:...:|..|.:..|
 Frog   623 INHD---------SDKEDIDGESTFSLNMNF-------SSKRTKFKITTPMQKDTPQGAQPTCAE 671

  Fly   774 ---------------EDNQSIV-QLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSK 822
                           |..:|.| :.|.:..|.||::|||.||.:.:.||..|:|...:..|.||.
 Frog   672 EAMLWRGERRFSLEVEQTRSAVDEDRKMYLQAAIVRIMKARKILRHNALIQEVISQSRARFNPSI 736

  Fly   823 KMIKEQLEWLIENKYMRRDDDDINMFIYVA 852
            .|||:.:|.||:.:|:.|.....:.:.|||
 Frog   737 SMIKKCIEVLIDKQYIERSQASADEYSYVA 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	188/723 (26%)
		CULLIN	520..655	CDD:214545	48/142 (34%)
		Cullin_Nedd8	779..846	CDD:214883	25/67 (37%)
cul2	XP_002935209.2	Cullin	14..644	CDD:395716	190/740 (26%)
		Cullin_Nedd8	696..756	CDD:402267	24/59 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010