DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul5 and cul5b

DIOPT Version :9

Sequence 1:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	XP_009293667.1	Gene:	cul5b / 100006147	ZFINID:	ZDB-GENE-091113-45	Length:	807	Species:	Danio rerio

Alignment Length:	879	Identity:	507/879 - (57%)
Similarity:	627/879 - (71%)	Gaps:	125/879 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCLWDEKGAAKIYDCLQQDIVEFIVQAQS- 76
            ||:.|...|.||||||||::|::::|.|||..||.|||||:||.|||:..|::||::||.|||:
Zfish    15 FEDKWDLMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILDFIKQAQAM 79

  Fly    77 -----------QVQAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSAS 130
                       :|.:.:.:.|||..|||||||||||.:.||.||.:||
Zfish    80 ENIIVFLSLCVRVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFSKLE----------------- 127

  Fly   131 VSASGASTSAAAAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGS 195
                            .:..|..|
Zfish   128 ----------------ITLLGNQG----------------------------------------- 135

  Fly   196 SSSSTSTSKKNPTEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRE 260
                  ::||:..|||.|||||||:||:.||.:||.|||:||||:|||||.|:|:|:|||:||||
Zfish   136 ------SNKKSNVEDSIVRKLMLDTWNESIFCNIKSRLQDSAMKLVHAERLGEAFDSQLVIGVRE 194

  Fly   261 SYVNLSSNAEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKR 325
            |||||.||.:|||:|||||||.:||.:|..||:.::....|:|||..||||||.||||||.||.|
Zfish   195 SYVNLCSNTDDKLQIYRENFEKSYLDSTERFYKTQAPSYLQQNGVQNYMKYADGKLREEEKRALR 259

  Fly   326 YLEP----SSFSILTYTLVNVLIVDHLNSIIAECPALIRDYETE---------------RLNLMF 371
            |||.    :|...|....||.|:.....:|:.|||.:|:..|||               .|:|||
Zfish   260 YLETRRECNSVQALMECCVNALVTSFKETILTECPGMIKRNETESEYGRSSGTKGSASSELHLMF 324

  Fly   372 RLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEVITQDSEKYVERLLELFNKFSDLVRNAFN 436
            .|||:|..  |:|||:.||:.||||||||||::::|.||.|||||||:||.|||:||.||:.||.
Zfish   325 SLMDKVPS--GIEPMLKDLEDHIMSAGLADMVASAETITTDSEKYVEQLLTLFNRFSKLVKEAFQ 387

  Fly   437 DDPRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVKY-TAPESKCPELLANYCDMLLRRTPLSK 500
            |||||||:||.|:|.||||.::||:|||  :..:||.. |.||||||||||||||||||:|||||
Zfish   388 DDPRFLTSRDKAYKAVVNDATIFKLELP--LKQKGVSLKTQPESKCPELLANYCDMLLRKTPLSK 450

  Fly   501 RLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPAD 565
            :||||:|:|:|::||||||||.||||||||||.||||||||..|||||.||::||||||||||||
Zfish   451 KLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPAD 515

  Fly   566 YVNRLARMFQDIKVSEDLNTQFRTSISRH-------DAINIKILNAGAWARCSERVSVSLPIELE 623
            |||:|||||||||||||||..|: .:.:|       |::||||||||||:|.||:|.||||.|||
Zfish   516 YVNKLARMFQDIKVSEDLNQSFK-EMHKHNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELE 579

  Fly   624 DYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYE 688
            |.||:||:||||.||||||.|:|.||||.|||.|..|:|||:|||||:|||||||||..::||:|
Zfish   580 DLIPEVEDFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPRERISFE 644

  Fly   689 NLRLATELPDPELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQ 753
            ||:|||||||.||||||||||||||:|:|:|..|| .:.|||||||.|:|.|||||:::||.|.|
Zfish   645 NLKLATELPDAELRRTLWSLVAFPKLKRQVLSYEP-VVGSPKDFAEGTVFSINQEFSLIKNSKVQ 708

  Fly   754 RRGKLNLIGRLQLSTERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMF 818
            :|||:||||||||:|||.::|:|:.||||||||||||||:|||:|||::||.||.||::||||||
Zfish   709 KRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKRISNAQLQTELVEILKNMF 773

  Fly   819 LPSKKMIKEQLEWLIENKYMRRDDDDINMFIYVA 852
            ||.|||||||:|||||:||::||:.|||.|||:|
Zfish   774 LPQKKMIKEQIEWLIEHKYIKRDETDINTFIYMA 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	415/748 (55%)
		CULLIN	520..655	CDD:214545	103/141 (73%)
		Cullin_Nedd8	779..846	CDD:214883	51/66 (77%)
cul5b	XP_009293667.1	Cullin	20..698	CDD:279260	424/763 (56%)
		CULLIN	470..613	CDD:214545	105/143 (73%)
		Cullin_Nedd8	740..799	CDD:287520	44/58 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594192
Domainoid	1	1.000	843	1.000	Domainoid score	I61
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2597
Inparanoid	1	1.050	1010	1.000	Inparanoid score	I280
OMA	1	1.010	-	-		QHG49236
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0005530
OrthoInspector	1	1.000	-	-		otm25970
orthoMCL	1	0.900	-	-		OOG6_107737
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770