Protein Alignment Sirt7 and Sirt1

DIOPT Version :9

• Sequence 1: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_062786.1
• Gene: Sirt1 / 93759
• MGIID: 2135607
• Length: 737
• Species: Mus musculus
• Alignment Length: 450
• Identity: 97/450 - (21%)
• Similarity: 162/450 - (36%)
• Gaps: 138/450 - (30%)

  Fly    87 KRKERVEIYKERVVEREDAPHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWT 151
            |||:|.:|                ..:|....::.:.|.::..||||:|.:..|||:|...||:.
Mouse   225 KRKKRKDI----------------NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYA 273

  Fly   152 LL----------QKGQDI-------------------GEHDLSSANPTYTH--MALYELHRRRLL 185
            .|          |...||                   |:.     .|:..|  :||.:...:.|.
Mouse   274 RLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQF-----QPSLCHKFIALSDKEGKLLR 333

  Fly   186 HHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNCRPNSVYWRQFDTTEMTARYCHKTHRLCH 250
            ::  :||.|.|...:|:.|  :.:.||:.....|..|:      .:.|...:.....::....|.
Mouse   334 NY--TQNIDTLEQVAGIQR--ILQCHGSFATASCLICK------YKVDCEAVRGDIFNQVVPRCP 388

  Fly   251 RC--SEPL---YDTIVHFGERGNVKWPLNWAGATANAQRADVILCLGSSLKVLKKYTWLWQMDRP 310
            ||  .|||   ...||.|||  |:....:.| ...:....|:::.:||||||           ||
Mouse   389 RCPADEPLAIMKPEIVFFGE--NLPEQFHRA-MKYDKDEVDLLIVIGSSLKV-----------RP 439

  Fly   311 AR-------QRAKICVVNLQWTPKDAIASIKINGKCDQVMAQLMHLLHIPVPVYTK--------- 359
            ..       ......::|.:..| .....:::.|.||.::.:|.|.|.   ..|.|
Mouse   440 VALIPSSIPHEVPQILINREPLP-HLHFDVELLGDCDVIINELCHRLG---GEYAKLCCNPVKLS 500

  Fly   360 ---EKDP----IFAHASLLMPEELHTLTQPLLKNADEEEAFTTTTEETQDS----TISSESCSFN 413
               ||.|    ...|.|.|.|..||.          .|::.:......|||    |:..::.:.|
Mouse   501 EITEKPPRPQKELVHLSELPPTPLHI----------SEDSSSPERTVPQDSSVIATLVDQATNNN 555

  Fly   414 YSDLPIGKGPRIRTPIKNGRRVKTNLELRQKFKTLNGQDEEIKVEH--VKTNGEVKTEKD 471
            .:||.:.:...:.   :..:.|:|:..:           |.|.||:  .|..|....:|:
Mouse   556 VNDLEVSESSCVE---EKPQEVQTSRNV-----------ENINVENPDFKAVGSSTADKN 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	57/256 (22%)
Sirt1	NP_062786.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56
		Interaction with H1-4. /evidence=ECO:0000250|UniProtKB:Q96EB6	2..268		16/58 (28%)
		Interaction with CLOCK. /evidence=ECO:0000269|PubMed:18662547	2..131
		Nuclear localization signal	32..39
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..125
		Interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:Q96EB6	135..533		81/366 (22%)
		Nuclear export signal	138..145
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..171
		Nuclear localization signal	223..230		3/4 (75%)
		SIRT1	246..481	CDD:238699	60/264 (23%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000250|UniProtKB:Q96EB6	248..251		0/2 (0%)
		Nuclear export signal	425..431		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	514..539		7/34 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..713

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810