Protein Alignment Sirt7 and HST3

DIOPT Version :10

• Sequence 1: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_014668.1
• Gene: HST3 / 854190
• SGDID: S000005551
• Length: 447
• Species: Saccharomyces cerevisiae
• Alignment Length: 468
• Identity: 106/468 - (22%)
• Similarity: 172/468 - (36%)
• Gaps: 155/468 - (33%)

  Fly   100 VEREDAPHVI--EAKVEQLANI---ISQAKHLVCYTGAGISTAALIPDYRGSQGIWTLLQK---- 155
            ::.|...|:|  :|..|.|..:   :|:::.:.|.||||||..|.|||:|.|.|::.|::|
Yeast    24 LQTEKLAHIIGLDADDEVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDCSQ 88

  Fly   156 ------GQDIGE---------------------HDLSSANPTYTHMALYELHRRRLLHHVVSQNC 193
                  |:::.:                     .::..|.||.||..:..|..|..|....:||.
Yeast    89 YWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNI 153

  Fly   194 DGLHLRSG-------LPRNSLS---------EIHGNMYVEVCKNC---RPNSVYWRQFDTTEMTA 239
            |||....|       ||..|.|         ::||::....|..|   .|.|.||.:
Yeast   154 DGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSR-------- 210

  Fly   240 RYCHKTHR--LCHRCSEPLYDTIVHFGERGNVKWPLNWAGATANAQRADVILCLGSSLKVLKKYT 302
              |.:...  ||..| |.|.:..::.|:|                       .|||::.:|:...
Yeast   211 --CLRRGELPLCPDC-EALINKRLNEGKR-----------------------TLGSNVGILRPNI 249

  Fly   303 WLWQMDRPARQRAKICVVNLQWTPKDAI-----------ASIKINGKCDQVMAQLMHLLH----I 352
            .|:..:.|:      |.:..|....|.|           .|:|::| ..|::.:|...:|    :
Yeast   250 VLYGENHPS------CEIITQGLNLDIIKGNPDFLIIMGTSLKVDG-VKQLVKKLSKKIHDRGGL 307

  Fly   353 PVPVYTKEKDPIFA---HASLLMPEELHTLTQPLLKNADEEEAFTTTT----EETQDSTISSESC 410
            .:.|   .|.||..   |.  ::..::|:       :.|....|..:.    .:|||........
Yeast   308 IILV---NKTPIGESSWHG--IIDYQIHS-------DCDNWVTFLESQIPDFFKTQDQIKKLRQL 360

  Fly   411 SFNYSDL---------PIGKGPRIRTPIK--NGRRVKTNLELRQKFKTLN----------GQDEE 454
            ....|||         .||..|  .||::  .|..::.|.||..|.|:||          ...||
Yeast   361 KREASDLRKQMKAQKDSIGTPP--TTPLRTAQGIDIQGNNELNTKIKSLNTVKRKILSPENSSEE 423

  Fly   455 IKVEHVKTNGEVK 467
            .:.|::.|....|
Yeast   424 DEEENLDTRKRAK 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	63/276 (23%)
HST3	NP_014668.1	SIR2-fam	53..332	CDD:238698	73/331 (22%)